Method
A comparison of ancient DNA yields across ossicles and the petrous bone reveals the best preservation in the stapes and incus
- First Published June 11, 2026
Method
Reference-informed spatial domain detection using weak supervision for spatial transcriptomics
- First Published June 3, 2026
Method
Transfer learning enhances clinical utility of polygenic scores with small, phenotypically refined cohorts
- First Published June 2, 2026
Method
Augmenting transcriptome annotations through the lens of splicing evolution
- First Published May 29, 2026
Method
RECOMBINE identifies recurrent composite markers of cell types and states
- First Published May 20, 2026
Method
Cultivation-independent high-quality microbial genome reconstruction from environmental samples with midi-metagenomics
- First Published May 15, 2026
Method
Tree reconstruction guarantees from CRISPR-Cas9 lineage tracing data using Neighbor-Joining
- First Published May 14, 2026
Method
Accurate delineation of cellular niches via integrated spatial transcriptomics and histological imaging with SYMOL
- First Published May 14, 2026
Method
Using CRISPR barcoding as a molecular clock to capture dynamic processes at single-cell resolution
- First Published May 1, 2026
Method
Genealogy-based trait association with LOCATER boosts power at loci with allelic heterogeneity
- First Published April 16, 2026
Method
Balancing Gene Ontology annotation specificity in protein function prediction based on the protein sequence large graph
- First Published April 15, 2026
Method
Highly efficient and scarless genome editing via essential-gene-coupled homology-directed repair
- First Published April 15, 2026
Method
Dynamics of intronic polyadenylation in the hematopoietic lineage and its regulation by DNA methylation
- First Published April 13, 2026
Method
Simultaneous modeling of chromatin conformation changes from multiple single-cell interaction maps with ChromMovie
- First Published April 8, 2026
Method
Enabling efficient and robust analysis of tandem repeats in genomic data using Wavefront-based String Decomposer
- First Published April 8, 2026
Method
Nanopore sequencing identifies high-frequency somatic structural variations in laryngeal squamous cell carcinoma genomes
- First Published April 8, 2026
Method
Incorporating valuable prior knowledge to improve deep learning prediction of genetic perturbation responses
- First Published March 26, 2026
Method
High-fidelity bidirectional translation between single-cell transcriptomes and DNA methylomes with scBOND
- First Published March 26, 2026
Method
Complete genetic and epigenetic architecture of D4Z4 macrosatellites in FSHD, BAMS, and reference cohorts with D4Z4End2End
- First Published March 23, 2026
Method
k-mer cross-species profiling reveals taxon-specific TE expansions accompanied by KZFP co-option and functional impacts in ruminants" > k-mer cross-species profiling reveals taxon-specific TE expansions accompanied by KZFP co-option and functional impacts in ruminants
- First Published March 23, 2026
Method
High-resolution genotype-free mapping of genetic variation with CRI-SPA-Map
- First Published March 23, 2026
Method
Restoring the potency of a neutralizing antibody via guided hypermutation with hyper-antibody editor HAE1
- First Published March 19, 2026
Method
Parallel analysis of replication timing, gene expression, and copy number with PARTAGE
- First Published March 19, 2026
Method
Scalable cell-specific coexpression networks for granular regulatory pattern discovery with NeighbourNet
- First Published March 5, 2026
Method
Minimizing reference bias with an imputed personalized reference
- First Published March 5, 2026
Method
Automated interpretable artificial intelligence genomic prediction with AIGP
- First Published March 5, 2026
Method
Gene duplication is associated with gene diversification and potential neofunctionalization in lung cancer evolution
- First Published February 19, 2026
Method
Robust and efficient annotation of cell states through gene signature scoring
- First Published February 18, 2026
Method
Mapping and quantifying nascent transcript start sites using TT-TSS-seq
- First Published February 17, 2026
Method
Analysis of coding gene expression from small RNA sequencing
- First Published February 10, 2026
Method
spRefine denoises and imputes spatial transcriptomic data with a reference-free framework powered by genomic language model
- First Published February 3, 2026
Method
scSHEFT enables multiomics label transfer from scRNA-seq to scATAC-seq through dual alignment
- First Published January 20, 2026
Method
cis-regulatory elements" > A scalable computational framework for predicting gene expression from candidate cis-regulatory elements
- First Published January 16, 2026
Method
Read-level genotyping of short tandem repeats using long reads and single-nucleotide variation with STRkit
- First Published January 15, 2026
Method
Quantifying pathological progression from single-cell transcriptomic data with scPSS
- First Published January 14, 2026
Method
Strain-level metagenomic profiling using pangenome graphs with PanTax
- First Published January 14, 2026
Method
Chromosome engineering to correct a complex rearrangement on Chromosome 8 reveals the effects of 8p syndrome on gene expression and neural differentiation
- First Published January 12, 2026
Method
Early feature extraction drives model performance in high-resolution chromatin accessibility prediction
- First Published January 12, 2026
Method
A spectral component approach leveraging identity-by-descent graphs to address recent population structure in genomic analysis
- First Published December 23, 2025
Method
Automated chromatin profiling with spa-ChIP-seq uncovers the impacts of condition variations
- First Published December 12, 2025
Method
The oligogenic inheritance test GCOD detects risk genes and their interactions in congenital heart defects
- First Published December 12, 2025
Method
6A demethylation in mRNAs" > A versatile type VI CRISPR-based approach for targeted m6A demethylation in mRNAs
- First Published December 11, 2025
Method
Genome-wide maps of CPD deamination in yeast reveal the impact of DNA sequence context and nucleosome architecture on cytosine deamination rates
- First Published December 9, 2025
Method
ML-MAGES enables multivariate genetic association analyses with genes and effect size shrinkage
- First Published November 19, 2025
Method
Integration of high-throughput proteomic data and complementary omics layers with PriOmics
- First Published November 18, 2025
Method
Joint imputation and deconvolution of gene expression across spatial transcriptomics platforms
- First Published November 17, 2025
Method
OMKar automates genome karyotyping using optical maps to identify constitutional abnormalities
- First Published November 14, 2025