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Research

Cyanophora paradoxa reveals unique repair signature" > Elevated DNA insertion rate in Cyanophora paradoxa reveals unique repair signature

  • First Published June 12, 2026
Research

Evolution of an adaptive, inducible defensive trait in a model crustacean

  • First Published June 5, 2026
Research

Genome evolution in parthenogenetic nematodes shaped by chromosome rearrangements and introgression

  • First Published May 29, 2026
Research

Transposable element small RNAs and large RNAs in aging brains and implications in Huntington's and Parkinson's disease

  • First Published May 28, 2026
Research

Whole-genome variant detection in long-read sequencing data from ultralow input patient samples

  • First Published May 28, 2026
Research

Interplay between purging and admixture shapes genetic load in an invasive guppy population

  • First Published May 20, 2026
Research

Herbaria provide a valuable resource for obtaining informative mRNA

  • First Published May 19, 2026
Research

N-ethyl-N-nitrosourea" > Evidence for negative selection against somatic mutations induced in normal fibroblasts by N-ethyl-N-nitrosourea

  • First Published May 15, 2026
Research

Characterizing cytosine methylation of polymorphic transposable element insertions using the human pangenome resources

  • First Published May 14, 2026
Research

Allele-specific splicing modulates protein isoforms and Alzheimer's disease risk

  • First Published May 14, 2026
Research

Drosophila" > Structural variants are enriched in deleterious visible phenotypes in Drosophila

  • First Published May 14, 2026
Research

Single-cell transcriptomics reveals rapid divergence of genes guiding meiosis and spermiogenesis in two passerine birds

  • First Published May 14, 2026
Research

6A reprogramming unveils vitamin-driven post-transcriptional regulation in mice" > Tissue-specific mRNA m6A reprogramming unveils vitamin-driven post-transcriptional regulation in mice

  • First Published May 11, 2026
Research

Dynamic body size evolution during speciation of predatory cichlid fishes in the Lake Malawi superradiation

  • First Published May 4, 2026
Research

Single-cell template strand sequencing reveals culture-induced chromosomal instability in a gibbon cell line

  • First Published May 4, 2026
Research

R-loops shape the H2A.Z landscape and promote balanced lineage allocation during differentiation

  • First Published May 4, 2026
Research

Age-dependent mutational loads in human tRNA genes are tumor-specific and result in chimeric tRNA sequences that could disrupt the genetic code

  • First Published April 15, 2026
Research

Drosophila innate immune response" > A genome-wide survey reveals that a diverse array of enhancers coordinates the Drosophila innate immune response

  • First Published April 15, 2026
Research

Epigenetic characterization of pseudogenes across human tissues

  • First Published April 15, 2026
Research

Dynamics and consequences of differential RNA isoform production during cardiomyocyte fate determination and early-stage maturation

  • First Published April 3, 2026
Research

Centromeric instability and chromoanasynthesis observed in nine supernumerary marker chromosomes resolved with long-read genome sequencing

  • First Published March 25, 2026
Research

ACTB methylation regulates SMARCA4 genomic occupancy to promote translation and reduce adhesion in colorectal cancer cells

  • First Published March 25, 2026
Research

Aphelenchus avenae implicates P5CS in nematode desiccation stress response" > Haplotype-resolved telomere-to-telomere genome of Aphelenchus avenae implicates P5CS in nematode desiccation stress response

  • First Published March 23, 2026
Research

cis-antisense RNA duplexes" > A transcriptome-wide systematic search does not detect A-to-I RNA editing in cis-antisense RNA duplexes

  • First Published March 12, 2026
Research

Confounding factors in assessing the enriched expression of somatic mutant alleles in bulk tumor samples

  • First Published March 4, 2026
Research

cis-regulatory modules acting during vertebrate organogenesis" > Functional genomics analysis of developing zebrafish and human endoderm reveals highly conserved cis-regulatory modules acting during vertebrate organogenesis

  • First Published March 4, 2026
Research

Dynamic A-to-I RNA editing in response to gut microbiome in honey bees

  • First Published March 4, 2026
Research

Assessing the readiness of Oxford Nanopore sequencing for clinical genomics applications

  • First Published February 11, 2026
Research

Drosophila species" > Transposable elements contribute to the evolution of host shift–related genes in cactophilic Drosophila species

  • First Published February 10, 2026
Research

Degrees of convergent evolution in rodent adaptations to arid environments

  • First Published January 21, 2026
Research

Saccharomyces cerevisiae strains" > Natural diversity of telomere length distributions across 100 Saccharomyces cerevisiae strains

