Volume 15, Issue 7 | July 2005

ARTICLE
- - Distribution and intensity of constraint in mammalian genomic sequence
    Gregory M. Cooper
    Eric A. Stone
    George Asimenos
    Eric D. Green
    Serafim Batzoglou
    First Published June 17, 2005
LETTERS
- - Punctuated duplication seeding events during the evolution of human chromosome 2p11
    Julie E. Horvath
    Cassandra L. Gulden
    Rhea U. Vallente
    Marla Y. Eichler
    Mario Ventura
    John D. McPherson Tina A. Graves
    ...[+2 authors]...,
    Richard K. Wilson
    Stuart Schwartz
    Mariano Rocchi
    Evan E. Eichler
    First Published June 17, 2005
  - Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease
    Gabriela G. Loots
    Michaela Kneissel
    Hansjoerg Keller
    Myma Baptist
    Jessie Chang
    First Published June 17, 2005
  - Identification of a missense mutation in the bovine ABCG2 gene with a major effect on the QTL on chromosome 6 affecting milk yield and composition in Holstein cattle
    Miri Cohen-Zinder
    Eyal Seroussi
    Denis M. Larkin
    Juan J. Loor
    Annelie Everts-van der Wind
    Jun-Heon Lee James K. Drackley Mark R. Band A.G. Hernandez
    ...[+4 authors]...,
    Moshe Shani
    Harris A. Lewin
    Joel I. Weller
    Micha Ron
    First Published July 5, 2005
  - Assessing the limits of genomic data integration for predicting protein networks
    Long J. Lu
    Yu Xia
    Alberto Paccanaro
    Haiyuan Yu
    Mark Gerstein
    First Published July 5, 2005
  - The net of life: Reconstructing the microbial phylogenetic network
    Victor Kunin
    Leon Goldovsky
    Nikos Darzentas
    Christos A. Ouzounis
    First Published June 17, 2005
Methods
- - On the probability that a novel variant is a disease-causing mutation
    Adele A. Mitchell
    Aravinda Chakravarti
    David J. Cutler
    First Published June 17, 2005
  - Mutation scanning by meltMADGE: Validations using BRCA1 and LDLR, and demonstration of the potential to identify severe, moderate, silent, rare, and paucimorphic mutations in the general population
    Khalid K. Alharbi
    Mohammed A. Aldahmesh
    Emmanuel Spanakis
    Lema Haddad
    Roslyn A. Whittall
    Xiao-he Chen Hamid Rassoulian Matt J. Smith Julie Sillibourne Nicola J. Ball Nikki J. Graham Patricia J. Briggs Iain A. Simpson David I.W. Phillips Deborah A. Lawlor Shu Ye Stephen E. Humphries Cyrus Cooper
    ...[+13 authors]...,
    George Davey Smith
    Shah Ebrahim
    Diana M. Eccles
    Ian N.M. Day
    First Published July 5, 2005
  - Physicochemical constraint violation by missense substitutions mediates impairment of protein function and disease severity
    Eric A. Stone
    Arend Sidow
    First Published June 17, 2005
  - Examples of the complex architecture of the human transcriptome revealed by RACE and high-density tiling arrays
    Philipp Kapranov
    Jorg Drenkow
    Jill Cheng
    Jeffrey Long
    Gregg Helt
    First Published July 5, 2005
  - Orthologous repeats and mammalian phylogenetic inference
    Ali Bashir
    Chun Ye
    Alkes L. Price
    Vineet Bafna
    First Published July 5, 2005
RESOURCES
- - An atlas of human gene expression from massively parallel signature sequencing (MPSS)
    C. Victor Jongeneel
    Mauro Delorenzi
    Christian Iseli
    Daixing Zhou
    Christian D. Haudenschild
    Irina Khrebtukova Dmitry Kuznetsov
    ...[+2 authors]...,
    Brian J. Stevenson
    Robert L. Strausberg
    Andrew J.G. Simpson
    Thomas J. Vasicek
    First Published July 5, 2005
  - The MicrobesOnline Web site for comparative genomics
    Eric J. Alm
    Katherine H. Huang
    Morgan N. Price
    Richard P. Koche
    Keith Keller
    First Published July 5, 2005

Table of Contents

Volume 15, Issue 7 | July 2005

ARTICLE

Distribution and intensity of constraint in mammalian genomic sequence

LETTERS

Punctuated duplication seeding events during the evolution of human chromosome 2p11

Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease

Identification of a missense mutation in the bovine ABCG2 gene with a major effect on the QTL on chromosome 6 affecting milk yield and composition in Holstein cattle

Assessing the limits of genomic data integration for predicting protein networks

The net of life: Reconstructing the microbial phylogenetic network

Methods

On the probability that a novel variant is a disease-causing mutation

Mutation scanning by meltMADGE: Validations using BRCA1 and LDLR, and demonstration of the potential to identify severe, moderate, silent, rare, and paucimorphic mutations in the general population

Physicochemical constraint violation by missense substitutions mediates impairment of protein function and disease severity

Examples of the complex architecture of the human transcriptome revealed by RACE and high-density tiling arrays

Orthologous repeats and mammalian phylogenetic inference

RESOURCES

An atlas of human gene expression from massively parallel signature sequencing (MPSS)

The MicrobesOnline Web site for comparative genomics

Table of Contents

Volume 15, Issue 7 | July 2005

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ARTICLE

LETTERS

Methods

RESOURCES