Your search for returned 6,370 results
Research
A hidden layer of structural variation in transposable elements reveals potential genetic modifiers in human disease-risk loci
- First Published March 24, 2022
Method
Classification and clustering of RNA crosslink-ligation data reveal complex structures and homodimers
- First Published March 24, 2022
Method
A general framework for identifying oligogenic combinations of rare variants in complex disorders
- First Published March 17, 2022
Method
A general calculus of fitness landscapes finds genes under selection in cancers
- First Published March 17, 2022
Method
Sequencing of individual barcoded cDNAs using Pacific Biosciences and Oxford Nanopore Technologies reveals platform-specific error patterns
- First Published March 17, 2022
Research
Genome-wide transcript and protein analysis highlights the role of protein homeostasis in the aging mouse heart
- First Published March 11, 2022
Research
Paramecium" > GC content, but not nucleosome positioning, directly contributes to intron splicing efficiency in Paramecium
- First Published March 9, 2022
Research
Paramecium macronuclear genome" > Broad domains of histone marks in the highly compact Paramecium macronuclear genome
- First Published March 9, 2022
Method
Pan-human consensus genome significantly improves the accuracy of RNA-seq analyses
- First Published March 7, 2022
Method
An association test of the spatial distribution of rare missense variants within protein structures identifies Alzheimer's disease–related patterns
- First Published February 24, 2022
Method
Discovery of an unusually high number of de novo mutations in sperm of older men using duplex sequencing
- First Published February 24, 2022
Method
Identification of phenotype-specific networks from paired gene expression–cell shape imaging data
- First Published February 23, 2022
Method
A framework to score the effects of structural variants in health and disease
- First Published February 23, 2022
Method
Low-input RNase footprinting for simultaneous quantification of cytosolic and mitochondrial translation
- First Published February 22, 2022
Research
Functional noncoding SNPs in human endothelial cells fine-map vascular trait associations
- First Published February 22, 2022
Research
Somatic structural variant formation is guided by and influences genome architecture
- First Published February 17, 2022
Research
Accumulation and ineffective silencing of transposable elements on an avian W Chromosome
- First Published February 11, 2022
Research
Whole-genome resequencing of temporally stratified samples reveals substantial loss of haplotype diversity in the highly inbred Scandinavian wolf population
- First Published February 8, 2022
Method
NicE-C efficiently reveals open chromatin–associated chromosome interactions at high resolution
- First Published February 1, 2022
Research
Mendelian randomization analyses implicate biogenesis of translation machinery in human aging
- First Published January 25, 2022
Research
Joint actions of diverse transcription factor families establish neuron-type identities and promote enhancer selectivity
- First Published January 24, 2022
Resource
Mitochondrial DNA variation across 56,434 individuals in gnomAD
- First Published January 24, 2022
Research
Distal regulation, silencers, and a shared combinatorial syntax are hallmarks of animal embryogenesis
- First Published January 19, 2022
Method
Domain-adaptive neural networks improve cross-species prediction of transcription factor binding
- First Published January 18, 2022
Research
Characterization of transcript enrichment and detection bias in single-nucleus RNA-seq for mapping of distinct human adipocyte lineages
- First Published January 18, 2022
Method
Accurate and robust inference of microbial growth dynamics from metagenomic sequencing reveals personalized growth rates
- First Published January 5, 2022
Resource
Zebrafish transposable elements show extensive diversification in age, genomic distribution, and developmental expression
- First Published January 5, 2022
Review
Advancing genomic technologies and clinical awareness accelerates discovery of disease-associated tandem repeat sequences
- First Published December 29, 2021
Method
Antibody-free profiling of transcription factor occupancy during early embryogenesis by FitCUT&RUN
- First Published December 29, 2021
Resource
Anopheles coluzzii" > Transposable element variants and their potential adaptive impact in urban populations of the malaria vector Anopheles coluzzii
- First Published December 29, 2021
Research
Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states
- First Published December 28, 2021
Research
Low-frequency somatic copy number alterations in normal human lymphocytes revealed by large-scale single-cell whole-genome profiling
- First Published December 28, 2021
Research
Spatial organization of chromosomes leads to heterogeneous chromatin motion and drives the liquid- or gel-like dynamical behavior of chromatin
- First Published December 28, 2021
Method
A full-proteome, interaction-specific characterization of mutational hotspots across human cancers
- First Published December 28, 2021
Research
Genomic environments scale the activities of diverse core promoters
- First Published December 27, 2021
Research
Gene by environment interaction mouse model reveals a functional role for 5-hydroxymethylcytosine in neurodevelopmental disorders
- First Published December 23, 2021
Resource
Integration of high-resolution promoter profiling assays reveals novel, cell type–specific transcription start sites across 115 human cell and tissue types
- First Published December 23, 2021
Research
Limited allele-specific gene expression in highly polyploid sugarcane
- First Published December 23, 2021
Method
Accessible Region Conformation Capture (ARC-C) gives high-resolution insights into genome architecture and regulation
