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Research

Integrative phenomics reveals insight into the structure of phenotypic diversity in budding yeast

  • First Published May 29, 2013
Resource

Cell-type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome

  • First Published May 28, 2013
Research

The genomic landscape of cohesin-associated chromatin interactions

  • First Published May 23, 2013
Research

Deletions of recessive disease genes: CNV contribution to carrier states and disease-causing alleles

  • First Published May 16, 2013
Research

Extensive chromosomal reshuffling drives evolution of virulence in an asexual pathogen

  • First Published May 16, 2013
Method

Proteome-wide discovery of mislocated proteins in cancer

  • First Published May 14, 2013
Research

Heliconius butterflies" > Genomic architecture of adaptive color pattern divergence and convergence in Heliconius butterflies

  • First Published May 14, 2013
Research

DNase-seq predicts regions of rotational nucleosome stability across diverse human cell types

  • First Published May 8, 2013
Research

HIV infection reveals widespread expansion of novel centromeric human endogenous retroviruses

  • First Published May 8, 2013
Research

NAHR-mediated copy-number variants in a clinical population: Mechanistic insights into both genomic disorders and Mendelizing traits

  • First Published May 8, 2013
Method

Arboretum: Reconstruction and analysis of the evolutionary history of condition-specific transcriptional modules

  • First Published May 2, 2013
Method

Saccharomyces cerevisiae" > Quantitative proteomic analysis reveals concurrent RNA–protein interactions and identifies new RNA-binding proteins in Saccharomyces cerevisiae

  • First Published May 1, 2013
Research

Social insect genomes exhibit dramatic evolution in gene composition and regulation while preserving regulatory features linked to sociality

  • First Published May 1, 2013
Erratum

Erratum

  • First Published May 1, 2013
Research

Enhancer transcripts mark active estrogen receptor binding sites

  • First Published May 1, 2013
Resource

C. elegans" > The transcription start site landscape of C. elegans

  • First Published May 1, 2013
Method

Mapping functional transcription factor networks from gene expression data

  • First Published May 1, 2013
Resource

The ancestor of extant Japanese fancy mice contributed to the mosaic genomes of classical inbred strains

  • First Published April 19, 2013
Method

Alu insertions in diverse human populations" > Mobile element scanning (ME-Scan) identifies thousands of novel Alu insertions in diverse human populations

  • First Published April 18, 2013
Research

NF-Y coassociates with FOS at promoters, enhancers, repetitive elements, and inactive chromatin regions, and is stereo-positioned with growth-controlling transcription factors

  • First Published April 17, 2013
Method

CG methylated microarrays identify a novel methylated sequence bound by the CEBPB|ATF4 heterodimer that is active in vivo

  • First Published April 16, 2013
Research

Roles for transcript leaders in translation and mRNA decay revealed by transcript leader sequencing

  • First Published April 11, 2013
Research

Maps of open chromatin highlight cell type–restricted patterns of regulatory sequence variation at hematological trait loci

  • First Published April 9, 2013
Method

Cancer translocations in human cells induced by zinc finger and TALE nucleases

  • First Published April 8, 2013
Research

Genome evolution during progression to breast cancer

  • First Published April 8, 2013
Research

Country-specific antibiotic use practices impact the human gut resistome

  • First Published April 8, 2013
Research

Acinetobacter baumannii during patient treatment" > Genomic insights into the fate of colistin resistance and Acinetobacter baumannii during patient treatment

  • First Published April 5, 2013
Method

Porphyromonas gingivalis recovered from a biofilm in a hospital sink using a high-throughput single-cell genomics platform" > Genome of the pathogen Porphyromonas gingivalis recovered from a biofilm in a hospital sink using a high-throughput single-cell genomics platform

  • First Published April 5, 2013
Method

Comprehensive prediction in 78 human cell lines reveals rigidity and compactness of transcription factor dimers

  • First Published April 3, 2013
Method

Inferring chromatin-bound protein complexes from genome-wide binding assays

  • First Published April 3, 2013
Resource

C. elegans reveals promoter and enhancer architectures" > The landscape of RNA polymerase II transcription initiation in C. elegans reveals promoter and enhancer architectures

  • First Published April 2, 2013
Research

A dynamic H3K27ac signature identifies VEGFA-stimulated endothelial enhancers and requires EP300 activity

