PERSPECTIVE

Genome Function and Nuclear Architecture: From Gene Expression to Nanoscience

    • 1 The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    • 2 University of Heidelberg, D-69117 Heidelberg, Germany
    • 3 German Cancer Research Center, 69120 Heidelberg, Germany
    • 4 National Cancer Institute, Bethesda, Maryland 20892, USA
    • 5 University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    • 6 MRC Clinical Sciences Centre, London W12 ONN, UK
    • 7 University of Goettingen, 37070 Goettingen, Germany
    • 8 University of Amsterdam, 1018 TV Amsterdam, The Netherlands
Published May 12, 2003. Vol 13 Issue 6a, pp. 1029-1041. https://doi.org/10.1101/gr.946403
Download PDF Please log-in to or register for your personal account in order to access PDF Cite Article Permissions Share
cover of Genome Research Vol 36 Issue 4
Current Issue:
April 2026, Vol. 36, No. 4
Focus view

Abstract

Biophysical, chemical, and nanoscience approaches to the study of nuclear structure and activity have been developing recently and hold considerable promise. A selection of fundamental problems in genome organization and function are reviewed and discussed in the context of these new perspectives and approaches. Advancing these concepts will require coordinated networks of physicists, chemists, and materials scientists collaborating with cell, developmental, and genome biologists.

Back to top
Article contents

Announcement(s)