Volume 27, Issue 4 | April 2017

Research
- - Pan-cancer analysis distinguishes transcriptional changes of aneuploidy from proliferation
    Christopher Buccitelli
    Lorena Salgueiro
    Konstantina Rowald
    Rocio Sotillo
    Balca R. Mardin
    First Published March 20, 2017
  - One thousand somatic SNVs per skin fibroblast cell set baseline of mosaic mutational load with patterns that suggest proliferative origin
    Alexej Abyzov
    Livia Tomasini
    Bo Zhou
    Nikolaos Vasmatzis
    Gianfilippo Coppola
    Mariangela Amenduni Reenal Pattni Michael Wilson
    ...[+3 authors]...,
    Mark Gerstein
    Sherman Weissman
    Alexander E. Urban
    Flora M. Vaccarino
    First Published February 24, 2017
  - Integrated genomic analyses reveal frequent TERT aberrations in acral melanoma
    Winnie S. Liang
    William Hendricks
    Jeffrey Kiefer
    Jessica Schmidt
    Shobana Sekar
    John Carpten David W. Craig Jonathan Adkins Lori Cuyugan Zarko Manojlovic Rebecca F. Halperin Adrienne Helland Sara Nasser Christophe Legendre Laurence H. Hurley Karthigayini Sivaprakasam Douglas B. Johnson Holly Crandall Klaus J. Busam Victoria Zismann Valerie Deluca Jeeyun Lee
    ...[+17 authors]...,
    Aleksandar Sekulic
    Charlotte E. Ariyan
    Jeffrey Sosman
    Jeffrey Trent
    First Published April 3, 2017
  - Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells
    Yi Cai
    Hsing-Chen Tsai
    Ray-Whay Chiu Yen
    Yang W. Zhang
    Xiangqian Kong
    First Published February 23, 2017
  - Time-dependent genetic effects on gene expression implicate aging processes
    Julien Bryois
    Alfonso Buil
    Pedro G. Ferreira
    Nikolaos I. Panousis
    Andrew A. Brown
    Ana Viñuela Alexandra Planchon
    ...[+2 authors]...,
    Deborah Bielser
    Kerrin Small
    Tim Spector
    Emmanouil T. Dermitzakis
    First Published March 16, 2017
  - Distal CpG islands can serve as alternative promoters to transcribe genes with silenced proximal promoters
    Shrutii Sarda
    Avinash Das
    Charles Vinson
    Sridhar Hannenhalli
    First Published February 21, 2017
  - Transcriptome analyses of rhesus monkey preimplantation embryos reveal a reduced capacity for DNA double-strand break repair in primate oocytes and early embryos
    Xinyi Wang
    Denghui Liu
    Dajian He
    Shengbao Suo
    Xian Xia
    First Published February 21, 2017
  - In vivo binding of PRDM9 reveals interactions with noncanonical genomic sites
    Corinne Grey
    Julie A.J. Clément
    Jérôme Buard
    Benjamin Leblanc
    Ivo Gut
    First Published March 23, 2017
  - Regulation of nucleosome positioning by a CHD Type III chromatin remodeler and its relationship to developmental gene expression in Dictyostelium
    James L. Platt
    Nicholas A. Kent
    Alan R. Kimmel
    Adrian J. Harwood
    First Published March 22, 2017
  - Identical bacterial populations colonize premature infant gut, skin, and oral microbiomes and exhibit different in situ growth rates
    Matthew R. Olm
    Christopher T. Brown
    Brandon Brooks
    Brian Firek
    Robyn Baker
    David Burstein
    ...[+1 authors]...,
    Karina Soenjoyo
    Brian C. Thomas
    Michael Morowitz
    Jillian F. Banfield
    First Published January 10, 2017
Methods
- - Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations
    Jonathan S. Brammeld
    Mia Petljak
    Inigo Martincorena
    Steven P. Williams
    Luz Garcia Alonso
    Alba Dalmases Beatriz Bellosillo Carla Daniela Robles-Espinoza Stacey Price Syd Barthorpe Patrick Tarpey Constantine Alifrangis Graham Bignell Joana Vidal Jamie Young Lucy Stebbings Kathryn Beal Michael R. Stratton Julio Saez-Rodriguez
    ...[+14 authors]...,
    Mathew Garnett
    Clara Montagut
    Francesco Iorio
    Ultan McDermott
    First Published February 8, 2017
  - Microbial strain-level population structure and genetic diversity from metagenomes
    Duy Tin Truong
    Adrian Tett
    Edoardo Pasolli
    Curtis Huttenhower
    Nicola Segata
    First Published February 6, 2017
Resources
- - Large-scale analysis of branchpoint usage across species and cell lines
    Allison J. Taggart
    Chien-Ling Lin
    Barsha Shrestha
    Claire Heintzelman
    Seongwon Kim
    First Published January 24, 2017
  - Phenotypic diversity and genotypic flexibility of Burkholderia cenocepacia during long-term chronic infection of cystic fibrosis lungs
    Amy Huei-Yi Lee
    Stephane Flibotte
    Sunita Sinha
    Adrianna Paiero
    Rachel L. Ehrlich
    Sergey Balashov
    ...[+1 authors]...,
    Garth D. Ehrlich
    James E.A. Zlosnik
    Joshua Chang Mell
    Corey Nislow
    First Published March 21, 2017
Corrigendum
- - Corrigendum: A novel translational control mechanism involving RNA structures within coding sequences
    Jennifer Jungfleisch
    Danny D. Nedialkova
    Ivan Dotu
    Katherine E. Sloan
    Neus Martinez-Bosch
    Lukas Brüning Emanuele Raineri
    ...[+2 authors]...,
    Pilar Navarro
    Markus T. Bohnsack
    Sebastian A. Leidel
    Juana Díez
    First Published April 3, 2017

Table of Contents

Volume 27, Issue 4 | April 2017

Research

Pan-cancer analysis distinguishes transcriptional changes of aneuploidy from proliferation

One thousand somatic SNVs per skin fibroblast cell set baseline of mosaic mutational load with patterns that suggest proliferative origin

Integrated genomic analyses reveal frequent TERT aberrations in acral melanoma

Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells

Time-dependent genetic effects on gene expression implicate aging processes

Distal CpG islands can serve as alternative promoters to transcribe genes with silenced proximal promoters

Transcriptome analyses of rhesus monkey preimplantation embryos reveal a reduced capacity for DNA double-strand break repair in primate oocytes and early embryos

In vivo binding of PRDM9 reveals interactions with noncanonical genomic sites

Regulation of nucleosome positioning by a CHD Type III chromatin remodeler and its relationship to developmental gene expression in Dictyostelium

Identical bacterial populations colonize premature infant gut, skin, and oral microbiomes and exhibit different in situ growth rates

Methods

Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations

Microbial strain-level population structure and genetic diversity from metagenomes

Resources

Large-scale analysis of branchpoint usage across species and cell lines

Phenotypic diversity and genotypic flexibility of Burkholderia cenocepacia during long-term chronic infection of cystic fibrosis lungs

Corrigendum

Corrigendum: A novel translational control mechanism involving RNA structures within coding sequences

Table of Contents

Volume 27, Issue 4 | April 2017

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Research

Methods

Resources

Corrigendum