Volume 36, Issue 10 | October 2026

This is the current issue. View archive

Research
- - Nuclear mitochondrial sequences in great ape telomere-to-telomere genomes
    Edmundo Torres-González
    Marzia A. Cremona
    Jessica M. Storer
    Mario Ventura
    Rachel J. O'Neill
    Kateryna D. Makova
    First Published August 18, 2026
  - Massively parallel characterization of adolescent idiopathic scoliosis risk variants
    Darius Ramkhalawan
    Justin Koesterich
    Fahim Rejanur Tasin
    Carlos Cuna
    Anat Kreimer
    Nadja Makki
    First Published August 17, 2026
  - Fetal signatures in the 3D genome of iPSC-derived neurons and their implications for disease modeling
    Diana R. Zagirova
    Anna D. Kononkova
    Kirill V. Morozov
    Maria N. Molodova
    Nikita S. Vaulin
    Anastasiia V. Dudkovskaia Polina I. Dozorova Olga I. Efimova Anna V. Tvorogova Kirill A. Ulianov Philipp E. Khaitovich
    ...[+6 authors]...,
    Sergey V. Razin
    Maria A. Lagarkova
    Sergey V. Ulianov
    Ekaterina E. Khrameeva
    First Published August 3, 2026
  - A network of steroid receptor transcription factors regulates ovarian chromatin remodeling in the transition to ovulation
    Doan T. Dinh
    Rebecca L. Robker
    Darryl L. Russell
    First Published August 25, 2026
  - Characterizing intra- and intertumor heterogeneity in ovarian high-grade serous carcinoma subtypes using single-cell and spatial transcriptomics
    Weishan Li
    Laurie Grieshober
    Jason Gertz
    Adriana Ivich
    Jennifer A. Doherty
    Casey S. Greene
    Stephanie C. Hicks
    First Published August 17, 2026
  - Moderated designs can balance between batch-effect mitigation and cell loss due to hashtag-assisted pooling in single-cell experiments
    Budha Chatterjee
    Katrina Gorga
    Carly Blair
    Yuko Ohta
    Michelle Radov
    Elizabeth M. Hill
    Christopher T. Boughter
    Martin Meier-Schellersheim
    Nevil J. Singh
    First Published July 30, 2026
Methods
- - Robust annotation and discovery of novel cell types in single-cell ATAC-seq data through cross-modal reference alignment
    Lan Cao
    Wenhao Zhang
    Feng Zhou
    Yushuang He
    Yongyu Long
    Shengquan Chen
    Ying Wang
    First Published August 28, 2026
  - Bayesian inference of lineage trees by joint analysis of single-cell multimodal lineage-tracing data with BiLinT
    Ziwei Chen
    Bingwei Zhang
    Linrui Tang
    Fuzhou Gong
    Lin Wan
    Liang Ma
    First Published August 21, 2026
  - Unifying multimodal single-cell data with a mixture-of-experts β-variational autoencoder framework
    Andrew J. Ashford
    Trevor Enright
    Julia Somers
    Olga Nikolova
    Emek Demir
    First Published September 16, 2026
  - Dual-contrastive learning for spatial domain identification in spatial transcriptomics with STAMGC
    Zhuoyue Zhang
    Qianmao Wen
    Junlin Xu
    Yajie Meng
    Feifei Cui
    Zilong Zhang
    First Published September 16, 2026
  - Accurate reconstruction of spatial cell-type maps and characterization of domain-specific functions based on a gene-aware heterogeneous network
    Zilin Li
    Zhaoyang Huang
    Yan Li
    Chenguang Zhao
    Liang Yu
    First Published August 25, 2026
  - Resolving missing human polymorphic inversions and other complex variants from ultralong read data
    Ricardo Moreira-Pinhal
    Konstantinos Karakostis
    Illya Yakymenko
    Oscar Conchillo
    Maria Díaz-Ros
    Andrés Santos
    ...[+1 authors]...,
    Miquel Àngel Senar
    Jaime Martínez-Urtaza
    Marta Puig
    Mario Cáceres
    First Published September 1, 2026
  - Identification of differential topologically associating domains from low sequencing depth and pseudobulk chromatin contact maps
    Junping Li
    Han Xu
    Hebing Chen
    Jiadong Lin
    Yusen Ye
    Lin Gao
    First Published August 28, 2026
  - Multilevel ensemble for genome-wide prediction of cell-specific G-quadruplexes utilizing transformed sequences and enhanced chromatin accessibility with G4Beacon2
    Tiantong Tao
    Rongxin Zhang
    Huiling Shu
    Yuqing Ma
    Zhuofan Zhang
    Jing Tu
    Xiao Sun
    First Published September 22, 2026
  - CircExor enables interpretable prediction of circRNA localization into extracellular vesicles
    Yusa Zhang
    Hanbo Lu
    Pengfei Bao
    Anhao Wang
    Xiaohong Lyu
    Yidong Zhou
    Songjie Shen
    Zhi John Lu
    First Published September 17, 2026
Resource
- - T2T genomes of Caenorhabditis nigoni and Caenorhabditis briggsae reveal divergence in satellite DNA abundance
    Ryan Pellow
    Manitejus Kotikalapudi
    Ofer Rog
    First Published September 4, 2026
Corrigendum
- - Corrigendum: Profiling the long noncoding RNA interaction network in the regulatory elements of target genes by chromatin in situ reverse transcription sequencing
    Shilin Zhang
    Yichen Wang
    Lin Jia
    Xue Wen
    Zhonghua Du
    Cong Wang Yajing Hao Dehai Yu Lei Zhou Naifei Chen Jingcheng Chen Huiling Chen Hui Zhang Ilkay Celik Günhan Gülsoy Jianjun Luo Baoming Qin Xueling Cui Zhonghui Liu Songling Zhang Miguel A. Esteban Ferhat Ay Wei Xu Runsheng Chen
    ...[+19 authors]...,
    Wei Li
    Andrew R. Hoffman
    Ji-Fan Hu
    Jiuwei Cui
    First Published October 1, 2026

