Volume 36, Issue 1 | January 2026

Review
- - The superpowers of imprinting control regions
    Bertille Montibus
    Franck Court
    Philippe Arnaud
    First Published December 10, 2025
Research
- - Loss of multilevel 3D genome organization during breast cancer progression
    Roberto Rossini
    Saleh Oshaghi
    Maxim Nekrasov
    Aurélie Bellanger
    Renae Domaschenz
    Yasmin Dijkwel Mohamed Abdelhalim Rahul Agrawal Marit Ledsaak
    ...[+4 authors]...,
    Philippe Collas
    Ragnhild Eskeland
    David Tremethick
    Jonas Paulsen
    First Published October 9, 2025
  - Epigenetic and evolutionary features of ape subterminal heterochromatin
    DongAhn Yoo
    Katherine M. Munson
    Evan E. Eichler
    First Published October 22, 2025
  - Modest increase in the de novo single-nucleotide mutation rate in house mice born by assisted reproduction
    Laura Blanco-Berdugo
    Alexis Garretson
    Beth L. Dumont
    First Published November 13, 2025
  - Dynamic metabolic and molecular changes during seasonal shrinking in Sorex araneus
    William R. Thomas
    Cecilia Baldoni
    Yuanyuan Zeng
    David Carlson
    Julie Holm-Jacobsen
    Marion Muturi Dominik von Elverfeldt Tue B. Bennike
    ...[+3 authors]...,
    Dina K.N. Dechmann
    John Nieland
    Angelique P. Corthals
    Liliana M. Dávalos
    First Published November 4, 2025
  - Strong bias in long-read sequencing prevents assembly of Drosophila melanogaster Y-linked genes
    A. Bernardo Carvalho
    Bernard Y. Kim
    Fabiana Uno
    First Published October 1, 2025
  - Cell-type- and chromosome-specific chromatin landscapes and DNA replication programs of Drosophila testis tumor stem cell–like cells
    Jennifer A. Urban
    Daniel Ringwalt
    John M. Urban
    Wingel Xue
    Ryan Gleason
    First Published December 10, 2025
  - Polycomb misregulation in enterocytes drives tissue decline in the aging Drosophila intestine
    Sarah M. Leichter
    Kami Ahmad
    Steven Henikoff
    First Published November 17, 2025
  - Genome-wide nucleosome and transcription factor responses to genetic perturbations reveal chromatin-mediated mechanisms of transcriptional regulation
    Kevin Moyung
    Yulong Li
    Heather K. MacAlpine
    Alexander J. Hartemink
    David M. MacAlpine
    First Published December 9, 2025
Methods
- - Automated chromatin profiling with spa-ChIP-seq uncovers the impacts of condition variations
    Yuwei Cao
    Lauren Patel
    Lauren Alcoser
    Eric Mendenhall
    Christopher Benner
    First Published December 12, 2025
  - Recovering gene regulatory networks in single-cell multi-omics data with PRISM-GRN
    Wenhao Zhang
    Lan Cao
    Xiaoxuan Gu
    Yongyu Long
    Ying Wang
    First Published October 9, 2025
  - Statistically rigorous and computationally efficient chromatin stripe detection with Quagga
    Fan Feng
    Sean Moran
    Anders S. Hansen
    Xiaotian Zhang
    Jie Liu
    First Published November 12, 2025
  - A versatile type VI CRISPR-based approach for targeted m6A demethylation in mRNAs
    Panagiotis G. Adamopoulos
    Konstantina Athanasopoulou
    Andreas Scorilas
    First Published December 11, 2025
  - Genome-wide maps of CPD deamination in yeast reveal the impact of DNA sequence context and nucleosome architecture on cytosine deamination rates
    Marian F. Laughery
    Bastian Stark
    Benjamin Morledge-Hampton
    Steven A. Roberts
    John J. Wyrick
    First Published December 9, 2025
  - Integration of high-throughput proteomic data and complementary omics layers with PriOmics
    Robin Kosch
    Katharina Limm
    Annette M. Staiger
    Nadine S. Kurz
    Nicole Seifert
    Bence Oláh Stefan Solbrig Viola Poeschel Gerhard Held Marita Ziepert Norbert Schmitz Emil Chteinberg Reiner Siebert Rainer Spang
    ...[+9 authors]...,
    Helena U. Zacharias
    German Ott
    Peter J. Oefner
    Michael Altenbuchinger
    First Published November 18, 2025
  - Predicted protein 3D structures provide essential insights into the genetic architecture underlying phenotypic diversity in maize
    Shuai Wang
    Merritt Khaipho-Burch
    Lynn C. Johnson
    Zachary R. Miller
    Peter J. Bradbury
    Doug Speed William J. Allen M. Cinta Romay
    ...[+3 authors]...,
    Jiquan Xue
    Edward S. Buckler
    Guillaume P. Ramstein
    Baoxing Song
    First Published October 31, 2025
Resource
- - The PanOryza pangene catalog of Asian cultivated rice
    Bruno Contreras-Moreira
    Eshan Sharma
    Shradha Saraf
    Guy Naamati
    Parul Gupta
    Justin Elser Dmytro Chebotarov Kapeel Chougule Zhenyuan Lu Sharon Wei Andrew Olson Ian Tsang Disha Lodha Yong Zhou Zhichao Yu Wen Zhao Jianwei Zhang Sandeep Amberkar Kawinnat Sue-Ob Zhi Sun Maria Martin Kenneth L. McNally Doreen Ware Eric W. Deutsch Dario Copetti
    ...[+20 authors]...,
    Rod A. Wing
    Pankaj Jaiswal
    Sarah Dyer
    Andrew R. Jones
    First Published December 12, 2025

Table of Contents

Volume 36, Issue 1 | January 2026

Review

The superpowers of imprinting control regions

Research

Loss of multilevel 3D genome organization during breast cancer progression

Epigenetic and evolutionary features of ape subterminal heterochromatin

Modest increase in the de novo single-nucleotide mutation rate in house mice born by assisted reproduction

Dynamic metabolic and molecular changes during seasonal shrinking in Sorex araneus

Strong bias in long-read sequencing prevents assembly of Drosophila melanogaster Y-linked genes

Cell-type- and chromosome-specific chromatin landscapes and DNA replication programs of Drosophila testis tumor stem cell–like cells

Polycomb misregulation in enterocytes drives tissue decline in the aging Drosophila intestine

Genome-wide nucleosome and transcription factor responses to genetic perturbations reveal chromatin-mediated mechanisms of transcriptional regulation

Methods

Automated chromatin profiling with spa-ChIP-seq uncovers the impacts of condition variations

Recovering gene regulatory networks in single-cell multi-omics data with PRISM-GRN

Statistically rigorous and computationally efficient chromatin stripe detection with Quagga

A versatile type VI CRISPR-based approach for targeted m6A demethylation in mRNAs

Genome-wide maps of CPD deamination in yeast reveal the impact of DNA sequence context and nucleosome architecture on cytosine deamination rates

Integration of high-throughput proteomic data and complementary omics layers with PriOmics

Predicted protein 3D structures provide essential insights into the genetic architecture underlying phenotypic diversity in maize

Resource

The PanOryza pangene catalog of Asian cultivated rice

Table of Contents

Volume 36, Issue 1 | January 2026

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Review

Research

Methods

Resource