  • First Published April 1, 2013
Erratum

Erratum

  • First Published April 1, 2013
Research

C. elegans insulin networks" > Complex expression dynamics and robustness in C. elegans insulin networks

  • First Published March 28, 2013
Research

Gene expression drives local adaptation in humans

  • First Published March 28, 2013
Research

HCFC1 is a common component of active human CpG-island promoters and coincides with ZNF143, THAP11, YY1, and GABP transcription factor occupancy

  • First Published March 28, 2013
Method

Chlamydia trachomatis directly from clinical samples without culture" > Whole-genome sequences of Chlamydia trachomatis directly from clinical samples without culture

  • First Published March 22, 2013
Research

Widespread and extensive lengthening of 3′ UTRs in the mammalian brain

  • First Published March 21, 2013
Research

Systematic dissection of regulatory motifs in 2000 predicted human enhancers using a massively parallel reporter assay

  • First Published March 19, 2013
Research

DNA-methylation effect on cotranscriptional splicing is dependent on GC architecture of the exon–intron structure

  • First Published March 15, 2013
Method

Nearly finished genomes produced using gel microdroplet culturing reveal substantial intraspecies genomic diversity within the human microbiome

  • First Published March 14, 2013
Research

Patterns of regulatory activity across diverse human cell types predict tissue identity, transcription factor binding, and long-range interactions

  • First Published March 12, 2013
Method

Targeted chromosomal deletions and inversions in zebrafish

  • First Published March 11, 2013
Research

The origin, evolution, and functional impact of short insertion–deletion variants identified in 179 human genomes

  • First Published March 11, 2013
Research

Drosophila Cys2-His2 zinc finger proteins reveals a multitude of novel recognition motifs and binding determinants" > Global analysis of Drosophila Cys2-His2 zinc finger proteins reveals a multitude of novel recognition motifs and binding determinants

  • First Published March 7, 2013
Research

High-resolution DNA methylome analysis of primordial germ cells identifies gender-specific reprogramming in mice

  • First Published February 14, 2013
Research

Breakpoint profiling of 64 cancer genomes reveals numerous complex rearrangements spawned by homology-independent mechanisms

  • First Published February 14, 2013
Resource

Genome-wide bimolecular fluorescence complementation analysis of SUMO interactome in yeast

  • First Published February 12, 2013
Research

Two DNA-encoded strategies for increasing expression with opposing effects on promoter dynamics and transcriptional noise

  • First Published February 12, 2013
Research

Temporal mapping of CEBPA and CEBPB binding during liver regeneration reveals dynamic occupancy and specific regulatory codes for homeostatic and cell cycle gene batteries

  • First Published February 12, 2013
Research

A genome-wide RNA interference screen identifies new regulators of androgen receptor function in prostate cancer cells

  • First Published February 12, 2013
Resource

PRISM offers a comprehensive genomic approach to transcription factor function prediction

  • First Published February 4, 2013
Resource

A large-scale zebrafish gene knockout resource for the genome-wide study of gene function

  • First Published February 4, 2013
Method

Single molecule molecular inversion probes for targeted, high-accuracy detection of low-frequency variation

  • First Published February 4, 2013
Erratum

Erratum

  • First Published February 1, 2013
Research

High-throughput sequencing reveals extraordinary fluidity of miRNA, piRNA, and siRNA pathways in nematodes

  • First Published January 30, 2013
Resource

A cross-platform analysis of 14,177 expression quantitative trait loci derived from lymphoblastoid cell lines

  • First Published January 23, 2013
Research

Analysis of CDS-located miRNA target sites suggests that they can effectively inhibit translation

  • First Published January 18, 2013
Resource

Dynamic DNA methylation across diverse human cell lines and tissues

  • First Published January 16, 2013
Method

RNA-seq–based mapping and candidate identification of mutations from forward genetic screens

  • First Published January 8, 2013
Method

MMAPPR: Mutation Mapping Analysis Pipeline for Pooled RNA-seq

  • First Published January 8, 2013
Research

Staphylococcus aureus pandemic" > A genomic portrait of the emergence, evolution, and global spread of a methicillin-resistant Staphylococcus aureus pandemic

  • First Published January 8, 2013
Method

Structure-based whole-genome realignment reveals many novel noncoding RNAs

  • First Published January 7, 2013
Method

An integrative variant analysis pipeline for accurate genotype/haplotype inference in population NGS data

