METHODS

An Assessment of Gene Prediction Accuracy in Large DNA Sequences

• First Published October 1, 2000

REVIEW

Linkage Disequilibrium and the Search for Complex Disease Genes

• First Published October 1, 2000

LETTER

SNP Profile within the Human Major Histocompatibility Complex Reveals an Extreme and Interrupted Level of Nucleotide Diversity

• First Published October 1, 2000

LETTER

Borrelia burgdorferi Linear and Circular Plasmids" > Analyzing DNA Strand Compositional Asymmetry to Identify Candidate Replication Origins of Borrelia burgdorferi Linear and Circular Plasmids

• First Published October 1, 2000

LETTER

D12S1629 and D12S312 at Chromosome 12q13: Triple A Syndrome-Linked Region" > High-Resolution Transcript Map of the Region Spanning D12S1629 and D12S312 at Chromosome 12q13: Triple A Syndrome-Linked Region

• First Published October 1, 2000

LETTER

Eimeria tenella " > A Genetic Linkage Map of the Apicomplexan Protozoan Parasite Eimeria tenella

• First Published October 1, 2000

REPORT

Iroquois Homeobox Genes in Two Clusters Suggests a Conserved Regulation and Function in Vertebrate Development" > Organization of Mouse Iroquois Homeobox Genes in Two Clusters Suggests a Conserved Regulation and Function in Vertebrate Development

• First Published October 1, 2000

METHODS

Normalization and Subtraction of Cap-Trapper-Selected cDNAs to Prepare Full-Length cDNA Libraries for Rapid Discovery of New Genes

• First Published October 1, 2000

METHODS

P Element in Drosophila " > Construction and Transposition of a 100-kilobase Extended P Element in Drosophila

• First Published October 1, 2000

ARTICLE

Biosynthesis of Isoprenoids via Mevalonate in Archaea: The Lost Pathway

• First Published October 1, 2000

INSIGHT/OUTLOOK

Of Mice, Men, and the Genome

• First Published October 1, 2000

LETTER

Maternal Environment and Genotype Interact to Establish Diabesity in Mice

• First Published October 1, 2000

LETTER

Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells

• First Published October 1, 2000

LETTER

Reading between the LINEs: Human Genomic Variation Induced by LINE-1 Retrotransposition

• First Published October 1, 2000

ARTICLE

Potential Gene Conversion and Source Genes for Recently Integrated Alu Elements

• First Published October 1, 2000

LETTER

Triticum dicoccoides: Genome-Wide Coverage, Massive Negative Interference, and Putative Quasi-Linkage" > Molecular Genetic Maps in Wild Emmer Wheat, Triticum dicoccoides: Genome-Wide Coverage, Massive Negative Interference, and Putative Quasi-Linkage

• First Published October 1, 2000

REPORT

HEAT Repeats Associated with Condensins, Cohesins, and Other Complexes Involved in Chromosome-Related Functions

• First Published October 1, 2000

REPORT

Chromosome Evolution: The Junction of Mammalian Chromosomes in the Formation of Mouse Chromosome 10

• First Published October 1, 2000

ARTICLE

Detection of Spurious Interruptions of Protein-Coding Regions in Cloned cDNA Sequences by GeneMark Analysis

• First Published September 1, 2000

LETTER

Identifying Potential Tumor Markers and Antigens by Database Mining and Rapid Expression Screening

• First Published September 1, 2000

METHODS

Rapid Detection of Deletion, Insertion, and Substitution Mutations via Heteroduplex Analysis Using Capillary- and Microchip-Based Electrophoresis

• First Published September 1, 2000

LETTER

An Ordered Comparative Map of the Cattle and Human Genomes

• First Published September 1, 2000

LETTER

Caenorhabditis elegans Chromosomes III and X, with Observations Concerning Odd/Even Biases and Conserved Motifs" > An Annotated Catalog of Inverted Repeats of Caenorhabditis elegans Chromosomes III and X, with Observations Concerning Odd/Even Biases and Conserved Motifs

