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Method

Dual-contrastive learning for spatial domain identification in spatial transcriptomics with STAMGC

  • First Published September 16, 2026
Method

Unifying multimodal single-cell data with a mixture-of-experts β-variational autoencoder framework

  • First Published September 16, 2026
Resource

SwinePan for pig graph-based pangenome and multiomics data mining

  • First Published September 16, 2026
Method

Resolving missing human polymorphic inversions and other complex variants from ultra-long read data

  • First Published September 1, 2026
Method

Identification of differential topologically associating domains from low sequencing depth and pseudo-bulk chromatin contact maps

  • First Published August 28, 2026
Method

Robust annotation and discovery of novel cell types in single-cell ATAC-seq data through cross-modal reference alignment

  • First Published August 28, 2026
Method

Achieving spatial multiomics diagonal integration from unaligned serial sections with DIME

  • First Published August 26, 2026
Research

A network of steroid receptor transcription factors regulates ovarian chromatin remodeling in the transition to ovulation

  • First Published August 25, 2026
Method

Bayesian inference of lineage trees by joint analysis of single-cell multimodal lineage-tracing data with BiLinT

  • First Published August 21, 2026
Method

A biobank-scale method for learning modulators of gene-environment interaction underlying human complex traits from multiple environmental exposures

  • First Published August 18, 2026
Research

Nuclear mitochondrial sequences in great ape telomere-to-telomere genomes

  • First Published August 18, 2026
Research

Massively parallel characterization of adolescent idiopathic scoliosis risk variants

  • First Published August 17, 2026
Research

Private information leakage from polygenic risk scores

  • First Published August 17, 2026
Research

Characterizing intra- and intertumor heterogeneity in ovarian high-grade serous carcinoma subtypes using single-cell and spatial transcriptomics

  • First Published August 17, 2026
Resource

A pangenome framework uncovers the role of deletions in repeated evolution of cave-derived traits

  • First Published August 13, 2026
Method

Detecting somatic mutations in rare clones using single-cell multiomics

  • First Published August 13, 2026
Method

A SNP panel for coanalysis of capture and shotgun ancient DNA data

  • First Published August 12, 2026
Method

Pattern-Filter structural validation of single-cell RNA-seq reads reduces artifactual barcodes and improves biological resolution

  • First Published August 12, 2026
Resource

Uniform processing and analysis of IGVF massively parallel reporter assay data with MPRAsnakeflow

  • First Published August 11, 2026
Research

Fetal signatures in the 3D genome of iPSC-derived neurons and their implications for disease modeling

  • First Published August 3, 2026
Research

MEIS1 in conferring sleep abnormalities and impaired cerebellar development" > Cross-species variant-to-function analyses implicate MEIS1 in conferring sleep abnormalities and impaired cerebellar development

  • First Published July 30, 2026
Research

Moderated designs can balance between batch-effect mitigation and cell loss due to hashtag-assisted pooling in single-cell experiments

  • First Published July 30, 2026
Method

Knowledge-driven interpretable neural networks provide mechanistic insight

  • First Published July 24, 2026
Method

Fast and memory efficient partial order alignment with minipoa

  • First Published July 24, 2026
In memoriam

Jim Watson (1928–2025): a genomics visionary

  • First Published July 23, 2026
Method

Multisource omic alignment and biological feature discovery with Performer encoder and triplet networks

  • First Published July 22, 2026
Method

Mosaic integration of spatial multiomic data based on hierarchical graph contrastive learning with SpatialMOSI

  • First Published July 22, 2026
Research

Methylation variability and LINE-1 transcriptional activation in multiple myeloma

  • First Published July 17, 2026
Research

Identification of genomic features that uniquely impact estrogen receptor alpha binding and its effects on gene expression in endometrial cancer

  • First Published July 17, 2026
Method

ComicGTN infers disease-associated rare cell states from single-cell multiomic data using DNA sequence–augmented graph transformer networks

  • First Published July 17, 2026
Research

Genome-wide crossover analysis in the holocentric pantry moth reveals strong crossover assurance and interference during spermatogenesis

  • First Published July 16, 2026
Method

A sequence-based classifier distinguishes phenotype-associated genes from other gene models in plants

  • First Published July 14, 2026
Research

The impact of sex, age, and genetic ancestry on DNA methylation across tissues

  • First Published July 14, 2026
Research

An RNA polymerase III tissue and tumor atlas uncovers context-specific activities linked to 3D epigenome regulatory mechanisms

  • First Published July 13, 2026
Method

Biobank-scale genotype similarity search and dynamic patient-matched cohort creation with GenoSiS

  • First Published July 10, 2026
Method

De novo structural variants in autism spectrum disorder disrupt distal regulatory interactions of neuronal genes

  • First Published July 8, 2026
Resource

Dietary effects on cytosolic and mitochondrial tRNA abundance and modification patterns across mouse tissues

  • First Published July 8, 2026
Research

Long-read sequencing reveals widespread novel splicing and neojunction-derived neoantigens in nasopharyngeal carcinoma

  • First Published July 8, 2026
Corrigendum

Corrigendum: Characterizing cytosine methylation of polymorphic transposable element insertions using the human pangenome resources

  • First Published July 7, 2026
Corrigendum

Corrigendum: Evaluation of strategies for evidence-driven genome annotation using long-read RNA-seq

  • First Published July 7, 2026
Corrigendum

Corrigendum: Systematic evaluation of the effect of polyadenylation signal variants on the expression of disease-associated genes

  • First Published July 7, 2026
Method

High-accuracy SNV calling for bacterial isolates using deep learning with AccuSNV

  • First Published July 6, 2026
Resource

Complete sequencing of medaka genomes reveals the architecture of centromeric satellites, giant mobile elements, and sex chromosomes

  • First Published July 1, 2026
Research

Convergence and conflict among telomere-specialized transposons across 60 million years of Drosophilid evolution

  • First Published July 1, 2026
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