  • First Published January 7, 2013
Method

Sequencing of isolated sperm cells for direct haplotyping of a human genome

  • First Published January 2, 2013
Method

Arabidopsis by manipulating DNA repair pathways" > Increasing frequencies of site-specific mutagenesis and gene targeting in Arabidopsis by manipulating DNA repair pathways

  • First Published January 2, 2013
Research

Saccharomyces cerevisiae using the genetic tug-of-war method" > Identification of dosage-sensitive genes in Saccharomyces cerevisiae using the genetic tug-of-war method

  • First Published December 28, 2012
Research

CHH islands: de novo DNA methylation in near-gene chromatin regulation in maize

  • First Published December 26, 2012
Method

ATARiS: Computational quantification of gene suppression phenotypes from multisample RNAi screens

  • First Published December 26, 2012
Method

Mapping genomic hotspots of DNA damage by a single-strand-DNA-compatible and strand-specific ChIP-seq method

  • First Published December 17, 2012
Method

High-resolution mapping, characterization, and optimization of autonomously replicating sequences in yeast

  • First Published December 12, 2012
Research

Drosophila dosage compensation complex revealed by high-shear ChIP-seq" > Different chromatin interfaces of the Drosophila dosage compensation complex revealed by high-shear ChIP-seq

  • First Published December 11, 2012
Method

Genotype imputation via matrix completion

  • First Published December 10, 2012
Research

TRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells

  • First Published December 10, 2012
Resource

Drosophila melanogaster based on population-scale sequencing" > Impact of genomic structural variation in Drosophila melanogaster based on population-scale sequencing

  • First Published December 6, 2012
Research

PRDM9 associated with childhood leukemogenesis" > Rare allelic forms of PRDM9 associated with childhood leukemogenesis

  • First Published December 5, 2012
Method

Highly active zinc-finger nucleases by extended modular assembly

  • First Published December 5, 2012
Research

DAXX-dependent supply of soluble (H3.3–H4) dimers to PML bodies pending deposition into chromatin

  • First Published December 5, 2012
Research

Somatic neurofibromatosis type 1 (NF1) inactivation characterizes NF1-associated pilocytic astrocytoma

  • First Published December 5, 2012
Research

Camponotus floridanus" > A chromatin link to caste identity in the carpenter ant Camponotus floridanus

  • First Published December 3, 2012
Research

Spatial congregation of STAT binding directs selective nuclear architecture during T-cell functional differentiation

  • First Published December 3, 2012
Research

Nonallelic homologous recombination between retrotransposable elements is a driver of de novo unbalanced translocations

  • First Published December 3, 2012
Author Index

Author Index, Volume 22, 2012

  • First Published December 1, 2012
Reviewer Index

Reviewer Index, Volume 22, 2012

  • First Published December 1, 2012
Method

iReckon: Simultaneous isoform discovery and abundance estimation from RNA-seq data

  • First Published November 29, 2012
Method

DANPOS: Dynamic analysis of nucleosome position and occupancy by sequencing

  • First Published November 28, 2012
Research

Genome-wide mapping of human DNA-replication origins: Levels of transcription at ORC1 sites regulate origin selection and replication timing

  • First Published November 27, 2012
Research

GATA3 acts upstream of FOXA1 in mediating ESR1 binding by shaping enhancer accessibility

  • First Published November 21, 2012
Method

Obligate Ligation-Gated Recombination (ObLiGaRe): Custom-designed nuclease-mediated targeted integration through nonhomologous end joining

  • First Published November 14, 2012
Research

Correlated alterations in genome organization, histone methylation, and DNA–lamin A/C interactions in Hutchinson-Gilford progeria syndrome

  • First Published November 14, 2012
Resource

Pyrus bretschneideri Rehd.)" > The genome of the pear (Pyrus bretschneideri Rehd.)

  • First Published November 13, 2012
Research

Functional genomic analysis of chromosomal aberrations in a compendium of 8000 cancer genomes

  • First Published November 6, 2012
Method

Genome-scale coestimation of species and gene trees

  • First Published November 6, 2012
Research

Targeted gene silencing in mouse germ cells by insertion of a homologous DNA into a piRNA generating locus

  • First Published November 6, 2012
Research

Constitutive nuclear lamina–genome interactions are highly conserved and associated with A/T-rich sequence

  • First Published November 2, 2012
Research

Somatic rearrangements across cancer reveal classes of samples with distinct patterns of DNA breakage and rearrangement-induced hypermutability

  • First Published November 2, 2012
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