Volume 31, Issue 9 | September 2021

Research
- - Differences in the number of de novo mutations between individuals are due to small family-specific effects and stochasticity
    Jakob M. Goldmann
    Juliet E. Hampstead
    Wendy S.W. Wong
    Amy B. Wilfert
    Tychele N. Turner
    Marianne A. Jonker Raphael Bernier Martijn A. Huynen
    ...[+3 authors]...,
    Evan E. Eichler
    Joris A. Veltman
    George L. Maxwell
    Christian Gilissen
    First Published July 23, 2021
  - Parental methylome reprogramming in human uniparental blastocysts reveals germline memory transition
    Jiawei Xu
    Yimin Shu
    Guidong Yao
    Yu Zhang
    Wenbin Niu
    Yile Zhang Xueshan Ma Haixia Jin Fuli Zhang Senlin Shi Yang Wang Wenyan Song Shanjun Dai Luyao Cheng
    ...[+9 authors]...,
    Xiangyang Zhang
    Wei Xie
    Aaron J. Hsueh
    Yingpu Sun
    First Published July 30, 2021
  - Transposable elements and their KZFP controllers are drivers of transcriptional innovation in the developing human brain
    Christopher J. Playfoot
    Julien Duc
    Shaoline Sheppard
    Sagane Dind
    Alexandre Coudray
    First Published August 16, 2021
  - Ligand-induced native G-quadruplex stabilization impairs transcription initiation
    Conghui Li
    Honghong Wang
    Zhinang Yin
    Pingping Fang
    Ruijing Xiao
    Ying Xiang Wen Wang
    ...[+2 authors]...,
    Qiuzi Li
    Beili Huang
    Jian Huang
    Kaiwei Liang
    First Published August 16, 2021
  - Genome-wide variability in recombination activity is associated with meiotic chromatin organization
    Xiaofan Jin
    Geoff Fudenberg
    Katherine S. Pollard
    First Published July 23, 2021
  - The hourglass model of evolutionary conservation during embryogenesis extends to developmental enhancers with signatures of positive selection
    Jialin Liu
    Rebecca R. Viales
    Pierre Khoueiry
    James P. Reddington
    Charles Girardot
    First Published July 15, 2021
  - Temperature dependence of spontaneous mutation rates
    Ann-Marie Waldvogel
    Markus Pfenninger
    First Published July 23, 2021
  - Single worm transcriptomics identifies a developmental core network of oscillating genes with deep conservation across nematodes
    Shuai Sun
    Christian Rödelsperger
    Ralf J. Sommer
    First Published July 22, 2021
  - Mutability of mononucleotide repeats, not oxidative stress, explains the discrepancy between laboratory-accumulated mutations and the natural allele-frequency spectrum in C. elegans
    Moein Rajaei
    Ayush Shekhar Saxena
    Lindsay M. Johnson
    Michael C. Snyder
    Timothy A. Crombie
    First Published August 17, 2021
  - Crossover-active regions of the wheat genome are distinguished by DMC1, the chromosome axis, H3K27me3, and signatures of adaptation
    Andrew J. Tock
    Daniel M. Holland
    Wei Jiang
    Kim Osman
    Eugenio Sanchez-Moran
    James D. Higgins
    ...[+1 authors]...,
    Keith J. Edwards
    Cristobal Uauy
    F. Chris H. Franklin
    Ian R. Henderson
    First Published August 23, 2021
Methods
- - Inferring genes that escape X-Chromosome inactivation reveals important contribution of variable escape genes to sex-biased diseases
    Renan Sauteraud
    Jill M. Stahl
    Jesica James
    Marisa Englebright
    Fang Chen
    First Published August 23, 2021
  - Sequence-based correction of barcode bias in massively parallel reporter assays
    Dongwon Lee
    Ashish Kapoor
    Changhee Lee
    Michael Mudgett
    Michael A. Beer
    First Published July 20, 2021
  - A universal framework for detecting cis-regulatory diversity in DNA regions
    Anushua Biswas
    Leelavati Narlikar
    First Published July 19, 2021
Resources
- - A ChIP-exo screen of 887 Protein Capture Reagents Program transcription factor antibodies in human cells
    William K.M. Lai
    Luca Mariani
    Gerson Rothschild
    Edwin R. Smith
    Bryan J. Venters
    Thomas R. Blanda Prashant K. Kuntala Kylie Bocklund Joshua Mairose Sarah N. Dweikat Katelyn Mistretta Matthew J. Rossi Daniela James James T. Anderson Sabrina K. Phanor Wanwei Zhang Zibo Zhao Avani P. Shah Katherine Novitzky Eileen McAnarney Michael-C. Keogh
    ...[+16 authors]...,
    Ali Shilatifard
    Uttiya Basu
    Martha L. Bulyk
    B. Franklin Pugh
    First Published August 23, 2021
  - Global patterns of enhancer activity during sea urchin embryogenesis assessed by eRNA profiling
    Jian Ming Khor
    Jennifer Guerrero-Santoro
    William Douglas
    Charles A. Ettensohn
    First Published July 30, 2021

Table of Contents

Volume 31, Issue 9 | September 2021

Research

Differences in the number of de novo mutations between individuals are due to small family-specific effects and stochasticity

Parental methylome reprogramming in human uniparental blastocysts reveals germline memory transition

Transposable elements and their KZFP controllers are drivers of transcriptional innovation in the developing human brain

Ligand-induced native G-quadruplex stabilization impairs transcription initiation

Genome-wide variability in recombination activity is associated with meiotic chromatin organization

The hourglass model of evolutionary conservation during embryogenesis extends to developmental enhancers with signatures of positive selection

Temperature dependence of spontaneous mutation rates

Single worm transcriptomics identifies a developmental core network of oscillating genes with deep conservation across nematodes

Mutability of mononucleotide repeats, not oxidative stress, explains the discrepancy between laboratory-accumulated mutations and the natural allele-frequency spectrum in C. elegans

Crossover-active regions of the wheat genome are distinguished by DMC1, the chromosome axis, H3K27me3, and signatures of adaptation

Methods

Inferring genes that escape X-Chromosome inactivation reveals important contribution of variable escape genes to sex-biased diseases

Sequence-based correction of barcode bias in massively parallel reporter assays

A universal framework for detecting cis-regulatory diversity in DNA regions

Resources

A ChIP-exo screen of 887 Protein Capture Reagents Program transcription factor antibodies in human cells

Global patterns of enhancer activity during sea urchin embryogenesis assessed by eRNA profiling

Table of Contents

Volume 31, Issue 9 | September 2021

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Research

Methods

Resources