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Research

Exome-wide assessment of the functional impact and pathogenicity of multinucleotide mutations

  • First Published June 21, 2019
Research

Genome wide analysis of 3′ UTR sequence elements and proteins regulating mRNA stability during maternal-to-zygotic transition in zebrafish

  • First Published June 21, 2019
Research

Haploid selection drives new gene male germline expression

  • First Published June 20, 2019
Research

Deficiency of nucleotide excision repair is associated with mutational signature observed in cancer

  • First Published June 20, 2019
Research

Nascent chromatin occupancy profiling reveals locus- and factor-specific chromatin maturation dynamics behind the DNA replication fork

  • First Published June 19, 2019
Research

Two contrasting classes of nucleolus-associated domains in mouse fibroblast heterochromatin

  • First Published June 14, 2019
Method

Single-molecule long-read sequencing reveals the chromatin basis of gene expression

  • First Published June 14, 2019
Method

A novel synthetic-genetic-array–based yeast one-hybrid system for high discovery rate and short processing time

  • First Published June 11, 2019
Resource

Structural variants identified by Oxford Nanopore PromethION sequencing of the human genome

  • First Published June 11, 2019
Research

Histone methyltransferase PRDM9 is not essential for meiosis in male mice

  • First Published June 11, 2019
In memoriam

Sydney Brenner—a personal perspective

  • First Published June 10, 2019
Research

Xist-induced gene silencing can be predicted from combinations of epigenetic and genomic features" > Kinetics of Xist-induced gene silencing can be predicted from combinations of epigenetic and genomic features

  • First Published June 7, 2019
Method

A machine-learning approach for accurate detection of copy number variants from exome sequencing

  • First Published June 6, 2019
Method

BiosyntheticSPAdes: reconstructing biosynthetic gene clusters from assembly graphs

  • First Published June 3, 2019
Research

Growth disrupting mutations in epigenetic regulatory molecules are associated with abnormalities of epigenetic aging

  • First Published June 3, 2019
Method

methyl-ATAC-seq measures DNA methylation at accessible chromatin

  • First Published June 3, 2019
Research

A massively parallel 3′ UTR reporter assay reveals relationships between nucleotide content, sequence conservation, and mRNA destabilization

  • First Published May 31, 2019
Research

Turnover of ribosome-associated transcripts from de novo ORFs produces gene-like characteristics available for de novo gene emergence in wild yeast populations

  • First Published May 31, 2019
Research

Systems analysis reveals complex biological processes during virus infection fate decisions

  • First Published May 28, 2019
Research

Diversification and collapse of a telomere elongation mechanism

  • First Published May 28, 2019
Method

Crunch: integrated processing and modeling of ChIP-seq data in terms of regulatory motifs

  • First Published May 28, 2019
Resource

Caenorhabditis elegans genome" > Recompleting the Caenorhabditis elegans genome

  • First Published May 23, 2019
Resource

C. elegans" > Long-read sequencing reveals intra-species tolerance of substantial structural variations and new subtelomere formation in C. elegans

  • First Published May 23, 2019
Method

One minute analysis of 200 histone posttranslational modifications by direct injection mass spectrometry

  • First Published May 23, 2019
Research

4q-D4Z4 chromatin architecture regulates the transcription of muscle atrophic genes in facioscapulohumeral muscular dystrophy

  • First Published May 16, 2019
Method

Genome-wide reconstitution of chromatin transactions reveals that RSC preferentially disrupts H2AZ-containing nucleosomes

  • First Published May 16, 2019
Research

Human contamination in bacterial genomes has created thousands of spurious proteins

  • First Published May 7, 2019
Method

Plasmid detection and assembly in genomic and metagenomic data sets

  • First Published May 2, 2019
Research

Convergent recombination cessation between mating-type genes and centromeres in selfing anther-smut fungi

  • First Published May 1, 2019
Erratum

Drosophila genus" > Erratum: Deep experimental profiling of microRNA diversity, deployment, and evolution across the Drosophila genus

  • First Published May 1, 2019
Method

Beta-binomial modeling of CRISPR pooled screen data identifies target genes with greater sensitivity and fewer false negatives

  • First Published April 23, 2019
Method

Laboratory validation of a clinical metagenomic sequencing assay for pathogen detection in cerebrospinal fluid

  • First Published April 16, 2019
Resource

Structural variants in 3000 rice genomes

  • First Published April 16, 2019
Research

Identification of a primitive intestinal transcription factor network shared between esophageal adenocarcinoma and its precancerous precursor state

  • First Published April 8, 2019
Research

Interplay between coding and exonic splicing regulatory sequences

  • First Published April 8, 2019
Research

Drosophila blastoderm" > ATAC-seq reveals regional differences in enhancer accessibility during the establishment of spatial coordinates in the Drosophila blastoderm

  • First Published April 8, 2019
Research

DNA (de)methylation in embryonic stem cells controls CTCF-dependent chromatin boundaries

  • First Published April 4, 2019
Method

A new approach for rare variation collapsing on functional protein domains implicates specific genic regions in ALS

  • First Published April 2, 2019
Method

Efficient and unique cobarcoding of second-generation sequencing reads from long DNA molecules enabling cost-effective and accurate sequencing, haplotyping, and de novo assembly

  • First Published April 2, 2019
Resource

The accessible chromatin landscape of the murine hippocampus at single-cell resolution

  • First Published April 1, 2019
Corrigendum

Corrigendum: Initiation of mtDNA transcription is followed by pausing, and diverges across human cell types and during evolution

  • First Published April 1, 2019
Corrigendum

Corrigendum: H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells

  • First Published April 1, 2019
Resource

Analysis of 100 high-coverage genomes from a pedigreed captive baboon colony

  • First Published March 29, 2019
Research

Brown rat demography reveals pre-commensal structure in eastern Asia before expansion into Southeast Asia

  • First Published March 25, 2019
Research

Enterococcus faecium hospital-adapted lineages in municipal wastewater treatment plants indicates widespread distribution and release into the environment" > Detection of vancomycin-resistant Enterococcus faecium hospital-adapted lineages in municipal wastewater treatment plants indicates widespread distribution and release into the environment

  • First Published March 21, 2019
Research

The origins and evolution of chromosomes, dosage compensation, and mechanisms underlying venom regulation in snakes

  • First Published March 21, 2019
Method

Resolving the full spectrum of human genome variation using Linked-Reads

  • First Published March 20, 2019
Method

Identification of human silencers by correlating cross-tissue epigenetic profiles and gene expression

  • First Published March 18, 2019
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