Volume 32, Issue 4 | April 2022

In memoriam
- - Haig H. Kazazian, Jr. (1937–2022)
    Stylianos E. Antonarakis
    Stuart H. Orkin
    First Published March 21, 2022
Commentary
- - Implications of the first complete human genome assembly
    First Published March 31, 2022
Perspectives
- - Short arms of human acrocentric chromosomes and the completion of the human genome sequence
    Stylianos E. Antonarakis
    First Published March 31, 2022
  - The genetics and epigenetics of satellite centromeres
    Paul B. Talbert
    Steven Henikoff
    First Published March 31, 2022
Research
- - Chromosome-specific telomere lengths and the minimal functional telomere revealed by nanopore sequencing
    Samantha L. Sholes
    Kayarash Karimian
    Ariel Gershman
    Thomas J. Kelly
    Winston Timp
    First Published October 26, 2021
  - MYC overexpression leads to increased chromatin interactions at super-enhancers and MYC binding sites
    Yi Xiang See
    Kaijing Chen
    Melissa J. Fullwood
    First Published February 3, 2022
  - Somatic structural variant formation is guided by and influences genome architecture
    Nikos Sidiropoulos
    Balca R. Mardin
    F. Germán Rodríguez-González
    Ivan D. Bochkov
    Shilpa Garg
    First Published February 17, 2022
  - A hidden layer of structural variation in transposable elements reveals potential genetic modifiers in human disease-risk loci
    Elisabeth J. van Bree
    Rita L.F.P. Guimarães
    Mischa Lundberg
    Elena R. Blujdea
    Jimi L. Rosenkrantz
    Fred T.G. White Josse Poppinga Paula Ferrer-Raventós Anne-Fleur E. Schneider Isabella Clayton David Haussler Marcel J.T. Reinders
    ...[+7 authors]...,
    Henne Holstege
    Adam D. Ewing
    Colette Moses
    Frank M.J. Jacobs
    First Published March 24, 2022
  - Accumulation and ineffective silencing of transposable elements on an avian W Chromosome
    Vera M. Warmuth
    Matthias H. Weissensteiner
    Jochen B.W. Wolf
    First Published February 11, 2022
  - The role of insulators and transcription in 3D chromatin organization of flies
    Keerthi T. Chathoth
    Liudmila A. Mikheeva
    Gilles Crevel
    Jareth C. Wolfe
    Ioni Hunter
    Saskia Beckett-Doyle
    ...[+1 authors]...,
    Sue Cotterill
    Hongsheng Dai
    Andrew Harrison
    Nicolae Radu Zabet
    First Published March 30, 2022
  - GC content, but not nucleosome positioning, directly contributes to intron splicing efficiency in Paramecium
    Stefano Gnan
    Mélody Matelot
    Marion Weiman
    Olivier Arnaiz
    Frédéric Guérin
    Linda Sperling
    ...[+1 authors]...,
    Mireille Bétermier
    Claude Thermes
    Chun-Long Chen
    Sandra Duharcourt
    First Published March 9, 2022
  - Broad domains of histone marks in the highly compact Paramecium macronuclear genome
    Franziska Drews
    Abdulrahman Salhab
    Sivarajan Karunanithi
    Miriam Cheaib
    Martin Jung
    First Published March 9, 2022
Methods
- - Sequencing of individual barcoded cDNAs using Pacific Biosciences and Oxford Nanopore Technologies reveals platform-specific error patterns
    Alla Mikheenko
    Andrey D. Prjibelski
    Anoushka Joglekar
    Hagen U. Tilgner
    First Published March 17, 2022
  - Pan-human consensus genome significantly improves the accuracy of RNA-seq analyses
    Benjamin Kaminow
    Sara Ballouz
    Jesse Gillis
    Alexander Dobin
    First Published March 7, 2022
  - Identification of phenotype-specific networks from paired gene expression–cell shape imaging data
    Charlie George Barker
    Eirini Petsalaki
    Girolamo Giudice
    Julia Sero
    Emmanuel Nsa Ekpenyong
    First Published February 23, 2022
  - A framework to score the effects of structural variants in health and disease
    Philip Kleinert
    Martin Kircher
    First Published February 23, 2022
  - An association test of the spatial distribution of rare missense variants within protein structures identifies Alzheimer's disease–related patterns
    Bowen Jin
    John A. Capra
    Penelope Benchek
    Nicholas Wheeler
    Adam C. Naj
    Kara L. Hamilton-Nelson John J. Farrell Yuk Yee Leung Brian Kunkle Badri Vadarajan Gerard D. Schellenberg Richard Mayeux Li-San Wang Lindsay A. Farrer Margaret A. Pericak-Vance
    ...[+10 authors]...,
    Eden R. Martin
    Jonathan L. Haines
    Dana C. Crawford
    William S. Bush
    First Published February 24, 2022
  - Variations in antibody repertoires correlate with vaccine responses
    Yana Safonova
    Sung Bong Shin
    Luke Kramer
    James Reecy
    Corey T. Watson
    First Published March 31, 2022
Erratum
- - Erratum: Genome biology of the darkedged splitfin, Girardinichthys multiradiatus, and the evolution of sex chromosomes and placentation
    First Published April 8, 2022

Table of Contents

Volume 32, Issue 4 | April 2022

In memoriam

Haig H. Kazazian, Jr. (1937–2022)

Commentary

Implications of the first complete human genome assembly

Perspectives

Short arms of human acrocentric chromosomes and the completion of the human genome sequence

The genetics and epigenetics of satellite centromeres

Research

Chromosome-specific telomere lengths and the minimal functional telomere revealed by nanopore sequencing

MYC overexpression leads to increased chromatin interactions at super-enhancers and MYC binding sites

Somatic structural variant formation is guided by and influences genome architecture

A hidden layer of structural variation in transposable elements reveals potential genetic modifiers in human disease-risk loci

Accumulation and ineffective silencing of transposable elements on an avian W Chromosome

The role of insulators and transcription in 3D chromatin organization of flies

GC content, but not nucleosome positioning, directly contributes to intron splicing efficiency in Paramecium

Broad domains of histone marks in the highly compact Paramecium macronuclear genome

Methods

Sequencing of individual barcoded cDNAs using Pacific Biosciences and Oxford Nanopore Technologies reveals platform-specific error patterns

Pan-human consensus genome significantly improves the accuracy of RNA-seq analyses

Identification of phenotype-specific networks from paired gene expression–cell shape imaging data

A framework to score the effects of structural variants in health and disease

An association test of the spatial distribution of rare missense variants within protein structures identifies Alzheimer's disease–related patterns

Variations in antibody repertoires correlate with vaccine responses

Erratum

Erratum: Genome biology of the darkedged splitfin, Girardinichthys multiradiatus, and the evolution of sex chromosomes and placentation

Table of Contents

Volume 32, Issue 4 | April 2022

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In memoriam

Commentary

Perspectives

Research

Methods

Erratum