Volume 36, Issue 7 | July 2026

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Perspective
- - The Topological Regulatory Logic of noncoding RNA–mediated gene expression
    Thomas R. Gingeras
    First Published June 17, 2026
Research
- - Whole-genome variant detection in long-read sequencing data from ultralow input patient samples
    Katherine Wang
    Cera J. Aex
    Hayan Lee
    Lucas Finot
    Kevin Zhu
    Julianna R. Chang Aaron M. Horning William J. Rowell
    ...[+3 authors]...,
    Philip Li
    Sarah B. Kingan
    Michael P. Snyder
    Graham S. Erwin
    First Published May 28, 2026
  - Influence of cis-regulatory elements on expression divergence in human segmental duplications
    Colin J. Shew
    Gulhan Kaya
    Sean P. McGinty
    Megan Y. Dennis
    First Published June 16, 2026
  - Single-cell transcriptomics reveals rapid divergence of genes guiding meiosis and spermiogenesis in two passerine birds
    J. Carolina Segami
    Marie Sémon
    Catarina Cunha
    Claudia Bergin
    Carina F. Mugal
    First Published May 14, 2026
  - Interplay between purging and admixture shapes genetic load in an invasive guppy population
    Katarzyna Burda
    Mary J. Janecka
    Ryan S. Mohammed
    David R. Clark
    Rachael Kramp
    First Published May 20, 2026
  - Genome evolution in parthenogenetic nematodes shaped by chromosome rearrangements and introgression
    George Chung
    Lewis Stevens
    Xiaoguang Dai
    Scott Hickey
    Karin Kiontke
    Priyesh Rughani Manuela R. Kieninger Joanna C. Collins Sissel Juul
    ...[+4 authors]...,
    Fabio Piano
    David H.A. Fitch
    Mark Blaxter
    Kristin C. Gunsalus
    First Published May 29, 2026
  - Structural variants are enriched in deleterious visible phenotypes in Drosophila
    Alejandra Samano
    Matthew Musat
    Mihir Junaghare
    Asad Ahmad
    Mehlum Ali
    Sebastian Alves Sreeram Pasupuleti Jelisha Perera Omar Saada
    ...[+4 authors]...,
    Brady Sabido
    Trevor Smith
    Sophie Walz
    Mahul Chakraborty
    First Published May 14, 2026
  - Spatially resolved profiling of steroid nuclear receptors reveals a role for the disordered N-terminal domains in genome targeting and AP-1 interaction
    Inbal Zigdon
    Achinoam Shoham
    Vladimir Mindel
    Wajd Manadre
    David Jan
    First Published June 22, 2026
Methods
- - Transfer learning enhances clinical utility of polygenic scores with small, phenotypically refined cohorts
    YuChung Lin
    Christoph Patrick Beier
    Zuzana Sobiskova
    Khalid Hamandi
    Tommy Stödberg
    Ching Ching Ng Danielle M. Andrade Marte Roa Syvertsen Elena Gardella Alessandro Orsini Choong Yi Fong Jana Zarubova Michaela Kajsová Kheng Seang Lim Kaja Kristine Selmer Emanuele Cerulli Irelli
    ...[+11 authors]...,
    Guido Rubboli
    Pasquale Striano
    Deb K. Pal
    Lisa J. Strug
    First Published June 2, 2026
  - Locations of consecutive G•C base pairs direct genomic nucleosome positioning
    Hiroaki Kato
    Tomohiro Fuse
    Shoko Sato
    Yohei Kurihara
    Wataru Kagawa
    First Published June 25, 2026
  - MAPLE enables ultrasensitive detection of low-frequency cfDNA methylation haplotypes using short capture probes with cost-efficient performance
    Nina G. Xie
    Yangjunyi Li
    Xiaowen He
    Liyuan Zhao
    Ying Mei
    Jingjing Hou Xiaosheng He Shuang Guo Lingjian Yang Xiurui Zhu Congchong Wei Zhihui Xu Yalong Zhang
    ...[+8 authors]...,
    Min Li
    Yonghui Li
    Xueguang Sun
    Ping Lan
    First Published June 16, 2026
  - Flexible and scalable inference of spatially varying correlation in spatial transcriptomics with spCorr
    Chenxin Flora Jiang
    Yuxin Yin
    Paul Robson
    Yuanhao James Li
    Jingyi Jessica Li
    First Published June 17, 2026
  - Spatially informed reference-free cell-type deconvolution for spatial transcriptomics with SpatialCD
    Phuong Vo
    Yuehua Cui
    First Published June 22, 2026
  - Reference-informed spatial domain detection using weak supervision for spatial transcriptomics
    Xin Ma
    Weijia Jin
    Qing Lu
    Ramon C. Sun
    Li Chen
    First Published June 3, 2026
  - Augmenting transcriptome annotations through the lens of splicing evolution
    Xiaofei Carl Zang
    Ke Chen
    Irtesam Mahmud Khan
    Mingfu Shao
    First Published May 29, 2026
  - Cultivation-independent high-quality microbial genome reconstruction from environmental samples with midi-metagenomics
    John Vollmers
    Maximiano Correa Cassal
    Anne-Kristin Kaster
    First Published May 15, 2026
Resource
- - A comprehensive single-cell atlas of monoallelic expression across various tissues in zebrafish
    Hui Zeng
    Zhan Liu
    Huimin Xiang
    Boliang Liu
    Di Zhang
    First Published May 28, 2026
Corrigenda
- - Corrigendum: Characterizing cytosine methylation of polymorphic transposable element insertions using the human pangenome resources
    Xiaoyu Zhuo
    Chad Tomlinson
    Edward A. Belter
    Prashant Kumar Kuntala
    Wesley N. Saintilnord
    Juan Jiang
    ...[+1 authors]...,
    Tina Lindsay
    Juan F. Macias-Velasco
    Robert S. Fulton
    Ting Wang
    First Published July 7, 2026
  - Corrigendum: Evaluation of strategies for evidence-driven genome annotation using long-read RNA-seq
    Alejandro Paniagua
    Cristina Agustín-García
    Francisco J. Pardo-Palacios
    Thomas Brown
    Maite De Maria
    First Published July 7, 2026
  - Corrigendum: Systematic evaluation of the effect of polyadenylation signal variants on the expression of disease-associated genes
    Meng Chen
    Ran Wei
    Gang Wei
    Mingqing Xu
    Zhixi Su
    First Published July 7, 2026

