Volume 32, Issue 1 | January 2022

Review
- - Advancing genomic technologies and clinical awareness accelerates discovery of disease-associated tandem repeat sequences
    Terence Gall-Duncan
    Nozomu Sato
    Ryan K.C. Yuen
    Christopher E. Pearson
    First Published December 29, 2021
Research
- - Spatial organization of chromosomes leads to heterogeneous chromatin motion and drives the liquid- or gel-like dynamical behavior of chromatin
    Hossein Salari
    Marco Di Stefano
    Daniel Jost
    First Published December 28, 2021
  - Low-frequency somatic copy number alterations in normal human lymphocytes revealed by large-scale single-cell whole-genome profiling
    Lu Liu
    He Chen
    Cheng Sun
    Jianyun Zhang
    Juncheng Wang
    Meijie Du Jie Li Lin Di Jie Shen Shuang Geng Yuhong Pang Yingying Luo Chen Wu
    ...[+8 authors]...,
    Yusi Fu
    Zhe Zheng
    Jianbin Wang
    Yanyi Huang
    First Published December 28, 2021
  - Diverse tumorigenic consequences of human papillomavirus integration in primary oropharyngeal cancers
    Symer David E.
    Akagi Keiko
    Geiger Heather M.
    Song Yang
    Li Gaiyun
    Emde Anne-Katrin Xiao Weihong Jiang Bo Corvelo André Toussaint Nora C. Li Jingfeng Agrawal Amit Ozer Enver El-Naggar Adel K. Du Zoe Shewale Jitesh B. Stache-Crain Birgit
    ...[+12 authors]...,
    Zucker Mark
    Robine Nicolas
    Coombes Kevin R.
    Gillison Maura L.
    First Published December 13, 2021
  - Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states
    Oliver J. Ziff
    Benjamin E. Clarke
    Doaa M. Taha
    Hamish Crerar
    Nicholas M. Luscombe
    Rickie Patani
    First Published December 28, 2021
  - Genomic environments scale the activities of diverse core promoters
    Clarice K.Y. Hong
    Barak A. Cohen
    First Published December 27, 2021
  - Cell type–specific analysis by single-cell profiling identifies a stable mammalian tRNA–mRNA interface and increased translation efficiency in neurons
    William Gao
    Carlos J. Gallardo-Dodd
    Claudia Kutter
    First Published December 2, 2021
  - Mediator dynamics during heat shock in budding yeast
    Debasish Sarkar
    Z. Iris Zhu
    Elizabeth R. Knoll
    Emily Paul
    David Landsman
    Randall H. Morse
    First Published November 16, 2021
Methods
- - De novo individualized disease modules reveal the synthetic penetrance of genes and inform personalized treatment regimens
    Taylor M. Weiskittel
    Choong Y. Ung
    Cristina Correia
    Cheng Zhang
    Hu Li
    First Published December 7, 2021
  - A full-proteome, interaction-specific characterization of mutational hotspots across human cancers
    Siwei Chen
    Yuan Liu
    Yingying Zhang
    Shayne D. Wierbowski
    Steven M. Lipkin
    Xiaomu Wei
    Haiyuan Yu
    First Published December 28, 2021
  - Profiling chromatin accessibility in formalin-fixed paraffin-embedded samples
    Hua Zhang
    Vamsi Krishna Polavarapu
    Pengwei Xing
    Miao Zhao
    Lucy Mathot
    Linxuan Zhao
    ...[+1 authors]...,
    Gabriela Rosen
    Fredrik J. Swartling
    Tobias Sjöblom
    Xingqi Chen
    First Published July 14, 2021
  - Comprehensive determination of transcription start sites derived from all RNA polymerases using ReCappable-seq
    Bo Yan
    George Tzertzinis
    Ira Schildkraut
    Laurence Ettwiller
    First Published November 23, 2021
Resources
- - RefSeq Functional Elements as experimentally assayed nongenic reference standards and functional interactions in human and mouse
    Farrell Catherine M.
    Goldfarb Tamara
    Rangwala Sanjida H.
    Astashyn Alexander
    Ermolaeva Olga D.
    Hem Vichet Katz Kenneth S. Kodali Vamsi K.
    ...[+3 authors]...,
    Ludwig Frank
    Wallin Craig L.
    Pruitt Kim D.
    Murphy Terence D.
    First Published December 7, 2021
  - Transposable element variants and their potential adaptive impact in urban populations of the malaria vector Anopheles coluzzii
    Carlos Vargas-Chavez
    Neil Michel Longo Pendy
    Sandrine E. Nsango
    Laura Aguilera
    Diego Ayala
    Josefa González
    First Published December 29, 2021
  - Long-read assembly and comparative evidence-based reanalysis of Cryptosporidium genome sequences reveal expanded transporter repertoire and duplication of entire chromosome ends including subtelomeric regions
    Rodrigo P. Baptista
    Yiran Li
    Adam Sateriale
    Mandy J. Sanders
    Karen L. Brooks
    Alan Tracey Brendan R.E. Ansell Aaron R. Jex Garrett W. Cooper Ethan D. Smith Rui Xiao Jennifer E. Dumaine Peter Georgeson Bernard J. Pope
    ...[+9 authors]...,
    Matthew Berriman
    Boris Striepen
    James A. Cotton
    Jessica C. Kissinger
    First Published November 11, 2021

Table of Contents

Volume 32, Issue 1 | January 2022

Review

Advancing genomic technologies and clinical awareness accelerates discovery of disease-associated tandem repeat sequences

Research

Spatial organization of chromosomes leads to heterogeneous chromatin motion and drives the liquid- or gel-like dynamical behavior of chromatin

Low-frequency somatic copy number alterations in normal human lymphocytes revealed by large-scale single-cell whole-genome profiling

Diverse tumorigenic consequences of human papillomavirus integration in primary oropharyngeal cancers

Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states

Genomic environments scale the activities of diverse core promoters

Cell type–specific analysis by single-cell profiling identifies a stable mammalian tRNA–mRNA interface and increased translation efficiency in neurons

Mediator dynamics during heat shock in budding yeast

Methods

De novo individualized disease modules reveal the synthetic penetrance of genes and inform personalized treatment regimens

A full-proteome, interaction-specific characterization of mutational hotspots across human cancers

Profiling chromatin accessibility in formalin-fixed paraffin-embedded samples

Comprehensive determination of transcription start sites derived from all RNA polymerases using ReCappable-seq

Resources

RefSeq Functional Elements as experimentally assayed nongenic reference standards and functional interactions in human and mouse

Transposable element variants and their potential adaptive impact in urban populations of the malaria vector Anopheles coluzzii

Long-read assembly and comparative evidence-based reanalysis of Cryptosporidium genome sequences reveal expanded transporter repertoire and duplication of entire chromosome ends including subtelomeric regions

Table of Contents

Volume 32, Issue 1 | January 2022

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Review

Research

Methods

Resources