• First Published September 1, 2000

REPORT

Active Conservation of Noncoding Sequences Revealed by Three-Way Species Comparisons

• First Published September 1, 2000

ARTICLE

Poised for Contagion: Evolutionary Origins of the Infectious Abilities of Invertebrate Retroviruses

• First Published September 1, 2000

METHODS

Plasmodium " > Targeted Terminal Deletions as a Tool for Functional Genomics Studies in Plasmodium

• First Published September 1, 2000

REVIEW

Automation for Genomics, Part Two: Sequencers, Microarrays, and Future Trends

• First Published September 1, 2000

ARTICLE

Alpha Satellite DNA Variant-Specific Oligoprobes Differing by a Single Base Can Distinguish Chromosome 15 Homologs

• First Published September 1, 2000

INSIGHT/OUTLOOK

Unleashing the Canine Genome

• First Published September 1, 2000

COMMENTARY

From Bioinformatics to Computational Biology

• First Published September 1, 2000

REVIEW

Genomic Approaches to Understanding Asthma

• First Published September 1, 2000

LETTER

The Syntenic Relationship of the Zebrafish and Human Genomes

• First Published September 1, 2000

LETTER

Comparative Maps of Human 19p13.3 and Mouse Chromosome 10 Allow Identification of Sequences at Evolutionary Breakpoints

• First Published September 1, 2000

METHODS

DAZ Locus" > Optical Mapping of BAC Clones from the Human Y Chromosome DAZ Locus

• First Published September 1, 2000

ARTICLE

Patterns of Meiotic Recombination on the Long Arm of Human Chromosome 21

• First Published September 1, 2000

LETTER

Alfresco—A Workbench for Comparative Genomic Sequence Analysis

• First Published August 1, 2000

INSIGHT/OUTLOOK

A Chimpanzee Genome Project Is a Biomedical Imperative

• First Published August 1, 2000

REPORT

Trypanosoma cruzi " > Gene Survey of the Pathogenic Protozoan Trypanosoma cruzi

• First Published August 1, 2000

ARTICLE

C. briggsae–C. elegans Genomic Alignment" > Conservation, Regulation, Synteny, and Introns in a Large-scale C. briggsae–C. elegans Genomic Alignment

• First Published August 1, 2000

METHODS

A Quantitative Evaluation of SAGE

• First Published August 1, 2000

INSIGHT/OUTLOOK

WABA Success: A Tool for Sequence Comparison between Large Genomes

• First Published August 1, 2000

REPORT

GT Repeats Are Associated with Recombination on Human Chromosome 22

• First Published August 1, 2000

METHODS

Tissue Gene Expression Analysis Using Arrayed Normalized cDNA Libraries

• First Published August 1, 2000

LETTER

Lgn1 Interval in C57BL/6J Implicates Naip2 or Naip5 in Legionella pneumophila Pathogenesis" > High-resolution Genetic and Physical Map of the Lgn1 Interval in C57BL/6J Implicates Naip2 or Naip5 in Legionella pneumophila Pathogenesis

• First Published August 1, 2000

RESOURCE

Expression-based Genetic/Physical Maps of Single-Nucleotide Polymorphisms Identified by the Cancer Genome Anatomy Project

• First Published August 1, 2000

LETTER

Ecologic Genomics of DNA: Upstream Bending in Prokaryotic Promoters

• First Published August 1, 2000

LETTER

Discovery of a Novel, Paternally Expressed Ubiquitin-specific Processing Protease Gene through Comparative Analysis of an Imprinted Region of Mouse Chromosome 7 and Human Chromosome 19q13.4

• First Published August 1, 2000

METHODS

Loss of Heterozygosity Assay for Molecular Detection of Cancer Using Energy-transfer Primers and Capillary Array Electrophoresis

• First Published August 1, 2000

METHODS

Determination of Single-Nucleotide Polymorphisms by Real-time Pyrophosphate DNA Sequencing

• First Published August 1, 2000

LETTER

Fugu rubripes CFTR and Flanking Genes in a 60 kb Region Conserving Synteny with 800 kb of Human Chromosome 7" > Genomic Sequence Analysis of Fugu rubripes CFTR and Flanking Genes in a 60 kb Region Conserving Synteny with 800 kb of Human Chromosome 7