- First Published December 21, 2021
Research
Epigenomic translocation of H3K4me3 broad domains over oncogenes following hijacking of super-enhancers
- First Published December 21, 2021
Research
Long-range promoter–enhancer contacts are conserved during evolution and contribute to gene expression robustness
- First Published December 20, 2021
Research
Characteristics, origin, and potential for cancer diagnostics of ultrashort plasma cell-free DNA
- First Published December 20, 2021
Method
A systematic genome-wide account of binding sites for the model transcription factor Gcn4
- First Published December 16, 2021
Research
Reactivation of transposable elements following hybridization in fission yeast
- First Published December 14, 2021
Research
Diverse tumorigenic consequences of human papillomavirus integration in primary oropharyngeal cancers
- First Published December 13, 2021
Method
De novo individualized disease modules reveal the synthetic penetrance of genes and inform personalized treatment regimens
- First Published December 7, 2021
Resource
RefSeq Functional Elements as experimentally assayed nongenic reference standards and functional interactions in human and mouse
- First Published December 7, 2021
Research
Cell type–specific analysis by single-cell profiling identifies a stable mammalian tRNA–mRNA interface and increased translation efficiency in neurons
- First Published December 2, 2021
Method
Comprehensive determination of transcription start sites derived from all RNA polymerases using ReCappable-seq
- First Published November 23, 2021
Research
Individualized VDJ recombination predisposes the available Ig sequence space
- First Published November 23, 2021
Method
Genome-wide cancer-specific chromatin accessibility patterns derived from archival processed xenograft tumors
- First Published November 23, 2021
Research
Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits
- First Published November 23, 2021
Research
Brettanomyces bruxellensis yeast species" > Different trajectories of polyploidization shape the genomic landscape of the Brettanomyces bruxellensis yeast species
- First Published November 23, 2021
Research
Intergenic ORFs as elementary structural modules of de novo gene birth and protein evolution
- First Published November 22, 2021
Research
Delayed DNA replication in haploid human embryonic stem cells
- First Published November 22, 2021
Research
Alu insertion variants alter gene transcript levels" > Alu insertion variants alter gene transcript levels
- First Published November 19, 2021
Research
Epstein–Barr virus nuclear antigen 2 extensively rewires the human chromatin landscape at autoimmune risk loci
- First Published November 19, 2021
Research
RET regulatory code is disrupted in Hirschsprung disease" > A multi-enhancer RET regulatory code is disrupted in Hirschsprung disease
- First Published November 15, 2021
Research
Rhizophagus irregularis" > Transcriptional activity and epigenetic regulation of transposable elements in the symbiotic fungus Rhizophagus irregularis
- First Published November 12, 2021
Research
Mutagenesis of human genomes by endogenous mobile elements on a population scale
- First Published November 12, 2021
Resource
Cryptosporidium genome sequences reveal expanded transporter repertoire and duplication of entire chromosome ends including subtelomeric regions" > Long-read assembly and comparative evidence-based reanalysis of Cryptosporidium genome sequences reveal expanded transporter repertoire and duplication of entire chromosome ends including subtelomeric regions
- First Published November 11, 2021
Research
Chromosome-specific telomere lengths and the minimal functional telomere revealed by nanopore sequencing
- First Published October 26, 2021
Research
Embryonic LTR retrotransposons supply promoter modules to somatic tissues
- First Published October 21, 2021
Research
Drosophila" > Shared evolutionary trajectories of three independent neo-sex chromosomes in Drosophila
- First Published October 21, 2021
Research
Decoding the function of bivalent chromatin in development and cancer
- First Published October 19, 2021
Method
Global quantification exposes abundant low-level off-target activity by base editors
- First Published October 19, 2021
Research
Positive selection in noncoding genomic regions of vocal learning birds is associated with genes implicated in vocal learning and speech functions in humans
- First Published October 19, 2021
Research
Cellular abundance shapes function in piRNA-guided genome defense
- First Published October 19, 2021
Research
RBFOX splicing factors contribute to a broad but selective recapitulation of peripheral tissue splicing patterns in the thymus
- First Published October 14, 2021
Research
Genome-wide oscillations in G + C density and sequence conservation
- First Published October 14, 2021
Perspective
Applications of single-cell genomics and computational strategies to study common disease and population-level variation
- First Published October 1, 2021
Perspective
Cancer cell states and emergent properties of the dynamic tumor system
- First Published October 1, 2021
Research
Structural variants are a major source of gene expression differences in humans and often affect multiple nearby genes
- First Published September 20, 2021
Research
Evolutionary rewiring of the wheat transcriptional regulatory network by lineage-specific transposable elements
- First Published September 9, 2021
Method
Efficient computation of Faith's phylogenetic diversity with applications in characterizing microbiomes
- First Published September 3, 2021
Method
Cancer-associated dynamics and potential regulators of intronic polyadenylation revealed by IPAFinder using standard RNA-seq data
- First Published September 2, 2021
Research
Nuclease deficiencies alter plasma cell-free DNA methylation profiles
- First Published September 1, 2021