Volume 36, Issue 4 | April 2026

Research
- - Centromeric instability and chromoanasynthesis observed in nine supernumerary marker chromosomes resolved with long-read genome sequencing
    Kristine Bilgrav Saether
    Angelo Salazar Mantero
    Marlene Ek
    Maria Pettersson
    Elisabeth Syk Lundberg
    First Published March 25, 2026
  - Confounding factors in assessing the enriched expression of somatic mutant alleles in bulk tumor samples
    Kohei Hagiwara
    Andrew Thrasher
    Nadezhda V. Terekhanova
    Jinghui Zhang
    First Published March 4, 2026
  - ACTB methylation regulates SMARCA4 genomic occupancy to promote translation and reduce adhesion in colorectal cancer cells
    Elina Abaev-Schneiderman
    Linh Nguyen
    Raz Shalev
    Tzofit Elbaz Biton
    Anand Chopra
    Giritharan Jagadeesan Daniel Sevilla-Sanchez Nili Tickotsky Moskovitz
    ...[+3 authors]...,
    Liron Levin
    Michal Feldman
    Capucine Van Rechem
    Dan Levy
    First Published March 25, 2026
  - Functional genomics analysis of developing zebrafish and human endoderm reveals highly conserved cis-regulatory modules acting during vertebrate organogenesis
    Daniela M. Riley
    Randa Elsayed
    Mark D. Walsh
    Simaran Johal
    Ying Lin
    First Published March 4, 2026
  - Dynamic A-to-I RNA editing in response to gut microbiome in honey bees
    Yuange Duan
    Min Huang
    Lin Ye
    Ling Ma
    Yashuai Wu
    Yating Du Jiyao Liu Fan Song Li Tian
    ...[+4 authors]...,
    Wanzhi Cai
    Hu Li
    Xin Zhou
    Shiqi Luo
    First Published March 4, 2026
  - Haplotype-resolved telomere-to-telomere genome of Aphelenchus avenae implicates P5CS in nematode desiccation stress response
    Yali Zhang
    Yayi Zhou
    Yangyang Chen
    Xueyu Wang
    Boyan Hu
    Shahid Siddique Romnick A. Latina Veronica I. Casey Dexin Bo Yucheng Liao
    ...[+5 authors]...,
    Min Zhang
    Ming Sun
    Fengjuan Zhang
    Dadong Dai
    First Published March 23, 2026
Methods
- - Minimizing reference bias with an imputed personalized reference
    Kavya Vaddadi
    Mao-Jan Lin
    Sina Majidian
    Taher Mun
    Ben Langmead
    First Published March 5, 2026
  - spRefine denoises and imputes spatial transcriptomic data with a reference-free framework powered by genomic language model
    Tianyu Liu
    Tinglin Huang
    Wengong Jin
    Tinyi Chu
    Rex Ying
    First Published February 3, 2026
  - High-fidelity bidirectional translation between single-cell transcriptomes and DNA methylomes with scBOND
    Kehan Lang
    Chenyang Jia
    Siyu Li
    Yi Guo
    Dingjun Hu
    First Published March 26, 2026
  - Scalable cell-specific coexpression networks for granular regulatory pattern discovery with NeighbourNet
    Yidi Deng
    Jiadong Mao
    Jarny Choi
    Kim-Anh Lê Cao
    First Published March 5, 2026
  - Parallel analysis of replication timing, gene expression, and copy number with PARTAGE
    Lakshana Sruthi Sadu Murari
    Quinn Dickinson
    Silvia Meyer-Nava
    Juan Carlos Rivera-Mulia
    First Published March 19, 2026
  - Automated interpretable artificial intelligence genomic prediction with AIGP
    Lei Wei
    Ziqin Jiang
    Baoliang Fan
    Yidan Yan
    Zhenqiang Xu
    First Published March 5, 2026
  - Complete genetic and epigenetic architecture of D4Z4 macrosatellites in FSHD, BAMS, and reference cohorts with D4Z4End2End
    Lucinda C. Xiao
    Ayush Semwal
    Brianna St John
    Kathleen Zeglinski
    Shian Su
    James Lancaster Shifeng Xue Bruno Reversade
    ...[+3 authors]...,
    Matthew E. Ritchie
    Frédérique Magdinier
    Marnie E. Blewitt
    Quentin Gouil
    First Published March 23, 2026
Resources
- - Single-nucleus multiomic profiling of the aging mouse substantia nigra reveals conserved gene alterations linked to Parkinson's disease
    Kangli Wang
    Weikun Xia
    Yingli Gu
    Songpeng Zu
    Qian Yang
    Maria Luisa Amaral Yaozhi Wang
    ...[+2 authors]...,
    Allen Wang
    Xiang-Dong Fu
    William C. Mobley
    Bing Ren
    First Published March 4, 2026
  - A systems view on DNA damage response kinetics in Tetrahymena
    Emily Nischwitz
    Vivien A.C. Schoonenberg
    Rachel Mullner
    Albert Fradera-Sola
    Susanne Zimbelmann
    First Published January 28, 2026
  - Whole-genome sequencing of diverse 351 cultured prokaryotes including as-yet-unsequenced type strains
    Shingo Kato
    Sachiko Masuda
    Arisa Shibata
    Takashi Itoh
    Mitsuo Sakamoto
    First Published April 7, 2026
Corrigendum
- - Corrigendum: TP53-inducible putative long noncoding RNAs encode functional polypeptides that suppress cell proliferation
    Wenli Xu
    Chang Liu
    Bing Deng
    Penghui Lin
    Zhenghua Sun
    Anrui Liu Jiajia Xuan Yuying Li Keren Zhou Xiaoqin Zhang Qiaojuan Huang Hui Zhou
    ...[+7 authors]...,
    Qingyu He
    Bin Li
    Lianghu Qu
    Jianhua Yang
    First Published April 7, 2026