• First Published August 1, 2000

METHODS

Predicting Protein Function by Genomic Context: Quantitative Evaluation and Qualitative Inferences

• First Published August 1, 2000

ARTICLE

Genome-wide Detection of Allelic Imbalance Using Human SNPs and High-density DNA Arrays

• First Published August 1, 2000

REPORT

Naip Gene Array" > Genomic Sequence Analysis of the Mouse Naip Gene Array

• First Published August 1, 2000

REVIEW

Automation for Genomics, Part One: Preparation for Sequencing

• First Published August 1, 2000

INSIGHT/OUTLOOK

Guilt by Association: Contextual Information in Genome Analysis

• First Published August 1, 2000

METHODS

High-resolution Quantification of Specific mRNA Levels in Human Brain Autopsies and Biopsies

• First Published August 1, 2000

LETTER

Eukaryote-specific Domains in Translation Initiation Factors: Implications for Translation Regulation and Evolution of the Translation System

• First Published August 1, 2000

INSIGHT/OUTLOOK

Are Obese Plant Genomes on a Diet?

• First Published July 1, 2000

REPORT

t-complex DNA" > Eleven Densely Clustered Genes, Six of them Novel, in 176 kb of Mouse t-complex DNA

• First Published July 1, 2000

REVIEW

Minisatellites: Mutability and Genome Architecture

• First Published July 1, 2000

LETTER

From Complete Genomes to Measures of Substitution Rate Variability Within and Between Proteins

• First Published July 1, 2000

LETTER

Drosophila melanogaster " > Molecular Cloning, Genomic Organization, Developmental Regulation, and a Knock-out Mutant of a Novel Leu-rich Repeats-containing G Protein-coupled Receptor (DLGR-2) from Drosophila melanogaster

• First Published July 1, 2000

REPORT

A Contiguous 66-kb Barley DNA Sequence Provides Evidence for Reversible Genome Expansion

• First Published July 1, 2000

RESOURCE

SAGEmap: A Public Gene Expression Resource

• First Published July 1, 2000

LETTER

Rice Transposable Elements: A Survey of 73,000 Sequence-Tagged-Connectors

• First Published July 1, 2000

LETTER

Human and Mouse Gene Structure: Comparative Analysis and Application to Exon Prediction

• First Published July 1, 2000

METHODS

A System for Specific, High-throughput Genotyping by Allele-specific Primer Extension on Microarrays

• First Published July 1, 2000

LETTER

Parking Strategies for Genome Sequencing

• First Published July 1, 2000

LETTER

Tetraodon nigroviridis " > Characterization and Repeat Analysis of the Compact Genome of the Freshwater Pufferfish Tetraodon nigroviridis

• First Published July 1, 2000

INSIGHT/OUTLOOK

“Spot-On” SNP Genotyping

• First Published July 1, 2000

LETTER

Patterns of Variant Polyadenylation Signal Usage in Human Genes

• First Published July 1, 2000

LETTER

Microsatellites in Different Eukaryotic Genomes: Survey and Analysis

• First Published July 1, 2000

LETTER

Distribution of Hammerhead and Hammerhead-like RNA Motifs Through the GenBank

• First Published July 1, 2000

LETTER

Escherichia coli K-12 MG1655" > Reverse Transcriptase-Polymerase Chain Reaction Validation of 25 “Orphan” Genes from Escherichia coli K-12 MG1655

• First Published July 1, 2000

METHODS

Interdigitated Deletion Complexes on Mouse Chromosome 5 Induced by Irradiation of Embryonic Stem Cells

• First Published July 1, 2000

INSIGHT/OUTLOOK

Acquisition and Metastability of Centromere Identity and Function: Sequence Analysis of a Human Neocentromere

• First Published June 1, 2000

LETTER

Parallel Genotyping of Human SNPs Using Generic High-density Oligonucleotide Tag Arrays

