Volume 30, Issue 12 | December 2020

Research
- - Complex mosaic structural variations in human fetal brains
    Shobana Sekar
    Livia Tomasini
    Christos Proukakis
    Taejeong Bae
    Logan Manlove
    Yeongjun Jang Soraya Scuderi Bo Zhou Maria Kalyva Anahita Amiri Jessica Mariani
    ...[+6 authors]...,
    Fritz J. Sedlazeck
    Alexander E. Urban
    Flora M. Vaccarino
    Alexej Abyzov
    First Published October 29, 2020
  - Widespread intron retention impairs protein homeostasis in C9orf72 ALS brains
    Qingqing Wang
    Erin G. Conlon
    James L. Manley
    Donald C. Rio
    First Published October 14, 2020
  - Sequence analysis in Bos taurus reveals pervasiveness of X–Y arms races in mammalian lineages
    Jennifer F. Hughes
    Helen Skaletsky
    Tatyana Pyntikova
    Natalia Koutseva
    Terje Raudsepp
    Laura G. Brown Daniel W. Bellott Ting-Jan Cho Shannon Dugan-Rocha Ziad Khan Colin Kremitzki Catrina Fronick Tina A. Graves-Lindsay Lucinda Fulton Wesley C. Warren Richard K. Wilson Elaine Owens James E. Womack William J. Murphy Donna M. Muzny
    ...[+15 authors]...,
    Kim C. Worley
    Bhanu P. Chowdhary
    Richard A. Gibbs
    David C. Page
    First Published November 18, 2020
  - Tissue-specific patterns of regulatory changes underlying gene expression differences among Ficedula flycatchers and their naturally occurring F1 hybrids
    Carina F. Mugal
    Mi Wang
    Niclas Backström
    David Wheatcroft
    Murielle Ålund
    Marie Sémon
    ...[+1 authors]...,
    S. Eryn McFarlane
    Ludovic Dutoit
    Anna Qvarnström
    Hans Ellegren
    First Published November 3, 2020
  - Loss of histone H3.3 results in DNA replication defects and altered origin dynamics in C. elegans
    Maude Strobino
    Joanna M. Wenda
    Laura Padayachy
    Florian A. Steiner
    First Published November 10, 2020
  - Distinctive regulatory architectures of germline-active and somatic genes in C. elegans
    Jacques Serizay
    Yan Dong
    Jürgen Jänes
    Michael Chesney
    Chiara Cerrato
    First Published October 22, 2020
  - Global regulatory features of alternative splicing across tissues and within the nervous system of C. elegans
    Bina Koterniak
    Pallavi P. Pilaka
    Xicotencatl Gracida
    Lisa-Marie Schneider
    Iva Pritišanac
    First Published October 30, 2020
  - Sequencing identifies multiple early introductions of SARS-CoV-2 to the New York City region
    Matthew T. Maurano
    Sitharam Ramaswami
    Paul Zappile
    Dacia Dimartino
    Ludovic Boytard
    André M. Ribeiro-dos-Santos Nicholas A. Vulpescu Gael Westby Guomiao Shen Xiaojun Feng Megan S. Hogan Manon Ragonnet-Cronin Lily Geidelberg Christian Marier Peter Meyn Yutong Zhang John Cadley Raquel Ordoñez Raven Luther Emily Huang Emily Guzman Carolina Arguelles-Grande Kimon V. Argyropoulos Margaret Black Antonio Serrano Melissa E. Call Min Jae Kim Brendan Belovarac Tatyana Gindin Andrew Lytle Jared Pinnell Theodore Vougiouklakis John Chen Lawrence H. Lin Amy Rapkiewicz Vanessa Raabe Marie I. Samanovic George Jour Iman Osman Maria Aguero-Rosenfeld Mark J. Mulligan
    ...[+36 authors]...,
    Erik M. Volz
    Paolo Cotzia
    Matija Snuderl
    Adriana Heguy
    First Published October 22, 2020
Methods
- - Ultrafast and scalable variant annotation and prioritization with big functional genomics data
    Dandan Huang
    Xianfu Yi
    Yao Zhou
    Hongcheng Yao
    Hang Xu
    Jianhua Wang Shijie Zhang Wenyan Nong Panwen Wang Lei Shi Chenghao Xuan Miaoxin Li Junwen Wang Weidong Li
    ...[+9 authors]...,
    Hoi Shan Kwan
    Pak Chung Sham
    Kai Wang
    Mulin Jun Li
    First Published October 15, 2020
  - Identifying chromosomal subpopulations based on their recombination histories advances the study of the genetic basis of phenotypic traits
    Carlos Ruiz-Arenas
    Alejandro Cáceres
    Marcos López
    Dolors Pelegrí-Sisó
    Josefa González
    First Published November 17, 2020
  - Cross-species analysis of enhancer logic using deep learning
    Liesbeth Minnoye
    Ibrahim Ihsan Taskiran
    David Mauduit
    Maurizio Fazio
    Linde Van Aerschot
    Gert Hulselmans Valerie Christiaens Samira Makhzami Monika Seltenhammer Panagiotis Karras Aline Primot Edouard Cadieu Ellen van Rooijen Jean-Christophe Marine Giorgia Egidy
    ...[+10 authors]...,
    Ghanem-Elias Ghanem
    Leonard Zon
    Jasper Wouters
    Stein Aerts
    First Published July 30, 2020
  - Predicting unrecognized enhancer-mediated genome topology by an ensemble machine learning model
    Li Tang
    Matthew C. Hill
    Jun Wang
    Jianxin Wang
    James F. Martin
    First Published November 12, 2020
  - Pooled protein tagging, cellular imaging, and in situ sequencing for monitoring drug action in real time
    Andreas Reicher
    Anna Koren
    Stefan Kubicek
    First Published November 17, 2020
Corrigendum
- - Corrigendum: Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians
    First Published December 1, 2020
Reviewer Index
- - Reviewer Index, Volume 30, 2020
    First Published December 1, 2020

Table of Contents

Volume 30, Issue 12 | December 2020

Research

Complex mosaic structural variations in human fetal brains

Widespread intron retention impairs protein homeostasis in C9orf72 ALS brains

Sequence analysis in Bos taurus reveals pervasiveness of X–Y arms races in mammalian lineages

Tissue-specific patterns of regulatory changes underlying gene expression differences among Ficedula flycatchers and their naturally occurring F1 hybrids

Loss of histone H3.3 results in DNA replication defects and altered origin dynamics in C. elegans

Distinctive regulatory architectures of germline-active and somatic genes in C. elegans

Global regulatory features of alternative splicing across tissues and within the nervous system of C. elegans

Sequencing identifies multiple early introductions of SARS-CoV-2 to the New York City region

Methods

Ultrafast and scalable variant annotation and prioritization with big functional genomics data

Identifying chromosomal subpopulations based on their recombination histories advances the study of the genetic basis of phenotypic traits

Cross-species analysis of enhancer logic using deep learning

Predicting unrecognized enhancer-mediated genome topology by an ensemble machine learning model

Pooled protein tagging, cellular imaging, and in situ sequencing for monitoring drug action in real time

Corrigendum

Corrigendum: Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians

Reviewer Index

Reviewer Index, Volume 30, 2020

Table of Contents

Volume 30, Issue 12 | December 2020

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Research

Methods

Corrigendum

Reviewer Index