About the Cover

← Previous Issue

Table of Contents

Volume 36, Issue 10 | October 2026

Research

Nuclear mitochondrial sequences in great ape telomere-to-telomere genomes

Massively parallel characterization of adolescent idiopathic scoliosis risk variants

Fetal signatures in the 3D genome of iPSC-derived neurons and their implications for disease modeling

A network of steroid receptor transcription factors regulates ovarian chromatin remodeling in the transition to ovulation

Characterizing intra- and intertumor heterogeneity in ovarian high-grade serous carcinoma subtypes using single-cell and spatial transcriptomics

Moderated designs can balance between batch-effect mitigation and cell loss due to hashtag-assisted pooling in single-cell experiments

Methods

Robust annotation and discovery of novel cell types in single-cell ATAC-seq data through cross-modal reference alignment

Bayesian inference of lineage trees by joint analysis of single-cell multimodal lineage-tracing data with BiLinT

Unifying multimodal single-cell data with a mixture-of-experts β-variational autoencoder framework

Dual-contrastive learning for spatial domain identification in spatial transcriptomics with STAMGC

Accurate reconstruction of spatial cell-type maps and characterization of domain-specific functions based on a gene-aware heterogeneous network

Resolving missing human polymorphic inversions and other complex variants from ultralong read data

Identification of differential topologically associating domains from low sequencing depth and pseudobulk chromatin contact maps

Multilevel ensemble for genome-wide prediction of cell-specific G-quadruplexes utilizing transformed sequences and enhanced chromatin accessibility with G4Beacon2

CircExor enables interpretable prediction of circRNA localization into extracellular vesicles

Resource

T2T genomes of Caenorhabditis nigoni and Caenorhabditis briggsae reveal divergence in satellite DNA abundance

Corrigendum

Corrigendum: Profiling the long noncoding RNA interaction network in the regulatory elements of target genes by chromatin in situ reverse transcription sequencing

Table of Contents

Volume 36, Issue 10 | October 2026

Share this issue

Research

Methods

Resource

Corrigendum