A Physical Map of the Leishmania majorFriedlin Genome

Alasdair C. Ivens; Sharon M. Lewis; Azadeh Bagherzadeh; Linglan Zhang; Ho M. Chan; Deborah F. Smith

doi:10.1101/gr.8.2.135

A Physical Map of the Leishmania majorFriedlin Genome

- Department of Biochemistry, Imperial College of Science, Technology and Medicine, London SW7 2AZ, UK

Published February 1, 1998. Vol 8 Issue 2, pp. 135-145. https://doi.org/10.1101/gr.8.2.135

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Abstract

An extensive physical map of the Leishmania majorFriedlin genome has been assembled by the combination of fingerprint analysis of a shuttle vector cosmid library and probe hybridization. The integrated data obtained for 9004 fingerprinted clones and 974 probes have placed 91.2% of the 33.58-Mb genome into contigs representing each of the 36 chromosomes. This first-generation map has already provided a suitable framework for both high-throughput DNA sequencing and functional studies of the L. major parasite.

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