  • First Published January 16, 2026
Research

Stable genome structures in living fossil fishes

  • First Published January 13, 2026
Research

Landscape of microRNA and target expression variation and covariation in single mouse embryonic stem cells

  • First Published January 12, 2026
Research

MHC in newts illuminates the evolutionary dynamics of complex regions in giant genomes

  • First Published January 12, 2026
Research

LTR7-PLAAT4 as a potential oncogene and therapeutic target in pancreatic adenocarcinoma" > Transcriptomic landscape of transposable elements reveals LTR7-PLAAT4 as a potential oncogene and therapeutic target in pancreatic adenocarcinoma

  • First Published January 8, 2026
Research

XIST isoform in male peripheral glia" > Transcription and potential functions of a novel XIST isoform in male peripheral glia

  • First Published December 12, 2025
Research

Drosophila testis tumor stem cell–like cells" > Cell-type- and chromosome-specific chromatin landscapes and DNA replication programs of Drosophila testis tumor stem cell–like cells

  • First Published December 10, 2025
Research

Genome-wide nucleosome and transcription factor responses to genetic perturbations reveal chromatin-mediated mechanisms of transcriptional regulation

  • First Published December 9, 2025
Research

Drosophila intestine" > Polycomb misregulation in enterocytes drives tissue decline in the aging Drosophila intestine

  • First Published November 17, 2025
Research

Modest increase in the de novo single-nucleotide mutation rate in house mice born by assisted reproduction

  • First Published November 13, 2025
Research

Sorex araneus" > Dynamic metabolic and molecular changes during seasonal shrinking in Sorex araneus

  • First Published November 4, 2025
Research

3C sites in poly(A) RNA" > Nanopore direct RNA sequencing reveals METTL2A-mediated m3C sites in poly(A) RNA

  • First Published October 30, 2025
Research

A gene regulatory element modulates myosin expression and controls cardiomyocyte response to stress

  • First Published October 22, 2025
Research

Epigenetic and evolutionary features of ape subterminal heterochromatin

  • First Published October 22, 2025
Research

Genomic regulatory landscape underlying the antiviral response of Atlantic salmon

  • First Published October 22, 2025
Research

Autism spectrum disorder risk genes have convergent effects on transcription and neuronal firing patterns in primary neurons

  • First Published October 20, 2025
Research

Synergistic regulation by H3K36 and H3K27 methylation defines the chromatin landscape to control virulence and secondary metabolism in a fungal pathogen

  • First Published October 14, 2025
Research

Loss of multilevel 3D genome organization during breast cancer progression

  • First Published October 9, 2025
Research

Adaptation of centromeres to breakage through local genomic and epigenomic remodeling in wheat

  • First Published September 30, 2025
Research

T2T-CHM13 improves read mapping and detection of clinically relevant genetic variation in the Swedish population

  • First Published September 16, 2025
Research

Long-read sequencing reveals HBV integration patterns and oncogenic impact on early-onset hepatocellular carcinoma

  • First Published September 16, 2025
Research

Tribolium sibling species" > Dynamic evolution of satellite DNAs drastically differentiates the genomes of Tribolium sibling species

  • First Published September 16, 2025
Research

Mapping multitissue regulatory variants reveals a liver-centric coexpression network associated with duck egg-laying performance

  • First Published September 10, 2025
Research

APOBEC3A drives deaminase mutagenesis in human gastric epithelium

  • First Published August 26, 2025
Research

Widespread specific intron retention events in nuclear RNA complexes identified by sedimentation analysis of pluripotent cellular extracts

  • First Published August 26, 2025
Research

Molecular and genetic landscapes of retina and brain microglia in neurodegenerative diseases

  • First Published August 26, 2025
Research

Intergenic accumulation of RNA polymerase II maintains the potential for swift transcriptional restart upon release from quiescence

  • First Published August 12, 2025
Research

Phylogenetic relatedness rather than aquatic habitat fosters horizontal transfer of transposable elements in animals

  • First Published August 8, 2025
Research

Xist upstream deletion leads to dysregulation of Xist and autosomal gene expression" > Xist upstream deletion leads to dysregulation of Xist and autosomal gene expression

  • First Published August 6, 2025
Research

Distinct classes of lamina-associated domains are defined by differential patterns of repressive histone methylation

  • First Published August 5, 2025
Research

H3K27 and H3K9 methylation mask potential CTCF binding sites to maintain 3D genome integrity

  • First Published August 5, 2025
Research

Epigenetic drift score captures directional methylation variability and links aging to transcriptional, metabolic, and genetic alterations

  • First Published August 1, 2025
Research

Genotype imputation from low-coverage data for medical and population genetic analyses

