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Method

Short template switch events explain mutation clusters in the human genome

  • First Published April 6, 2017
Resource

Drosophila melanogaster" > The developmental proteome of Drosophila melanogaster

  • First Published April 5, 2017
Research

Dynamic RNA–protein interactions underlie the zebrafish maternal-to-zygotic transition

  • First Published April 5, 2017
Method

Direct determination of diploid genome sequences

  • First Published April 5, 2017
Perspective

Moving beyond Bermuda: sharing data to build a medical information commons

  • First Published April 3, 2017
Research

Drosophila melanogaster" > Single-molecule sequencing resolves the detailed structure of complex satellite DNA loci in Drosophila melanogaster

  • First Published April 3, 2017
Research

TERT aberrations in acral melanoma" > Integrated genomic analyses reveal frequent TERT aberrations in acral melanoma

  • First Published April 3, 2017
Corrigendum

Corrigendum: A novel translational control mechanism involving RNA structures within coding sequences

  • First Published April 3, 2017
Review

Genome graphs and the evolution of genome inference

  • First Published March 30, 2017
Method

MHC haplotypes reveal extreme coding variation in genes other than highly polymorphic HLA class I and II" > Sequences of 95 human MHC haplotypes reveal extreme coding variation in genes other than highly polymorphic HLA class I and II

  • First Published March 30, 2017
Research

Combination of short-read, long-read, and optical mapping assemblies reveals large-scale tandem repeat arrays with population genetic implications

  • First Published March 30, 2017
Research

Mechanisms of precise genome editing using oligonucleotide donors

  • First Published March 29, 2017
Research

Transcriptional regulatory dynamics drive coordinated metabolic and neural response to social challenge in mice

  • First Published March 29, 2017
Research

Combinatorial DNA methylation codes at repetitive elements

  • First Published March 27, 2017
Method

RNA-DNA hybrid (R-loop) immunoprecipitation mapping: an analytical workflow to evaluate inherent biases

  • First Published March 24, 2017
Research

PML protein organizes heterochromatin domains where it regulates histone H3.3 deposition by ATRX/DAXX

  • First Published March 24, 2017
Research

Small chromosomal regions position themselves autonomously according to their chromatin class

  • First Published March 24, 2017
Research

Diurnal regulation of RNA polymerase III transcription is under the control of both the feeding–fasting response and the circadian clock

  • First Published March 24, 2017
Research

In vivo binding of PRDM9 reveals interactions with noncanonical genomic sites

  • First Published March 23, 2017
Resource

Burkholderia cenocepacia during long-term chronic infection of cystic fibrosis lungs" > Phenotypic diversity and genotypic flexibility of Burkholderia cenocepacia during long-term chronic infection of cystic fibrosis lungs

  • First Published March 21, 2017
Research

Pan-cancer analysis distinguishes transcriptional changes of aneuploidy from proliferation

  • First Published March 20, 2017
Method

HINGE: long-read assembly achieves optimal repeat resolution

  • First Published March 20, 2017
Research

Time-dependent genetic effects on gene expression implicate aging processes

  • First Published March 16, 2017
Method

metaSPAdes: a new versatile metagenomic assembler

  • First Published March 15, 2017
Method

k-mer weighting and repeat separation" > Canu: scalable and accurate long-read assembly via adaptive k-mer weighting and repeat separation

  • First Published March 15, 2017
Research

Speciation network in Laurasiatheria: retrophylogenomic signals

  • First Published March 15, 2017
Research

Genome-wide analysis of differential RNA editing in epilepsy

  • First Published March 1, 2017
Corrigendum

Corrigendum: Large-scale mapping of gene regulatory logic reveals context-dependent repression by transcriptional activators

  • First Published March 1, 2017
Research

One thousand somatic SNVs per skin fibroblast cell set baseline of mosaic mutational load with patterns that suggest proliferative origin

  • First Published February 24, 2017
Method

ABySS 2.0: resource-efficient assembly of large genomes using a Bloom filter

  • First Published February 23, 2017
Research

Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells

  • First Published February 23, 2017
Research

Transcriptome analyses of rhesus monkey preimplantation embryos reveal a reduced capacity for DNA double-strand break repair in primate oocytes and early embryos

  • First Published February 21, 2017
Research

Arabidopsis is unaltered by extreme divergence in CENH3 protein sequence" > Centromere location in Arabidopsis is unaltered by extreme divergence in CENH3 protein sequence

