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Galaxy: A platform for interactive large-scale genome analysis

    • 1 Center for Comparative Genomics and Bioinformatics, Huck Institutes for Life Sciences, Penn State University, University Park, Pennsylvania 16802, USA
    • 2 National Human Genome Research Institute, Bethesda, Maryland 20892, USA
    • 3 Department of Computer Science and Engineering, University of California at Santa Cruz, Santa Cruz, California 95064, USA
Published September 16, 2005. Vol 15 Issue 10, pp. 1451-1455. https://doi.org/10.1101/gr.4086505
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cover of Genome Research Vol 36 Issue 4
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April 2026, Vol. 36, No. 4
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Abstract

Accessing and analyzing the exponentially expanding genomic sequence and functional data pose a challenge for biomedical researchers. Here we describe an interactive system, Galaxy, that combines the power of existing genome annotation databases with a simple Web portal to enable users to search remote resources, combine data from independent queries, and visualize the results. The heart of Galaxy is a flexible history system that stores the queries from each user; performs operations such as intersections, unions, and subtractions; and links to other computational tools. Galaxy can be accessed at http://g2.bx.psu.edu.

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