  • First Published July 22, 2025
Research

Transcriptional modulation unique to vulnerable motor neurons predicts ALS across species and SOD1 mutations

  • First Published July 17, 2025
Research

Drosophila melanogaster genome" > Genetic variation in recalcitrant repetitive regions of the Drosophila melanogaster genome

  • First Published July 16, 2025
Research

Alternative splicing generates HER2 isoform diversity underlying antibody–drug conjugate resistance in breast cancer

  • First Published July 15, 2025
Research

Lambdoid phages with abundant Chi recombination hotspots reflect diverse viral strategies for recombination-dependent growth

  • First Published July 10, 2025
Research

Dynamic barriers modulate cohesin positioning and genome folding at fixed occupancy

  • First Published July 8, 2025
Research

cis-regulatory elements of target genes" > Wnt signaling activation induces CTCF binding and loop formation at cis-regulatory elements of target genes

  • First Published June 23, 2025
Research

An iPSC-based model of 47,XYY Jacobs syndrome reveals a DNA methylation-independent transcriptional dysregulation shared with male X aneuploid cells

  • First Published June 10, 2025
Research

Comprehensive functional annotation of ESR1-driven enhancers in breast cancer reveals hierarchical activity independent of genomic and epigenomic contexts

  • First Published June 10, 2025
Research

Multi-species analysis of inflammatory response elements reveals ancient and lineage-specific contributions of transposable elements to NF-kB binding

  • First Published June 6, 2025
Research

Mitotic chromosomes harbor cell type– and species-specific structural features within a universal loop array conformation

  • First Published June 6, 2025
Research

Accurate genotyping of three major respiratory bacterial pathogens with ONT R10.4.1 long-read sequencing

  • First Published June 2, 2025
Research

Androgen receptor–mediated assisted loading of the glucocorticoid receptor modulates transcriptional responses in prostate cancer cells

  • First Published June 2, 2025
Research

Oxygen-induced stress reveals context-specific gene regulatory effects in human brain organoids

  • First Published June 2, 2025
Research

cis-regulatory landscape of erythroid precursors" > Regeneration alters open chromatin and cis-regulatory landscape of erythroid precursors

  • First Published June 2, 2025
Research

Genetic effects on chromatin accessibility uncover mechanisms of liver gene regulation and quantitative traits

  • First Published May 20, 2025
Research

Birth of protein-coding exons by ancient domestication of LINE-1 retrotransposon

  • First Published May 8, 2025
Research

Oryza" > Continuous infiltration and evolutionary trajectory of nuclear organelle DNA in Oryza

  • First Published April 25, 2025
Research

Extreme heterochiasmy and high rates of sex-reversed recombination result in large yet homomorphic sex chromosomes in the Emei moustache toad

  • First Published April 24, 2025
Research

Meta-analysis of activated neurons reveals dynamic regulation of diverse classes of alternative splicing

  • First Published April 24, 2025
Research

Integrating genetic variation with deep learning provides context for variants impacting transcription factor binding during embryogenesis

  • First Published April 15, 2025
Research

cis-regulatory variation modifies the penetrance of pathogenic SHROOM3 variants in craniofacial microsomia" > Common cis-regulatory variation modifies the penetrance of pathogenic SHROOM3 variants in craniofacial microsomia

  • First Published April 15, 2025
Research

Long-read genomics reveal extensive nuclear-specific evolution and allele-specific expression in a dikaryotic fungus

  • First Published April 11, 2025
Research

C. elegans" > Cohesin organizes 3D DNA contacts surrounding active enhancers in C. elegans

  • First Published April 10, 2025
Research

Lake Malawi cichlid pangenome graph reveals extensive structural variation driven by transposable elements

  • First Published April 10, 2025
Research

Diverse evolutionary trajectories of mitocoding DNA in mammalian and avian nuclear genomes

  • First Published March 31, 2025
Research

Unraveling undiagnosed rare disease cases by HiFi long-read genome sequencing

  • First Published March 26, 2025
Research

Analysis of canine gene constraint identifies new variants for orofacial clefts and stature

  • First Published March 24, 2025
Research

Optical genome mapping enables accurate testing of large repeat expansions

  • First Published March 20, 2025
Research

Expanded methylome and quantitative trait loci detection by long-read profiling of personal DNA

  • First Published March 20, 2025
Research

Unexpectedly low recombination rates and presence of hotspots in termite genomes

  • First Published March 20, 2025
Research

Heterogeneous and novel transcript expression in single cells of patient-derived clear cell renal cell carcinoma organoids

  • First Published March 19, 2025
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