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Analysis of the Mouse Transcriptome for Genes Involved in the Function of the Nervous System

    • 1Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    • 2Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, USA
    • 3Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    • 4Laboratory for Genome Exploration Research Group, RIKEN Genomic Sciences Center (GSC), RIKEN Yokohama Institute, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan
    • 5Genome Science Laboratory, RIKEN, Hireosawa, Wako, Saitama, 351-0198, Japan
    • 6The Scripps Research Institute, La Jolla, California 92037, USA
    • 7Institute for Molecule Bioscience and ARC Special Research Centre for Functional and Applied Genomics, University of Queensland, Q4072, Australia
    • 8Graduate School of Medicine, University of Tokyo, Tokyo, 113-0033, Japan
    • 9Duke University Medical Center, Department of Neurobiology, Durham, North Carolina 27710, USA
    • 10Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    • 11Department of Psychiatry, University of Bonn, Bonn 53105, Germany
Published June 2, 2003. Vol 13 Issue 6b, pp. 1395-1401. https://doi.org/10.1101/gr.1135303
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cover of Genome Research Vol 36 Issue 5
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Abstract

We analyzed the mouse Representative Transcript and Protein Set for molecules involved in brain function.We found full-length cDNAs of many known brain genes and discovered new members of known brain gene families, including Family 3 G-protein coupled receptors, voltage-gated channels, and connexins.We also identified previously unknown candidates for secreted neuroactive molecules.The existence of a large number of unique brain ESTs suggests an additional molecular complexity that remains to be explored.A list of genes containing CAG stretches in the coding region represents a first step in the potential identification of candidates for hereditary neurological disorders.

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