  • First Published February 21, 2017
Research

Distal CpG islands can serve as alternative promoters to transcribe genes with silenced proximal promoters

  • First Published February 21, 2017
Research

Genome surgery using Cas9 ribonucleoproteins for the treatment of age-related macular degeneration

  • First Published February 16, 2017
Method

Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations

  • First Published February 8, 2017
Research

Single-cell transcriptomics of the human placenta: inferring the cell communication network of the maternal-fetal interface

  • First Published February 7, 2017
Method

Microbial strain-level population structure and genetic diversity from metagenomes

  • First Published February 6, 2017
Method

Improving and correcting the contiguity of long-read genome assemblies of three plant species using optical mapping and chromosome conformation capture data

  • First Published February 3, 2017
Corrigendum

Corrigendum: Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes

  • First Published February 1, 2017
Research

Improved genome assembly of American alligator genome reveals conserved architecture of estrogen signaling

  • First Published January 30, 2017
Method

Aegilops tauschii, a progenitor of bread wheat, with the MaSuRCA mega-reads algorithm" > Hybrid assembly of the large and highly repetitive genome of Aegilops tauschii, a progenitor of bread wheat, with the MaSuRCA mega-reads algorithm

  • First Published January 27, 2017
Resource

Large-scale analysis of branchpoint usage across species and cell lines

  • First Published January 24, 2017
Method

HySA: a Hybrid Structural variant Assembly approach using next-generation and single-molecule sequencing technologies

  • First Published January 19, 2017
Method

Fast and accurate de novo genome assembly from long uncorrected reads

  • First Published January 18, 2017
Method

UMI-tools: modeling sequencing errors in Unique Molecular Identifiers to improve quantification accuracy

  • First Published January 18, 2017
Research

Single-cell transcriptome analysis of fish immune cells provides insight into the evolution of vertebrate immune cell types

  • First Published January 13, 2017
Research

Novel determinants of mammalian primary microRNA processing revealed by systematic evaluation of hairpin-containing transcripts and human genetic variation

  • First Published January 13, 2017
Research

TRUB1 is the predominant pseudouridine synthase acting on mammalian mRNA via a predictable and conserved code

  • First Published January 10, 2017
Research

Identical bacterial populations colonize premature infant gut, skin, and oral microbiomes and exhibit different in situ growth rates

  • First Published January 10, 2017
Method

Reciprocal insulation analysis of Hi-C data shows that TADs represent a functionally but not structurally privileged scale in the hierarchical folding of chromosomes

  • First Published January 5, 2017
Research

N6-methyladenosine in primates" > Evolution of transcript modification by N6-methyladenosine in primates

  • First Published January 4, 2017
Research

Initiation of mtDNA transcription is followed by pausing, and diverges across human cell types and during evolution

  • First Published January 3, 2017
Research

A-to-I RNA editing promotes developmental stage–specific gene and lncRNA expression

  • First Published December 28, 2016
Research

Transcription factor assisted loading and enhancer dynamics dictate the hepatic fasting response

  • First Published December 28, 2016
Resource

Genetic compendium of 1511 human brains available through the UK Medical Research Council Brain Banks Network Resource

  • First Published December 21, 2016
Method

Alu repeats delineates the structural and functional genomic architecture of colon cancer cells" > The epigenetic landscape of Alu repeats delineates the structural and functional genomic architecture of colon cancer cells

  • First Published December 20, 2016
Method

Using reference-free compressed data structures to analyze sequencing reads from thousands of human genomes

  • First Published December 16, 2016
Research

Comparative analyses of super-enhancers reveal conserved elements in vertebrate genomes

  • First Published December 13, 2016
Research

Large-scale mapping of gene regulatory logic reveals context-dependent repression by transcriptional activators

  • First Published December 13, 2016
Research

Engineered LINE-1 retrotransposition in nondividing human neurons

  • First Published December 13, 2016
Research

Bacillus subtilis genome: consequences for the transcriptional network, resource allocation, and metabolism" > Large-scale reduction of the Bacillus subtilis genome: consequences for the transcriptional network, resource allocation, and metabolism

  • First Published December 13, 2016
Research

Reconstructing genetic history of Siberian and Northeastern European populations

  • First Published December 13, 2016
Research

APOBEC3A/B-induced mutagenesis is responsible for 20% of heritable mutations in the TpCpW context

