Volume 36, Issue 5 | May 2026

Review
- - Hash functions in nucleotide sequence analysis
    Ke Chen
    Xiang Li
    Qian Shi
    Mingfu Shao
    Paul Medvedev
    First Published May 4, 2026
Research
- - Dynamics and consequences of differential RNA isoform production during cardiomyocyte fate determination and early-stage maturation
    Joanna Delimata-Raczek
    Natalia Koralewska
    Bart Krist
    Magdalena Rakoczy
    Marek Figlerowicz
    First Published April 3, 2026
  - A transcriptome-wide systematic search does not detect A-to-I RNA editing in cis-antisense RNA duplexes
    Zohar Rosenwasser
    Roni Cohen-Fultheim
    Ofir Shliefer
    Erez Y. Levanon
    Eli Eisenberg
    First Published March 12, 2026
  - R-loops shape the H2A.Z landscape and promote balanced lineage allocation during differentiation
    Chun-Hao Chao
    Thomas G. Fazzio
    First Published May 4, 2026
  - Single-cell template strand sequencing reveals culture-induced chromosomal instability in a gibbon cell line
    Alessia Daponte
    Gerardina Chirico
    Annalisa Paparella
    Annalaura Montanari
    Caterina Manzari
    Martina Macino Oliver Dionisi Dyck Francesco De Leonardis Flavia Angela Maria Maggiolini Alberto L'Abbate Francesco Montinaro Sandra Louzada
    ...[+7 authors]...,
    Mario Ventura
    Ashley D. Sanders
    Francesca Antonacci
    Claudia Rita Catacchio
    First Published May 4, 2026
  - Dynamic body size evolution during speciation of predatory cichlid fishes in the Lake Malawi superradiation
    Liandong Yang
    Holly Scott
    Benjamin P. Ngatunga
    Asilatu H. Shechonge
    George F. Turner
    First Published May 4, 2026
  - A genome-wide survey reveals that a diverse array of enhancers coordinates the Drosophila innate immune response
    Lianne B. Cohen
    Tamara Hadzic
    Caitlin Sauer
    Julia R. Gibbs
    Zeba Wunderlich
    First Published April 15, 2026
Methods
- - Genealogy-based trait association with LOCATER boosts power at loci with allelic heterogeneity
    Xinxin Wang
    Ryan Christ
    Erica Young
    Chul Joo Kang
    Indraniel Das
    Edward A. Belter Markku Laakso
    ...[+2 authors]...,
    Louis J.M. Aslett
    David Steinsaltz
    Nathan O. Stitziel
    Ira M. Hall
    First Published April 16, 2026
  - Simultaneous modeling of chromatin conformation changes from multiple single-cell interaction maps with ChromMovie
    Krzysztof H. Banecki
    Haoxi Chai
    Yijun Ruan
    Dariusz Plewczynski
    First Published April 8, 2026
  - Using CRISPR barcoding as a molecular clock to capture dynamic processes at single-cell resolution
    Yolanda Andres-Lopez
    Alice Santambrogio
    Ioannis Kafetzopoulos
    Christopher D. Todd
    Carla El Khouri-Gonzalez
    J-Elliot Gonzalez-Alvarez
    ...[+1 authors]...,
    Celia Alda-Catalinas
    Stephen J. Clark
    Wolf Reik
    Irene Hernando-Herraez
    First Published May 1, 2026
  - High-resolution genotype-free mapping of genetic variation with CRI-SPA-Map
    Sheila Lutz
    Megan Lawler
    Samuel Amidon
    Frank W. Albert
    First Published March 23, 2026
  - Restoring the potency of a neutralizing antibody via guided hypermutation with hyper-antibody editor HAE1
    Yuhong Wang
    Yuefeng Guo
    Qiuyu Lu
    Xinyi Liu
    Haoqi Xu
    Jiayi Chen Ruiqi Pi Shaopeng Yuan Ziting Yang
    ...[+4 authors]...,
    Rusen Lu
    Fei-Long Meng
    Tingting Gan
    Jiazhi Hu
    First Published March 19, 2026
  - Incorporating valuable prior knowledge to improve deep learning prediction of genetic perturbation responses
    Xiuhao Fu
    Chao Yang
    Chunyan Cui
    Aoyun Geng
    Yidi Sun
    Chao Zha Feifei Cui
    ...[+2 authors]...,
    Leyi Wei
    Quan Zou
    Xin Gao
    Zilong Zhang
    First Published March 26, 2026
  - k-mer cross-species profiling reveals taxon-specific TE expansions accompanied by KZFP co-option and functional impacts in ruminants
    Pengju Zhao
    Jiayi He
    Chen Peng
    Yuelang Zhang
    Chong Wang
    First Published March 23, 2026
Resource
- - Lignature provides a curated resource of ligand-induced transcriptomic signatures for signaling inference
    Ying Xin
    Md Amanullah
    Cheng Qian
    Chingmo Zhou
    Jiang Qian
    First Published April 8, 2026

Table of Contents

Volume 36, Issue 5 | May 2026

Review

Hash functions in nucleotide sequence analysis

Research

Dynamics and consequences of differential RNA isoform production during cardiomyocyte fate determination and early-stage maturation

A transcriptome-wide systematic search does not detect A-to-I RNA editing in cis-antisense RNA duplexes

R-loops shape the H2A.Z landscape and promote balanced lineage allocation during differentiation

Single-cell template strand sequencing reveals culture-induced chromosomal instability in a gibbon cell line

Dynamic body size evolution during speciation of predatory cichlid fishes in the Lake Malawi superradiation

A genome-wide survey reveals that a diverse array of enhancers coordinates the Drosophila innate immune response

Methods

Genealogy-based trait association with LOCATER boosts power at loci with allelic heterogeneity

Simultaneous modeling of chromatin conformation changes from multiple single-cell interaction maps with ChromMovie

Using CRISPR barcoding as a molecular clock to capture dynamic processes at single-cell resolution

High-resolution genotype-free mapping of genetic variation with CRI-SPA-Map

Restoring the potency of a neutralizing antibody via guided hypermutation with hyper-antibody editor HAE1

Incorporating valuable prior knowledge to improve deep learning prediction of genetic perturbation responses

k-mer cross-species profiling reveals taxon-specific TE expansions accompanied by KZFP co-option and functional impacts in ruminants

Resource

Lignature provides a curated resource of ligand-induced transcriptomic signatures for signaling inference

Table of Contents

Volume 36, Issue 5 | May 2026

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Review

Research

Methods

Resource