Volume 36, Issue 3 | March 2026

Review
- - A systematic guide for identifying transcription factors that directly regulate the expression of a gene of interest
    Andrew D. Bates
    Dawid Grzela
    Maciej Studzian
    Louise Brennan
    Moli Williams
    Conor Fawcett Beth Hammond
    ...[+2 authors]...,
    Manreen Grewal
    Marcin Ratajewski
    Lukasz Pulaski
    Urszula L. McClurg
    First Published February 17, 2026
Research
- - Assessing the readiness of Oxford Nanopore sequencing for clinical genomics applications
    Judith Arres
    Santosh Elavalli
    Shalini Behl
    Daniel Matias Sanchez
    Ayesha Al Ali
    Abdelrahman Ahmed Yehia Abdelaziz Saad Azza Attia Cyla Minas Sharika Pariyachery Shariq Ahmed Fatmah Aldhuhoori Nitu Thulasidharan Gurunath Katagi Omar Soliman Shilp Purohit Vinay Kusuma Raony Cardenas Thyago Cardoso Luis F. Paulin Philippe Sanio Joseph Mafofo Haiguo Wu Val Zvereff Albarah El-Khani
    ...[+19 authors]...,
    Fahed Al Marzooqi
    Tiago R. Magalhães
    Fritz J. Sedlazeck
    Javier Quilez
    First Published February 11, 2026
  - Degrees of convergent evolution in rodent adaptations to arid environments
    Domitille Chalopin
    Carine Rey
    Jeremy Ganofsky
    Juliana Blin
    Pascale Chevret
    Marion Mouginot
    ...[+1 authors]...,
    Laurent Guéguen
    Bastien Boussau
    Sophie Pantalacci
    Marie Sémon
    First Published January 21, 2026
  - Transposable elements contribute to the evolution of host shift–related genes in cactophilic Drosophila species
    Daniel Siqueira de Oliveira
    Anaïs Larue
    William Vilas Boas Nunes
    Francois Sabot
    Alejandra Bodelón
    First Published February 10, 2026
  - Pangenome analysis reveals families of ubiquitin-ligase adaptors as key genomic divergence drivers that lead to hybrid incompatibility
    Dongying Xie
    Pohao Ye
    Yiming Ma
    Zhongying Zhao
    First Published February 17, 2026
  - Natural diversity of telomere length distributions across 100 Saccharomyces cerevisiae strains
    Clotilde Garrido
    Cintia Gómez-Muñoz
    Etienne Kornobis
    Nicolas Agier
    Oana Ilioaia
    First Published January 16, 2026
Methods
- - A spectral component approach leveraging identity-by-descent graphs to address recent population structure in genomic analysis
    Ruhollah Shemirani
    Gillian M. Belbin
    Sinead Cullina
    Christa Caggiano
    Christopher R. Gignoux
    First Published December 23, 2025
  - Chromosome engineering to correct a complex rearrangement on Chromosome 8 reveals the effects of 8p syndrome on gene expression and neural differentiation
    Sophia N. Lee
    Erin C. Banda
    Lu Qiao
    Sarah L. Thompson
    Karan Singh
    First Published January 12, 2026
  - Gene duplication is associated with gene diversification and potential neofunctionalization in lung cancer evolution
    Paul Ashford
    Alexander M. Frankell
    Zofia Piszka
    Camilla S.M. Pang
    Mahnaz Abbasian
    Maise Al Bakir
    ...[+1 authors]...,
    Mariam Jamal-Hanjani
    Nicholas McGranahan
    Charles Swanton
    Christine A. Orengo
    First Published February 19, 2026
  - Read-level genotyping of short tandem repeats using long reads and single-nucleotide variation with STRkit
    David R. Lougheed
    Tomi Pastinen
    Guillaume Bourque
    First Published January 15, 2026
  - EnDeep4mC predicts DNA N4-methylcytosine sites using a dual-adaptive feature encoding framework in deep ensembles
    Shuyu Zhang
    Quan Zou
    Mengting Niu
    Zhibin Lv
    Antony Stalin
    First Published February 17, 2026
  - Mapping and quantifying nascent transcript start sites using TT-TSS-seq
    Eleanor Elgood Hunt
    Claudia Vivori
    Richard Mitter
    Vedis Agnadottir
    Folkert J. van Werven
    First Published February 17, 2026
  - Analysis of coding gene expression from small RNA sequencing
    Aygun Azadova
    Anthonia Ekperuoh
    Greg N. Brooke
    Antonio Marco
    First Published February 10, 2026
  - Early feature extraction drives model performance in high-resolution chromatin accessibility prediction
    Aayush Grover
    Till Muser
    Liine Kasak
    Lin Zhang
    Ekaterina Krymova
    First Published January 12, 2026
  - Robust and efficient annotation of cell states through gene signature scoring
    Laure Ciernik
    Agnieszka Kraft
    Florian Barkmann
    Josephine Yates
    Valentina Boeva
    First Published February 18, 2026
Resource
- - Cell type–specific gene regulatory atlas prioritizes drug targets and repurposable medicines in Alzheimer's disease
    Yunxiao Ren
    Ming Hu
    Yang E. Li
    Andrew A. Pieper
    Jeffrey Cummings
    First Published January 21, 2026
Erratum
- - Erratum: Expanded methylome and quantitative trait loci detection by long-read profiling of personal DNA
    Cristian Groza
    Bing Ge
    Warren A. Cheung
    Tomi Pastinen
    Guillaume Bourque
    First Published March 2, 2026

Table of Contents

Volume 36, Issue 3 | March 2026

Review

A systematic guide for identifying transcription factors that directly regulate the expression of a gene of interest

Research

Assessing the readiness of Oxford Nanopore sequencing for clinical genomics applications

Degrees of convergent evolution in rodent adaptations to arid environments

Transposable elements contribute to the evolution of host shift–related genes in cactophilic Drosophila species

Pangenome analysis reveals families of ubiquitin-ligase adaptors as key genomic divergence drivers that lead to hybrid incompatibility

Natural diversity of telomere length distributions across 100 Saccharomyces cerevisiae strains

Methods

A spectral component approach leveraging identity-by-descent graphs to address recent population structure in genomic analysis

Chromosome engineering to correct a complex rearrangement on Chromosome 8 reveals the effects of 8p syndrome on gene expression and neural differentiation

Gene duplication is associated with gene diversification and potential neofunctionalization in lung cancer evolution

Read-level genotyping of short tandem repeats using long reads and single-nucleotide variation with STRkit

EnDeep4mC predicts DNA N4-methylcytosine sites using a dual-adaptive feature encoding framework in deep ensembles

Mapping and quantifying nascent transcript start sites using TT-TSS-seq

Analysis of coding gene expression from small RNA sequencing

Early feature extraction drives model performance in high-resolution chromatin accessibility prediction

Robust and efficient annotation of cell states through gene signature scoring

Resource

Cell type–specific gene regulatory atlas prioritizes drug targets and repurposable medicines in Alzheimer's disease

Erratum

Erratum: Expanded methylome and quantitative trait loci detection by long-read profiling of personal DNA

Table of Contents

Volume 36, Issue 3 | March 2026

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Review

Research

Methods

Resource

Erratum