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Research

Enhanced detection of RNA modifications and read mapping with high-accuracy nanopore RNA basecalling models

  • First Published September 13, 2024
Research

Long-read DNA and cDNA sequencing identify cancer-predisposing deep intronic variation in tumor-suppressor genes

  • First Published September 13, 2024
Resource

Comprehensive identification of genomic and environmental determinants of phenotypic plasticity in maize

  • First Published September 13, 2024
Research

SF3B1 mutations" > Long-read transcriptome sequencing of CLL and MDS patients uncovers molecular effects of SF3B1 mutations

  • First Published September 13, 2024
Method

A novel approach for in vivo DNA footprinting using short double-stranded cell-free DNA from plasma

  • First Published September 13, 2024
Research

Evidence for compensatory evolution within pleiotropic regulatory elements

  • First Published September 10, 2024
Method

Genetic complexity of killer-cell immunoglobulin-like receptor genes in human pangenome assemblies

  • First Published September 9, 2024
Research

Differences in activity and stability drive transposable element variation in tropical and temperate maize

  • First Published September 9, 2024
Method

Privacy-preserving biological age prediction over federated human methylation data using fully homomorphic encryption

  • First Published September 5, 2024
Method

A Bayesian framework for inferring dynamic intercellular interactions from time-series single-cell data

  • First Published September 5, 2024
Method

Protein domain embeddings for fast and accurate similarity search

  • First Published September 5, 2024
Method

Spatial Cellular Networks from omics data with SpaCeNet

  • First Published September 4, 2024
Method

A best-match approach for gene set analyses in embedding spaces

  • First Published September 4, 2024
Method

Matrix sketching framework for linear mixed models in association studies

  • First Published September 4, 2024
Research

Genome-wide patterns of selection–drift variation strongly associate with organismal traits across the green plant lineage

  • First Published August 29, 2024
Method

A scalable adaptive quadratic kernel method for interpretable epistasis analysis in complex traits

  • First Published August 29, 2024
Resource

Allele-specific transcription factor binding across human brain regions offers mechanistic insight into eQTLs

  • First Published August 16, 2024
Research

Widespread natural selection on metabolite levels in humans

  • First Published August 16, 2024
Research

Colibactin leads to a bacteria-specific mutation pattern and self-inflicted DNA damage

  • First Published August 16, 2024
Resource

Visualization and analysis of medically relevant tandem repeats in nanopore sequencing of control cohorts with pathSTR

  • First Published August 15, 2024
Method

Benchmarking bulk and single-cell variant-calling approaches on Chromium scRNA-seq and scATAC-seq libraries

  • First Published August 15, 2024
Method

A fast and adaptive detection framework for genome-wide chromatin loop mapping from Hi-C data

  • First Published August 13, 2024
Method

Pangenome-spanning epistasis and coselection analysis via de Bruijn graphs

  • First Published August 12, 2024
Method

A gene regulatory network–aware graph learning method for cell identity annotation in single-cell RNA-seq data

  • First Published August 12, 2024
Method

Bayesian inference of sample-specific coexpression networks

  • First Published August 12, 2024
Research

The Chinese longsnout catfish genome provides novel insights into the feeding preference and corresponding metabolic strategy of carnivores

  • First Published August 9, 2024
Method

Reconstructing extrachromosomal DNA structural heterogeneity from long-read sequencing data using Decoil

  • First Published August 7, 2024
Method

Secure discovery of genetic relatives across large-scale and distributed genomic data sets

  • First Published August 7, 2024
Research

TBC1D3 gene family in humans" > Independent expansion, selection, and hypervariability of the TBC1D3 gene family in humans

  • First Published August 6, 2024
Method

Accurate assembly of circular RNAs with TERRACE

  • First Published July 26, 2024
Method

Parameter-efficient fine-tuning on large protein language models improves signal peptide prediction

  • First Published July 26, 2024
Method

Reference-informed prediction of alternative splicing and splicing-altering mutations from sequences

  • First Published July 26, 2024
Corrigendum

Corrigendum: Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere

  • First Published July 23, 2024
Resource

Global compositional and functional states of the human gut microbiome in health and disease

  • First Published July 22, 2024
Method

Scalable summary-statistics-based heritability estimation method with individual genotype level accuracy

  • First Published July 22, 2024
Method

Graph-based self-supervised learning for repeat detection in metagenomic assembly

  • First Published July 19, 2024
Method

High-fidelity, large-scale targeted profiling of microsatellites

  • First Published July 16, 2024
Method

Haplotype-aware sequence alignment to pangenome graphs

  • First Published July 16, 2024
Research

6A RNA modifications in the hippocampus" > Single-cell discovery of m6A RNA modifications in the hippocampus

  • First Published July 15, 2024
Resource

DEAD box RNA helicases are pervasive protein kinase interactors and activators

  • First Published July 10, 2024
Method

Accurate allocation of multimapped reads enables regulatory element analysis at repeats

  • First Published July 10, 2024
Method

Accurate estimation of pathway activity in single cells for clustering and differential analysis

  • First Published July 9, 2024
Method

CoRAL accurately resolves extrachromosomal DNA genome structures with long-read sequencing

  • First Published July 9, 2024
Research

Single-cell analysis reveals transcriptional dynamics in healthy primary parathyroid tissue

  • First Published July 8, 2024
Research

Cryptosporidium parvum reveals the emergence of an outbreak-associated population in Europe and its spread to the United States" > Comparative genomics of Cryptosporidium parvum reveals the emergence of an outbreak-associated population in Europe and its spread to the United States

  • First Published July 8, 2024
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