Table of Contents

Volume 36, Issue 4 | April 2026

Research

Centromeric instability and chromoanasynthesis observed in nine supernumerary marker chromosomes resolved with long-read genome sequencing

Confounding factors in assessing the enriched expression of somatic mutant alleles in bulk tumor samples

ACTB methylation regulates SMARCA4 genomic occupancy to promote translation and reduce adhesion in colorectal cancer cells

Functional genomics analysis of developing zebrafish and human endoderm reveals highly conserved cis-regulatory modules acting during vertebrate organogenesis

Dynamic A-to-I RNA editing in response to gut microbiome in honey bees

Haplotype-resolved telomere-to-telomere genome of Aphelenchus avenae implicates P5CS in nematode desiccation stress response

Methods

Minimizing reference bias with an imputed personalized reference

spRefine denoises and imputes spatial transcriptomic data with a reference-free framework powered by genomic language model

High-fidelity bidirectional translation between single-cell transcriptomes and DNA methylomes with scBOND

Scalable cell-specific coexpression networks for granular regulatory pattern discovery with NeighbourNet

Parallel analysis of replication timing, gene expression, and copy number with PARTAGE

Automated interpretable artificial intelligence genomic prediction with AIGP

Complete genetic and epigenetic architecture of D4Z4 macrosatellites in FSHD, BAMS, and reference cohorts with D4Z4End2End

Resources

Single-nucleus multiomic profiling of the aging mouse substantia nigra reveals conserved gene alterations linked to Parkinson's disease

A systems view on DNA damage response kinetics in Tetrahymena

Whole-genome sequencing of diverse 351 cultured prokaryotes including as-yet-unsequenced type strains

Corrigendum

Corrigendum: TP53-inducible putative long noncoding RNAs encode functional polypeptides that suppress cell proliferation

Table of Contents

Volume 36, Issue 4 | April 2026

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Research

Methods

Resources

Corrigendum