Volume 36, Issue 9 | September 2026

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Research
- - The impact of sex, age, and genetic ancestry on DNA methylation across tissues
    Winona Oliveros
    Jose Miguel Ramirez
    Maria Sopena-Rios
    Pau Clavell-Revelles
    Marta Melé
    First Published July 14, 2026
  - Methylation variability and LINE-1 transcriptional activation in multiple myeloma
    Qianhui Wan
    Amy Leung
    Mahek Vinod Bhandari
    Hiroyuki Kato
    Joo Y. Song
    Dustin E. Schones
    First Published July 17, 2026
  - Long-read sequencing reveals widespread novel splicing and neojunction-derived neoantigens in nasopharyngeal carcinoma
    Yi Shuai
    Hualiang Yao
    Bo Wang
    Grace T.Y. Chung
    Xiangeng Wang
    Ming Zhong Zhongxu Zhu
    ...[+2 authors]...,
    Cheuk Shuen Li
    Chi Man Tsang
    Kwok-Wai Lo
    Xin Wang
    First Published July 8, 2026
  - Identification of genomic features that uniquely impact estrogen receptor alpha binding and its effects on gene expression in endometrial cancer
    Alexandra Richey
    Noel Kitchen
    Craig M. Rush
    Jeffery M. Vahrenkamp
    Hosiana Abewe
    Kyle S. Osbourne
    ...[+1 authors]...,
    Alex J. Bott
    Brian K. Dalley
    Jared Rutter
    Jason Gertz
    First Published July 17, 2026
  - Cross-species variant-to-function analyses implicate MEIS1 in conferring sleep abnormalities and impaired cerebellar development
    Amber J. Zimmerman
    Erika Almeraya Del Valle
    Matthew C. Pahl
    Fusun Doldur-Balli
    Brendan T. Keenan
    Patrick Z. Liu Zoe Y. Shetty Trisha R. Tsundupalli Justin Palermo Anitra Krishnan James A. Pippin Andrew D. Wells Olivia J. Veatch Alessandra Chesi
    ...[+9 authors]...,
    Philip R. Gehrman
    Alex C. Keene
    Allan I. Pack
    Struan F.A. Grant
    First Published July 30, 2026
  - Convergence and conflict among telomere-specialized transposons across 60 million years of Drosophilid evolution
    Jae Hak Son
    Matthew A. Lawlor
    Mahek Virani
    Weihuan Cao
    Mia T. Levine
    Christopher E. Ellison
    First Published July 1, 2026
Methods
- - A SNP panel for coanalysis of capture and shotgun ancient DNA data
    Romain Fournier
    Alice Pearson Fulton
    Daniel Tabin
    David Reich
    First Published August 12, 2026
  - De novo structural variants in autism spectrum disorder disrupt distal regulatory interactions of neuronal genes
    Ketrin Gjoni
    Xingjie Ren
    Amanda Everitt
    Yin Shen
    Katherine S. Pollard
    First Published July 8, 2026
  - Knowledge-driven interpretable neural networks provide mechanistic insight
    Yan Ke
    Tianwei Yu
    First Published July 24, 2026
  - Fast and memory efficient partial order alignment with minipoa
    Haodong Liu
    Pinglu Zhang
    Yanming Wei
    Qinzhong Tian
    Yixiao Zhai
    Quan Zou
    Mengting Niu
    First Published July 24, 2026
  - A sequence-based classifier distinguishes phenotype-associated genes from other gene models in plants
    Nikee Shrestha
    Zhongjie Ji
    Xiuru Dai
    Pinghua Li
    James C. Schnable
    First Published July 14, 2026
  - Pattern-Filter structural validation of single-cell RNA-seq reads reduces artifactual barcodes and improves biological resolution
    Qiang Su
    Xiaoming Zhou
    Yi Long
    Fuyu Duan
    Qizhou Lian
    First Published August 12, 2026
  - High-accuracy SNV calling for bacterial isolates using deep learning with AccuSNV
    Herui Liao
    Arolyn Conwill
    Ian Light-Maka
    Martin Fenk
    Alyssa H. Mitchell
    Evan B. Qu Paul Torrillo
    ...[+2 authors]...,
    Jacob S. Baker
    Lilly R. Bartsch
    Felix M. Key
    Tami D. Lieberman
    First Published July 6, 2026
Resources
- - Dietary effects on cytosolic and mitochondrial tRNA abundance and modification patterns across mouse tissues
    Simeiyun Liu
    Andrew D. Holmes
    Ruoxia Zhao
    Cassandra Herbert
    Patrick A. Limbach
    Todd M. Lowe
    Upasna Sharma
    First Published July 8, 2026
  - A pangenome framework uncovers the role of deletions in repeated evolution of cave-derived traits
    Emma Y. Roback
    Maggs X
    Edward S. Ricemeyer
    Adam Warlen
    Rachel A. Carroll
    Christine G. Elsik
    ...[+1 authors]...,
    Alex C. Keene
    Nicolas Rohner
    Suzanne E. McGaugh
    Wesley C. Warren
    First Published August 13, 2026
  - Uniform processing and analysis of IGVF massively parallel reporter assay data with MPRAsnakeflow
    Jonathan D. Rosen
    Arjun Devadas Vasanthakumari
    Kilian Salomon
    Nikola de Lange
    Pyaree Mohan Dash
    Pia Keukeleire Ali Hassan Alejandro Barrera Beniamin Krupkin
    ...[+4 authors]...,
    Grace Oualline
    Martin Kircher
    Michael I. Love
    Max Schubach
    First Published August 11, 2026

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Table of Contents

Volume 36, Issue 9 | September 2026

Research

The impact of sex, age, and genetic ancestry on DNA methylation across tissues

Methylation variability and LINE-1 transcriptional activation in multiple myeloma

Long-read sequencing reveals widespread novel splicing and neojunction-derived neoantigens in nasopharyngeal carcinoma

Identification of genomic features that uniquely impact estrogen receptor alpha binding and its effects on gene expression in endometrial cancer

Cross-species variant-to-function analyses implicate MEIS1 in conferring sleep abnormalities and impaired cerebellar development

Convergence and conflict among telomere-specialized transposons across 60 million years of Drosophilid evolution

Methods

A SNP panel for coanalysis of capture and shotgun ancient DNA data

De novo structural variants in autism spectrum disorder disrupt distal regulatory interactions of neuronal genes

Knowledge-driven interpretable neural networks provide mechanistic insight

Fast and memory efficient partial order alignment with minipoa

A sequence-based classifier distinguishes phenotype-associated genes from other gene models in plants

Pattern-Filter structural validation of single-cell RNA-seq reads reduces artifactual barcodes and improves biological resolution

High-accuracy SNV calling for bacterial isolates using deep learning with AccuSNV

Resources

Dietary effects on cytosolic and mitochondrial tRNA abundance and modification patterns across mouse tissues

A pangenome framework uncovers the role of deletions in repeated evolution of cave-derived traits

Uniform processing and analysis of IGVF massively parallel reporter assay data with MPRAsnakeflow

Table of Contents

Volume 36, Issue 9 | September 2026

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Research

Methods

Resources