Table of Contents

Volume 36, Issue 7 | July 2026

Perspective

The Topological Regulatory Logic of noncoding RNA–mediated gene expression

Research

Whole-genome variant detection in long-read sequencing data from ultralow input patient samples

Influence of cis-regulatory elements on expression divergence in human segmental duplications

Single-cell transcriptomics reveals rapid divergence of genes guiding meiosis and spermiogenesis in two passerine birds

Interplay between purging and admixture shapes genetic load in an invasive guppy population

Genome evolution in parthenogenetic nematodes shaped by chromosome rearrangements and introgression

Structural variants are enriched in deleterious visible phenotypes in Drosophila

Spatially resolved profiling of steroid nuclear receptors reveals a role for the disordered N-terminal domains in genome targeting and AP-1 interaction

Methods

Transfer learning enhances clinical utility of polygenic scores with small, phenotypically refined cohorts

Locations of consecutive G•C base pairs direct genomic nucleosome positioning

MAPLE enables ultrasensitive detection of low-frequency cfDNA methylation haplotypes using short capture probes with cost-efficient performance

Flexible and scalable inference of spatially varying correlation in spatial transcriptomics with spCorr

Spatially informed reference-free cell-type deconvolution for spatial transcriptomics with SpatialCD

Reference-informed spatial domain detection using weak supervision for spatial transcriptomics

Augmenting transcriptome annotations through the lens of splicing evolution

Cultivation-independent high-quality microbial genome reconstruction from environmental samples with midi-metagenomics

Resource

A comprehensive single-cell atlas of monoallelic expression across various tissues in zebrafish

Corrigenda

Corrigendum: Characterizing cytosine methylation of polymorphic transposable element insertions using the human pangenome resources

Corrigendum: Evaluation of strategies for evidence-driven genome annotation using long-read RNA-seq

Corrigendum: Systematic evaluation of the effect of polyadenylation signal variants on the expression of disease-associated genes

Table of Contents

Volume 36, Issue 7 | July 2026

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Perspective

Research

Methods

Resource

Corrigenda