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Method

Single-cell transcriptome analysis reveals onco-fetal reprogramming with implications for drug resistance and clinical outcome

  • First Published October 9, 2026
Method

Protein large language model–assisted one-to-one gene homology mapping in cross-species single-cell transcriptome integration

  • First Published October 9, 2026
Research

Temporal transcriptomics identifies transregulation by multiple lncRNAs in human iPSCs

  • First Published October 9, 2026
Research

Error correction algorithms for efficient gene expression quantification in single cell transcriptomics with Arcane

  • First Published October 7, 2026
Research

Shared transcriptional consequences of epigenetic machinery disruption in murine neuronal progenitors

  • First Published October 7, 2026
Research

Meso-scale spatial analysis of papilloma formation and clonal expansion in cancerized skin

  • First Published October 1, 2026
Method

Fast and accurate construction of multiple sequence alignments from protein language embeddings with ARIES

  • First Published October 1, 2026
Method

Optical genome mapping identifies clinically relevant somatic structural variation in epilepsy-affected brain tissue

  • First Published October 1, 2026
Method

Scaling coalescent-based species tree inference to 100,000 taxa with STELAR-X

  • First Published October 1, 2026
Corrigendum

Corrigendum: Profiling the long noncoding RNA interaction network in the regulatory elements of target genes by chromatin in situ reverse transcription sequencing

  • First Published October 1, 2026
Research

Dissecting functional regulatory convergence over 160 million years of therian evolution

  • First Published September 23, 2026
Method

Viral haplotype reconstruction from long reads with virCHap

  • First Published September 23, 2026
Method

Multilevel ensemble for genome-wide prediction of cell-specific G-quadruplexes utilizing transformed sequences and enhanced chromatin accessibility with G4Beacon2

  • First Published September 22, 2026
Method

Decoding cell division history and lineage-resolved phenotypic patterns from single-cell barcode and transcriptomic data

  • First Published September 21, 2026
Method

Deep genomic models of allele-specific measurements

  • First Published September 21, 2026
Research

Spatial genome organization in nematodes with programmed DNA elimination

  • First Published September 21, 2026
Method

CircExor enables interpretable prediction of circRNA localization into extracellular vesicles

  • First Published September 17, 2026
Method

Unifying multimodal single-cell data with a mixture-of-experts β-variational autoencoder framework

  • First Published September 16, 2026
Method

Dual-contrastive learning for spatial domain identification in spatial transcriptomics with STAMGC

  • First Published September 16, 2026
Resource

SwinePan for pig graph-based pangenome and multiomics data mining

  • First Published September 16, 2026
Method

Resolving missing human polymorphic inversions and other complex variants from ultralong read data

  • First Published September 1, 2026
Method

Identification of differential topologically associating domains from low sequencing depth and pseudobulk chromatin contact maps

  • First Published August 28, 2026
Method

Robust annotation and discovery of novel cell types in single-cell ATAC-seq data through cross-modal reference alignment

  • First Published August 28, 2026
Method

Achieving spatial multiomics diagonal integration from unaligned serial sections with DIME

  • First Published August 26, 2026
Research

A network of steroid receptor transcription factors regulates ovarian chromatin remodeling in the transition to ovulation

  • First Published August 25, 2026
Method

Bayesian inference of lineage trees by joint analysis of single-cell multimodal lineage-tracing data with BiLinT

  • First Published August 21, 2026
Method

A biobank-scale method for learning modulators of gene-environment interaction underlying human complex traits from multiple environmental exposures

  • First Published August 18, 2026
Research

Nuclear mitochondrial sequences in great ape telomere-to-telomere genomes

  • First Published August 18, 2026
Research

Private information leakage from polygenic risk scores

  • First Published August 17, 2026
Research

Massively parallel characterization of adolescent idiopathic scoliosis risk variants

  • First Published August 17, 2026
Research

Characterizing intra- and intertumor heterogeneity in ovarian high-grade serous carcinoma subtypes using single-cell and spatial transcriptomics

  • First Published August 17, 2026
Resource

A pangenome framework uncovers the role of deletions in repeated evolution of cave-derived traits

  • First Published August 13, 2026
Method

Detecting somatic mutations in rare clones using single-cell multiomics

  • First Published August 13, 2026
Method

A SNP panel for coanalysis of capture and shotgun ancient DNA data

  • First Published August 12, 2026
Method

Pattern-Filter structural validation of single-cell RNA-seq reads reduces artifactual barcodes and improves biological resolution

  • First Published August 12, 2026
Resource

Uniform processing and analysis of IGVF massively parallel reporter assay data with MPRAsnakeflow

  • First Published August 11, 2026
Research

Fetal signatures in the 3D genome of iPSC-derived neurons and their implications for disease modeling

  • First Published August 3, 2026
Research

MEIS1 in conferring sleep abnormalities and impaired cerebellar development" > Cross-species variant-to-function analyses implicate MEIS1 in conferring sleep abnormalities and impaired cerebellar development

  • First Published July 30, 2026
Research

Moderated designs can balance between batch-effect mitigation and cell loss due to hashtag-assisted pooling in single-cell experiments

  • First Published July 30, 2026
Method

Knowledge-driven interpretable neural networks provide mechanistic insight

  • First Published July 24, 2026
Method

Fast and memory efficient partial order alignment with minipoa

  • First Published July 24, 2026
In memoriam

Jim Watson (1928–2025): a genomics visionary

  • First Published July 23, 2026
Method

Multisource omic alignment and biological feature discovery with Performer encoder and triplet networks

  • First Published July 22, 2026
Method

Mosaic integration of spatial multiomic data based on hierarchical graph contrastive learning with SpatialMOSI

  • First Published July 22, 2026
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