• First Published June 1, 2000

LETTER

The 10q25 Neocentromere and its Inactive Progenitor Have Identical Primary Nucleotide Sequence: Further Evidence for Epigenetic Modification

• First Published June 1, 2000

METHODS

Differentially Painting Human Chromosome Arms with Combined Binary Ratio-labeling Fluorescence In Situ Hybridization

• First Published June 1, 2000

LETTER

The Mosaic Structure of Human Pericentromeric DNA: A Strategy for Characterizing Complex Regions of the Human Genome

• First Published June 1, 2000

LETTER

A High-throughput AFLP-based Method for Constructing Integrated Genetic and Physical Maps: Progress Toward a Sorghum Genome Map

• First Published June 1, 2000

ARTICLE

Tandem Clusters of Membrane Proteins in Complete Genome Sequences

• First Published June 1, 2000

METHODS

bronze Region" > A Gene-enriched BAC Library for Cloning Large Allele-specific Fragments from Maize: Isolation of a 240-kb Contig of the bronze Region

• First Published June 1, 2000

METHODS

A Human Genomic Library Enriched in Transcriptionally Active Sequences (aDNA Library)

• First Published June 1, 2000

LETTER

Bpa/Str Region in Mouse and Man" > Comparative Genome Sequence Analysis of the Bpa/Str Region in Mouse and Man

• First Published June 1, 2000

LETTER

Scenedesmus obliquus Reflects an Intermediate Stage in the Evolution of the Green Algal Mitochondrial Genome" > The Complete Mitochondrial DNA Sequence of Scenedesmus obliquus Reflects an Intermediate Stage in the Evolution of the Green Algal Mitochondrial Genome

• First Published June 1, 2000

LETTER

Brassica oleracea and Arabidopsis thaliana " > An EST-enriched Comparative Map of Brassica oleracea and Arabidopsis thaliana

• First Published June 1, 2000

LETTER

Whole-genome Trees Based on the Occurrence of Folds and Orthologs: Implications for Comparing Genomes on Different Levels

• First Published June 1, 2000

ERRATUM

• First Published June 1, 2000

ARTICLE

Conservation of DNA Regulatory Motifs and Discovery of New Motifs in Microbial Genomes

• First Published June 1, 2000

LETTER

PCLN-1/Claudin-16 Results in Bovine Chronic Interstitial Nephritis" > Null Mutation of PCLN-1/Claudin-16 Results in Bovine Chronic Interstitial Nephritis

• First Published May 1, 2000

REVIEW

Structure of Chromosomal Duplicons and their Role in Mediating Human Genomic Disorders

• First Published May 1, 2000

ARTICLE

Alu Elements Support Independent Origin of Prosimian, Platyrrhine, and Catarrhine Mhc-DRB Genes" > Alu Elements Support Independent Origin of Prosimian, Platyrrhine, and Catarrhine Mhc-DRB Genes

• First Published May 1, 2000

REPORT

Comparative Genome Mapping in the Sequence-based Era: Early Experience with Human Chromosome 7

• First Published May 1, 2000

REPORT

Carpodacus mexicanus)" > MHC Class II Pseudogene and Genomic Signature of a 32-kb Cosmid in the House Finch (Carpodacus mexicanus)

• First Published May 1, 2000

LETTER

Nature and Structure of Human Genes that Generate Retropseudogenes

• First Published May 1, 2000

LETTER

Association Between Nuclear Lamin A/C R482Q Mutation and Partial Lipodystrophy with Hyperinsulinemia, Dyslipidemia, Hypertension, and Diabetes

• First Published May 1, 2000

RESOURCE

Construction of a BAC Contig Map of Chromosome 16q by Two-Dimensional Overgo Hybridization

• First Published May 1, 2000

LETTER

Igf2/H19 Imprinting" > Comparative Genomic Sequencing Identifies Novel Tissue-Specific Enhancers and Sequence Elements for Methylation-Sensitive Factors Implicated in Igf2/H19 Imprinting

• First Published May 1, 2000

METHODS

Caenorhabditis elegans by Comparative Proteomics" > Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics

• First Published May 1, 2000