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In memoriam

Jim Watson (1928–2025): a genomics visionary

  • First Published July 23, 2026
Method

Accurate estimation of intraspecific microbial gene content variation in metagenomic data with MIDAS v3 and StrainPGC

  • First Published April 10, 2025
Resource

Allele-specific transcription factor binding across human brain regions offers mechanistic insight into eQTLs

  • First Published August 16, 2024
Method

cis-regulatory elements" > Probabilistic association of differentially expressed genes with cis-regulatory elements

  • First Published April 17, 2024
Research

Characterization of human transcription factor function and patterns of gene regulation in HepG2 cells

  • First Published October 18, 2023
In memoriam

C. Thomas Caskey (1938–2022)

  • First Published February 17, 2022
In memoriam

Deborah A. Nickerson (1954 –2021)

  • First Published January 24, 2022
Research

Genome-wide strand asymmetry in massively parallel reporter activity favors genic strands

  • First Published April 20, 2021
Research

Dissecting the regulatory activity and sequence content of loci with exceptional numbers of transcription factor associations

  • First Published July 2, 2020
Resource

Dynamics of microRNA expression during mouse prenatal development

  • First Published October 23, 2019
Research

Sequence determinants of polyadenylation-mediated regulation

  • First Published September 17, 2019
Method

A new approach for rare variation collapsing on functional protein domains implicates specific genic regions in ALS

  • First Published April 2, 2019
Research

Systematic interrogation of human promoters

  • First Published January 8, 2019
Resource

A genome-wide interactome of DNA-associated proteins in the human liver

  • First Published October 11, 2017
Corrigendum

Corrigendum: Large-scale mapping of gene regulatory logic reveals context-dependent repression by transcriptional activators

  • First Published March 1, 2017
Research

Large-scale mapping of gene regulatory logic reveals context-dependent repression by transcriptional activators

  • First Published December 13, 2016
Research

Promoter-distal RNA polymerase II binding discriminates active from inactive CCAAT/ enhancer-binding protein beta binding sites

  • First Published October 20, 2015
Research

Noise in gene expression is coupled to growth rate

  • First Published September 9, 2015
Method

CETCh-seq: CRISPR epitope tagging ChIP-seq of DNA-binding proteins

  • First Published September 9, 2015
Corrigendum

Corrigendum: Unraveling determinants of transcription factor binding outside the core binding site

  • First Published September 1, 2015
Research

Core promoter sequence in yeast is a major determinant of expression level

  • First Published May 12, 2015
Method

Unraveling determinants of transcription factor binding outside the core binding site

  • First Published March 11, 2015
Research

Molecular dissection of the genetic mechanisms that underlie expression conservation in orthologous yeast ribosomal promoters

  • First Published October 7, 2014
Method

Probing the effect of promoters on noise in gene expression using thousands of designed sequences

  • First Published July 16, 2014
Method

From single-cell to cell-pool transcriptomes: Stochasticity in gene expression and RNA splicing

  • First Published December 3, 2013
Resource

Integrating and mining the chromatin landscape of cell-type specificity using self-organizing maps

  • First Published October 29, 2013
Resource

Inferring gene expression from ribosomal promoter sequences, a crowdsourcing approach

  • First Published August 15, 2013
Research

Two DNA-encoded strategies for increasing expression with opposing effects on promoter dynamics and transcriptional noise

  • First Published February 12, 2013
Resource

Dynamic DNA methylation across diverse human cell lines and tissues

  • First Published January 16, 2013
Research

Widespread plasticity in CTCF occupancy linked to DNA methylation

  • First Published September 5, 2012
Resource

ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia

  • First Published September 5, 2012
Resource

Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factors

  • First Published September 5, 2012
Research

Effects of sequence variation on differential allelic transcription factor occupancy and gene expression

  • First Published February 2, 2012
Method

Transposase mediated construction of RNA-seq libraries

  • First Published November 29, 2011
Research

Compensation for differences in gene copy number among yeast ribosomal proteins is encoded within their promoters

  • First Published October 18, 2011
Research

DNA methylation profiling reveals novel biomarkers and important roles for DNA methyltransferases in prostate cancer

  • First Published April 26, 2011
Research

C. elegans" > High nucleosome occupancy is encoded at X-linked gene promoters in C. elegans

  • First Published December 22, 2010
Research

Overlapping codes within protein-coding sequences

  • First Published September 14, 2010
Research

p53 binds preferentially to genomic regions with high DNA-encoded nucleosome occupancy

  • First Published August 17, 2010
Research

Sequence features that drive human promoter function and tissue specificity

  • First Published May 25, 2010
Letter

Evolutionary constraint facilitates interpretation of genetic variation in resequenced human genomes

  • First Published January 12, 2010
Article

Genomic determination of the glucocorticoid response reveals unexpected mechanisms of gene regulation

  • First Published October 2, 2009
Resource

The completion of the Mammalian Gene Collection (MGC)

  • First Published September 18, 2009
Methods

Incorporating nucleosomes into thermodynamic models of transcription regulation

  • First Published May 18, 2009
Letter

Signals of recent positive selection in a worldwide sample of human populations

  • First Published March 23, 2009
LETTER

Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets

  • First Published February 7, 2008
Methods

cis-regulatory motifs in human core promoters" > Systematic functional characterization of cis-regulatory motifs in human core promoters

  • First Published February 6, 2008
ARTICLE

Integrated analysis of experimental data sets reveals many novel promoters in 1% of the human genome

  • First Published June 13, 2007
ARTICLE

Prominent use of distal 5′ transcription start sites and discovery of a large number of additional exons in ENCODE regions

  • First Published June 13, 2007
LETTER

Transcription factor binding and modified histones in human bidirectional promoters

  • First Published June 13, 2007
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