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Method

Genealogy-based trait association with LOCATER boosts power at loci with allelic heterogeneity

  • First Published April 16, 2026
Method

Balancing gene ontology annotation specificity in protein function prediction based on the protein sequence large graph

  • First Published April 15, 2026
Method

Highly efficient and scarless genome editing via essential gene-coupled homology-directed repair

  • First Published April 15, 2026
Research

Drosophila innate immune response" > A genome-wide survey reveals a diverse array of enhancers coordinates the Drosophila innate immune response

  • First Published April 15, 2026
Research

Epigenetic characterization of pseudogenes across human tissues

  • First Published April 15, 2026
Method

Dynamics of intronic polyadenylation in the hematopoietic lineage and its regulation by DNA methylation

  • First Published April 13, 2026
Method

Simultaneous modeling of chromatin conformation changes from multiple single-cell interaction maps with ChromMovie

  • First Published April 8, 2026
Resource

Lignature provides a curated resource of ligand induced transcriptomic signatures for signaling inference

  • First Published April 8, 2026
Method

Nanopore sequencing identifies high-frequency somatic structural variations in laryngeal squamous cell carcinoma genomes

  • First Published April 8, 2026
Method

Enabling efficient and robust analysis of tandem repeats in genomic data using wavefront-based string decomposer

  • First Published April 8, 2026
Resource

Whole-genome sequencing of diverse 351 cultured prokaryotes including as-yet-unsequenced type strains

  • First Published April 7, 2026
Corrigendum

Corrigendum: TP53-inducible putative long noncoding RNAs encode functional polypeptides that suppress cell proliferation

  • First Published April 7, 2026
Research

Dynamics and consequences of differential RNA isoform production during cardiomyocyte fate determination and early-stage maturation

  • First Published April 3, 2026
Method

Incorporating valuable prior knowledge to improve deep learning prediction of genetic perturbation responses

  • First Published March 26, 2026
Resource

Isoform- and pathway-specific regulation of post-transcriptional RNA processing in human cells

  • First Published March 26, 2026
Method

High-fidelity bidirectional translation between single-cell transcriptomes and DNA methylomes with scBOND

  • First Published March 26, 2026
Research

ACTB methylation regulates SMARCA4 genomic occupancy to promote translation and reduce adhesion in colorectal cancer cells

  • First Published March 25, 2026
Research

Centromeric instability and chromoanasynthesis observed in nine supernumerary marker chromosomes resolved with long-read genome sequencing

  • First Published March 25, 2026
Research

Aphelenchus avenae implicates P5CS in nematode desiccation stress response" > Haplotype-resolved telomere-to-telomere genome of Aphelenchus avenae implicates P5CS in nematode desiccation stress response

  • First Published March 23, 2026
Method

Complete genetic and epigenetic architecture of D4Z4 macrosatellites in FSHD, BAMS, and reference cohorts with D4Z4End2End

  • First Published March 23, 2026
Method

High-resolution genotype-free mapping of genetic variation with CRI-SPA-Map

  • First Published March 23, 2026
Method

Restoring the potency of neutralizing antibody via guided hypermutation with hyper-antibody editor

  • First Published March 19, 2026
Method

Parallel analysis of replication timing, gene expression, and copy number with PARTAGE

  • First Published March 19, 2026
Research

cis-antisense RNA duplexes" > A transcriptome-wide systematic search does not detect A-to-I RNA editing in cis-antisense RNA duplexes

  • First Published March 12, 2026
Method

Minimizing reference bias with an imputed personalized reference

  • First Published March 5, 2026
Method

Scalable cell-specific coexpression networks for granular regulatory pattern discovery with NeighbourNet

  • First Published March 5, 2026
Method

Automated interpretable artificial intelligence genomic prediction with AIGP

  • First Published March 5, 2026
Resource

Single-nucleus multiomic profiling of the aging mouse substantia nigra reveals conserved gene alterations linked to Parkinson's disease

  • First Published March 4, 2026
Research

cis-regulatory modules acting during vertebrate organogenesis" > Functional genomics analysis of developing zebrafish and human endoderm reveals highly conserved cis-regulatory modules acting during vertebrate organogenesis

  • First Published March 4, 2026
Research

Dynamic A-to-I RNA editing in response to gut microbiome in honey bees

  • First Published March 4, 2026
Research

Confounding factors in assessing the enriched expression of somatic mutant alleles in bulk tumor samples

  • First Published March 4, 2026
Erratum

Erratum: Expanded methylome and quantitative trait loci detection by long-read profiling of personal DNA

  • First Published March 2, 2026
Method

Gene duplication is associated with gene diversification and potential neofunctionalization in lung cancer evolution

  • First Published February 19, 2026
Method

Robust and efficient annotation of cell states through gene signature scoring

  • First Published February 18, 2026
Review

A systematic guide for identifying transcription factors that directly regulate the expression of a gene of interest

  • First Published February 17, 2026
Method

Mapping and quantifying nascent transcript start sites using TT-TSS-seq

  • First Published February 17, 2026
Research

Assessing the readiness of Oxford Nanopore sequencing for clinical genomics applications

  • First Published February 11, 2026
Research

Drosophila species" > Transposable elements contribute to the evolution of host shift–related genes in cactophilic Drosophila species

  • First Published February 10, 2026
Method

Analysis of coding gene expression from small RNA sequencing

  • First Published February 10, 2026
Method

spRefine denoises and imputes spatial transcriptomic data with a reference-free framework powered by genomic language model

  • First Published February 3, 2026
Corrigendum

Corrigendum: Machine learning identifies activation of RUNX/AP-1 as drivers of mesenchymal and fibrotic regulatory programs in gastric cancer

  • First Published February 3, 2026
Resource

Tetrahymena" > A systems view on DNA damage response kinetics in Tetrahymena

  • First Published January 28, 2026
Research

Degrees of convergent evolution in rodent adaptations to arid environments

  • First Published January 21, 2026
Resource

Cell type–specific gene regulatory atlas prioritizes drug targets and repurposable medicines in Alzheimer's disease

  • First Published January 21, 2026
Method

Autoencoders for genomic variation analysis

  • First Published January 20, 2026
Method

scSHEFT enables multiomics label transfer from scRNA-seq to scATAC-seq through dual alignment

  • First Published January 20, 2026
Review

Recent advances in methods to characterize archaic introgression in modern humans

  • First Published January 16, 2026
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