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Resource

VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing

  • First Published February 2, 2012
Research

Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques

  • First Published February 2, 2012
Research

Age-associated DNA methylation in pediatric populations

  • First Published February 1, 2012
Resource

A vast collection of microbial genes that are toxic to bacteria

  • First Published February 1, 2012
Commentary

An emerging toolkit for targeted cancer therapies

  • First Published February 1, 2012
Perspective

Translating cancer ‘omics’ to improved outcomes

  • First Published February 1, 2012
Perspective

Translational genomics: The challenge of developing cancer biomarkers

  • First Published February 1, 2012
Research

Microevolution of extensively drug-resistant tuberculosis in Russia

  • First Published January 31, 2012
Research

Retrotransposon profiling of RNA polymerase III initiation sites

  • First Published January 27, 2012
Research

Evolutionary rate covariation reveals shared functionality and coexpression of genes

  • First Published January 27, 2012
Research

A multiplicity of factors contributes to selective RNA polymerase III occupancy of a subset of RNA polymerase III genes in mouse liver

  • First Published January 27, 2012
Resource

Functional wiring of the yeast kinome revealed by global analysis of genetic network motifs

  • First Published January 26, 2012
Method

Unified modeling of gene duplication, loss, and coalescence using a locus tree

  • First Published January 23, 2012
Method

Cost-effective, high-throughput DNA sequencing libraries for multiplexed target capture

  • First Published January 20, 2012
Research

The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients

  • First Published January 20, 2012
Research

An ancient genomic regulatory block conserved across bilaterians and its dismantling in tetrapods by retrogene replacement

  • First Published January 10, 2012
Research

Saccharomyces cerevisiae Ty1 retrotransposon" > A nucleosomal surface defines an integration hotspot for the Saccharomyces cerevisiae Ty1 retrotransposon

  • First Published January 4, 2012
Research

Retrotransposon Ty1 integration targets specifically positioned asymmetric nucleosomal DNA segments in tRNA hotspots

  • First Published January 4, 2012
Method

Cell-type-specific nuclei purification from whole animals for genome-wide expression and chromatin profiling

  • First Published January 4, 2012
Research

Comparative RNA sequencing reveals substantial genetic variation in endangered primates

  • First Published December 29, 2011
Method

Ultraconserved elements are novel phylogenomic markers that resolve placental mammal phylogeny when combined with species-tree analysis

  • First Published December 29, 2011
Research

The human phosphotyrosine signaling network: Evolution and hotspots of hijacking in cancer

  • First Published December 22, 2011
Research

Promoter architecture of mouse olfactory receptor genes

  • First Published December 22, 2011
Research

KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing" > A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing

  • First Published December 22, 2011
Research

Genetic control of gene expression in whole blood and lymphoblastoid cell lines is largely independent

  • First Published December 19, 2011
Research

Whole genome sequencing of matched primary and metastatic acral melanomas

  • First Published December 19, 2011
Method

Targeted chromosomal duplications and inversions in the human genome using zinc finger nucleases

  • First Published December 19, 2011
Research

Cooperation between Polycomb and androgen receptor during oncogenic transformation

  • First Published December 16, 2011
Resource

Efficient de novo assembly of large genomes using compressed data structures

  • First Published December 7, 2011
Research

Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer

  • First Published December 7, 2011
Research

MLH1 haploinsufficiency and complete deficiency" > Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency

  • First Published December 7, 2011
Research

SLCO1B1 variation and methotrexate disposition" > Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition

  • First Published December 6, 2011
Resource

GAGE: A critical evaluation of genome assemblies and assembly algorithms

  • First Published December 6, 2011
Research

Disclosing pathogenic genetic variants to research participants: Quantifying an emerging ethical responsibility

  • First Published December 6, 2011
Author Index

Author Index, Volume 21, 2011

  • First Published December 1, 2011
Reviewer Index

Reviewer Index, Volume 21, 2011

  • First Published December 1, 2011
Research

Drosophila melanogaster" > Genome-wide analysis of retrogene polymorphisms in Drosophila melanogaster

  • First Published December 1, 2011
Research

Sequence shortening in the rodent ancestor

  • First Published November 29, 2011
Research

Evolutionary history of novel genes on the tammar wallaby Y chromosome: Implications for sex chromosome evolution

  • First Published November 29, 2011
Method

Genome-wide detection of natural selection in African Americans pre- and post-admixture

  • First Published November 29, 2011
Method

Transposase mediated construction of RNA-seq libraries

  • First Published November 29, 2011
Method

Estimation of alternative splicing variability in human populations

  • First Published November 23, 2011
Resource

Systematic identification of long noncoding RNAs expressed during zebrafish embryogenesis

  • First Published November 22, 2011
Resource

High-resolution mapping of open chromatin in the rice genome

  • First Published November 22, 2011
Research

Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes

  • First Published November 21, 2011
Research

DMD gene" > Aberrant firing of replication origins potentially explains intragenic nonrecurrent rearrangements within genes, including the human DMD gene

  • First Published November 16, 2011
Research

Interlocus gene conversion events introduce deleterious mutations into at least 1% of human genes associated with inherited disease

  • First Published November 16, 2011
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