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Research

T2T-CHM13 improves read mapping and detection of clinically relevant genetic variation in the Swedish population

  • First Published September 16, 2025
Research

Long-read sequencing reveals HBV integration patterns and oncogenic impact on early-onset hepatocellular carcinoma

  • First Published September 16, 2025
Research

Tribolium sibling species" > Dynamic evolution of satellite DNAs drastically differentiates the genomes of Tribolium sibling species

  • First Published September 16, 2025
Research

Mapping multitissue regulatory variants reveals a liver-centric coexpression network associated with duck egg-laying performance

  • First Published September 10, 2025
Method

ScisTree2 enables large-scale inference of cell lineage trees and genotype calling using efficient local search

  • First Published September 3, 2025
Research

APOBEC3A drives deaminase mutagenesis in human gastric epithelium

  • First Published August 26, 2025
Resource

Quadrupia provides a comprehensive catalog of G-quadruplexes across genomes from the tree of life

  • First Published August 26, 2025
Research

Widespread specific intron retention events in nuclear RNA complexes identified by sedimentation analysis of pluripotent cellular extracts

  • First Published August 26, 2025
Research

Molecular and genetic landscapes of retina and brain microglia in neurodegenerative diseases

  • First Published August 26, 2025
Method

Robust 16S rRNA classification based on a compressed LCA index

  • First Published August 25, 2025
Resource

High-quality assembly of the Chinese white truffle genome and recalibrated divergence time estimate provide insight into the evolutionary dynamics of Tuberaceae

  • First Published August 21, 2025
Method

Estimating the size of long tandem repeat expansions from short reads with ScatTR

  • First Published August 21, 2025
Method

Tree-based differential testing using inferential uncertainty for RNA-seq

  • First Published August 21, 2025
Method

Deciphering context-specific gene programs from single-cell and spatial transcriptomics data with DeCEP

  • First Published August 21, 2025
Method

Pangenome-based genome inference using integer programming

  • First Published August 21, 2025
Method

Accurate detection of tandem repeats from error-prone sequences with EquiRep

  • First Published August 21, 2025
Method

Ultra-long sequencing for contiguous haplotype resolution of the human immunoglobulin heavy-chain locus

  • First Published August 21, 2025
Method

Efficient integration of spatial omics data for joint domain detection, matching, and alignment with stMSA

  • First Published August 14, 2025
Method

Multicondition and multimodal temporal profile inference during mouse embryonic development

  • First Published August 14, 2025
Method

Unveiling the functional fate of duplicated genes through expression profiling and structural analysis

  • First Published August 14, 2025
Method

FocalSV enables target region–based structural variant assembly and refinement using single-molecule long-read sequencing data

  • First Published August 13, 2025
Research

Intergenic accumulation of RNA polymerase II maintains the potential for swift transcriptional restart upon release from quiescence

  • First Published August 12, 2025
Research

Phylogenetic relatedness rather than aquatic habitat fosters horizontal transfer of transposable elements in animals

  • First Published August 8, 2025
Method

ERC2.0 evolutionary rate covariation update improves inference of functional interactions across large phylogenies

  • First Published August 7, 2025
Mini-Review

The paradox of R-loops: guardians of the genome or drivers of disease?

  • First Published August 6, 2025
Method

BRCA1 and BRCA2 splice isoforms" > The SeqSplice multiplexed minigene splicing assay for characterization and quantitation of variant-induced BRCA1 and BRCA2 splice isoforms

  • First Published August 6, 2025
Research

Xist upstream deletion leads to dysregulation of Xist and autosomal gene expression" > Xist upstream deletion leads to dysregulation of Xist and autosomal gene expression

  • First Published August 6, 2025
Research

Distinct classes of lamina-associated domains are defined by differential patterns of repressive histone methylation

  • First Published August 5, 2025
Resource

Interspecies systems biology links bacterial metabolic pathways to nematode gene expression, chemotaxis behavior, and survival

  • First Published August 5, 2025
Method

Genotyping of selected germline adaptive immune system loci using short-read sequencing data

  • First Published August 5, 2025
Method

3′-end ligation sequencing is a sensitive method to detect DNA nicks at potential sites of off-target activity induced by prime editors

  • First Published August 5, 2025
Research

H3K27 and H3K9 methylation mask potential CTCF binding sites to maintain 3D genome integrity

  • First Published August 5, 2025
Method

High-resolution spatial transcriptomics in fixed tissue using a cost-effective PCL-seq workflow

  • First Published August 5, 2025
Research

Epigenetic drift score captures directional methylation variability and links aging to transcriptional, metabolic, and genetic alterations

  • First Published August 1, 2025
Research

Genotype imputation from low-coverage data for medical and population genetic analyses

  • First Published July 22, 2025
Method

Aggregation of recount3 RNA-seq data improves inference of consensus and tissue-specific gene coexpression networks

  • First Published July 17, 2025
Research

Transcriptional modulation unique to vulnerable motor neurons predicts ALS across species and SOD1 mutations

  • First Published July 17, 2025
Research

Drosophila melanogaster genome" > Genetic variation in recalcitrant repetitive regions of the Drosophila melanogaster genome

  • First Published July 16, 2025
Research

Alternative splicing generates HER2 isoform diversity underlying antibody–drug conjugate resistance in breast cancer

  • First Published July 15, 2025
Method

A high-throughput screening method for selecting feature SNPs to evaluate breed diversity and infer ancestry

  • First Published July 15, 2025
Resource

Caenorhabditis elegans" > CGC1, a new reference genome for Caenorhabditis elegans

  • First Published July 15, 2025
Method

Uncovering methylation-dependent genetic effects on regulatory element function in diverse genomes

  • First Published July 14, 2025
Method

A novel multislice framework for precision 3D spatial domain reconstruction and disease pathology analysis

  • First Published July 14, 2025
Resource

A map of enhancer regions in primary human neural progenitor cells using capture STARR-seq

  • First Published July 11, 2025
Review

De novo gene birth and the conundrum of ORFan genes in bacteria

  • First Published July 10, 2025
Research

Lambdoid phages with abundant Chi recombination hotspots reflect diverse viral strategies for recombination-dependent growth

  • First Published July 10, 2025
Research

Dynamic barriers modulate cohesin positioning and genome folding at fixed occupancy

  • First Published July 8, 2025
Method

Integration of hyperspectral imaging and transcriptomics from individual cells with SpectralSeq

  • First Published July 8, 2025
Method

Batch correction methods used in single-cell RNA sequencing analyses are often poorly calibrated

  • First Published July 7, 2025
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