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Cover A cartoon depicting a boxer punching a hole into the DNA double strand using his Cas9/guide RNA gloves represents OutKnocker, a web-based application that facilitates the analysis of deep sequencing data to identify knockout cells obtained from designer nuclease-mediated genome editing. (Cover illustration by Lena Klockenbring, www.lena-klockenbring.de. [For details, see Schmid-Burgk et al., pp. 1719–1723.])

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