  • First Published December 9, 2016
Research

A GC-rich sequence feature in the 3′ UTR directs UPF1-dependent mRNA decay in mammalian cells

  • First Published December 9, 2016
Method

HapCUT2: robust and accurate haplotype assembly for diverse sequencing technologies

  • First Published December 9, 2016
Research

Evolutionary patterns of metazoan microRNAs reveal targeting principles in the let-7 and miR-10 families

  • First Published December 7, 2016
Research

Chromatin environment, transcriptional regulation, and splicing distinguish lincRNAs and mRNAs

  • First Published December 7, 2016
Research

Characterization of hundreds of regulatory landscapes in developing limbs reveals two regimes of chromatin folding

  • First Published December 6, 2016
Research

Numerical and spatial patterning of yeast meiotic DNA breaks by Tel1

  • First Published December 6, 2016
Corrigendum

Corrigendum: Replication timing is regulated by the number of MCMs loaded at origins

  • First Published December 1, 2016
Reviewer Index

Reviewer Index, Volume 26, 2016

  • First Published December 1, 2016
Research

EP300 and CREBBP" > Whole-transcriptome sequencing identifies a distinct subtype of acute lymphoblastic leukemia with predominant genomic abnormalities of EP300 and CREBBP

  • First Published November 30, 2016
Resource

Upgrading short-read animal genome assemblies to chromosome level using comparative genomics and a universal probe set

  • First Published November 30, 2016
Resource

A reference data set of 5.4 million phased human variants validated by genetic inheritance from sequencing a three-generation 17-member pedigree

  • First Published November 30, 2016
Research

Enhancers and super-enhancers have an equivalent regulatory role in embryonic stem cells through regulation of single or multiple genes

  • First Published November 28, 2016
Research

Nucleosome occupancy as a novel chromatin parameter for replication origin functions

  • First Published November 28, 2016
Research

Discovery and genotyping of structural variation from long-read haploid genome sequence data

  • First Published November 28, 2016
Method

Detecting differential growth of microbial populations with Gaussian process regression

  • First Published November 18, 2016
Research

Single-cell transcriptomes identify human islet cell signatures and reveal cell-type–specific expression changes in type 2 diabetes

  • First Published November 18, 2016
Method

The dynamic landscape of fission yeast meiosis alternative-splice isoforms

  • First Published November 17, 2016
Resource

Multiparameter functional diversity of human C2H2 zinc finger proteins

  • First Published November 16, 2016
Method

Integrating transcriptomic and proteomic data for accurate assembly and annotation of genomes

  • First Published November 15, 2016
Research

microRNA target prediction programs predict many false positives

  • First Published November 15, 2016
Method

Identification of complex genomic rearrangements in cancers using CouGaR

  • First Published November 14, 2016
Research

Genome-wide uniformity of human ‘open’ pre-initiation complexes

  • First Published November 10, 2016
Research

A systematic comparison reveals substantial differences in chromosomal versus episomal encoding of enhancer activity

  • First Published November 9, 2016
Research

The evolution of inflorescence diversity in the nightshades and heterochrony during meristem maturation

  • First Published November 7, 2016
Research

A novel translational control mechanism involving RNA structures within coding sequences

  • First Published November 7, 2016
Corrigendum

Corrigendum: Characterization of the neural stem cell gene regulatory network identifies OLIG2 as a multifunctional regulator of self-renewal

  • First Published November 1, 2016
Method

An integrated 3-Dimensional Genome Modeling Engine for data-driven simulation of spatial genome organization

  • First Published October 27, 2016
Method

A privacy-preserving solution for compressed storage and selective retrieval of genomic data

  • First Published October 27, 2016
Research

DPPA3 are bypassed during pluripotency- and differentiation-coupled methylation reprogramming in testicular germ cell tumors" > Imprints and DPPA3 are bypassed during pluripotency- and differentiation-coupled methylation reprogramming in testicular germ cell tumors

  • First Published October 20, 2016
Research

LTR-mediated retroposition as a mechanism of RNA-based duplication in metazoans

  • First Published October 20, 2016
Method

Quantification of in vivo progenitor mutation accrual with ultra-low error rate and minimal input DNA using SIP-HAVA-seq

  • First Published October 19, 2016
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