Your search for returned 6,372 results
Method
netNMF-sc: leveraging gene–gene interactions for imputation and dimensionality reduction in single-cell expression analysis
- First Published January 28, 2020
Resource
Organ-level protein networks as a reference for the host effects of the microbiome
- First Published January 28, 2020
Method
Ancestry-agnostic estimation of DNA sample contamination from sequence reads
- First Published January 24, 2020
Research
HOTAIR regulatory element modulates glioma cell sensitivity to temozolomide through long-range regulation of multiple target genes" > A HOTAIR regulatory element modulates glioma cell sensitivity to temozolomide through long-range regulation of multiple target genes
- First Published January 17, 2020
Resource
A comparison of gene expression and DNA methylation patterns across tissues and species
- First Published January 17, 2020
Corrigendum
Corrigendum: Dynamics of cardiomyocyte transcriptome and chromatin landscape demarcates key events of heart development
- First Published January 9, 2020
Corrigendum
Corrigendum: Murine single-cell RNA-seq reveals cell-identity- and tissue-specific trajectories of aging
- First Published January 9, 2020
Method
MOCHI enables discovery of heterogeneous interactome modules in 3D nucleome
- First Published January 6, 2020
Method
Streptococcus thermophilus CRISPR1-Cas9" > Versatile and robust genome editing with Streptococcus thermophilus CRISPR1-Cas9
- First Published January 3, 2020
Research
Asymmetric repair of UV damage in nucleosomes imposes a DNA strand polarity on somatic mutations in skin cancer
- First Published December 23, 2019
Method
Identification of pathogenic variant enriched regions across genes and gene families
- First Published December 23, 2019
Method
Predicting transfer RNA gene activity from sequence and genome context
- First Published December 19, 2019
Research
Characterizing the nuclear and cytoplasmic transcriptomes in developing and mature human cortex uncovers new insight into psychiatric disease gene regulation
- First Published December 18, 2019
Research
Heterodimerization of TFAP2 pioneer factors drives epigenomic remodeling during neural crest specification
- First Published December 17, 2019
Resource
Phosphoproteomic profiling reveals a defined genetic program for osteoblastic lineage commitment of human bone marrow–derived stromal stem cells
- First Published December 12, 2019
Resource
Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9
- First Published December 12, 2019
Research
PRANCR as a novel regulator of epidermal homeostasis" > A genome-wide long noncoding RNA CRISPRi screen identifies PRANCR as a novel regulator of epidermal homeostasis
- First Published December 4, 2019
Method
Identifying gene function and module connections by the integration of multispecies expression compendia
- First Published November 21, 2019
Method
Modeling Niemann–Pick disease type C in a human haploid cell line allows for patient variant characterization and clinical interpretation
- First Published November 21, 2019
Resource
Murine single-cell RNA-seq reveals cell-identity- and tissue-specific trajectories of aging
- First Published November 21, 2019
Research
A high-resolution gene expression atlas links dedicated meristem genes to key architectural traits
- First Published November 19, 2019
Research
Chromatin-sensitive cryptic promoters putatively drive expression of alternative protein isoforms in yeast
- First Published November 18, 2019
Research
Promoter-specific dynamics of TATA-binding protein association with the human genome
- First Published November 15, 2019
Method
Deep profiling and custom databases improve detection of proteoforms generated by alternative splicing
- First Published November 14, 2019
Method
Copolymerization of single-cell nucleic acids into balls of acrylamide gel
- First Published November 14, 2019
Method
Drosophila genes conserved in humans" > CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans
- First Published November 13, 2019
Research
Clonal copy-number mosaicism in autoreactive T lymphocytes in diabetic NOD mice
- First Published November 6, 2019
Method
AIDE: annotation-assisted isoform discovery with high precision
- First Published November 6, 2019
Method
Saccharomyces cerevisiae genome" > Absolute nucleosome occupancy map for the Saccharomyces cerevisiae genome
- First Published November 6, 2019
Research
Drosophila metabolome" > Systems genetics of the Drosophila metabolome
- First Published November 6, 2019
Method
Network-based hierarchical population structure analysis for large genomic data sets
- First Published November 6, 2019
Research
Synchronized replication of genes encoding the same protein complex in fast-proliferating cells
- First Published October 29, 2019
Method
Single-pollen-cell sequencing for gamete-based phased diploid genome assembly in plants
- First Published October 24, 2019
Method
Identification and dynamic quantification of regulatory elements using total RNA
- First Published October 24, 2019
Resource
A chromosome-level assembly of the Atlantic herring genome—detection of a supergene and other signals of selection
- First Published October 24, 2019
Resource
Genes essential for embryonic stem cells are associated with neurodevelopmental disorders
- First Published October 24, 2019
Research
Megalobrama amblycephala × Culter alburnus" > The subgenomes show asymmetric expression of alleles in hybrid lineages of Megalobrama amblycephala × Culter alburnus
- First Published October 24, 2019
Method
FFPEcap-seq: a method for sequencing capped RNAs in formalin-fixed paraffin-embedded samples
- First Published October 24, 2019
Resource
Dynamics of microRNA expression during mouse prenatal development
- First Published October 23, 2019
Method
PhISCS: a combinatorial approach for subperfect tumor phylogeny reconstruction via integrative use of single-cell and bulk sequencing data
- First Published October 18, 2019
Method
SiCloneFit: Bayesian inference of population structure, genotype, and phylogeny of tumor clones from single-cell genome sequencing data
- First Published October 18, 2019
Research
Pedigree-based estimation of human mobile element retrotransposition rates
- First Published October 1, 2019
Research
Paramecium tetraurelia" > Environmentally induced plasticity of programmed DNA elimination boosts somatic variability in Paramecium tetraurelia
- First Published September 23, 2019
Method
Quantitative mitochondrial DNA copy number determination using droplet digital PCR with single-cell resolution
- First Published September 23, 2019
Research
Regional epigenetic differentiation of the Z Chromosome between sexes in a female heterogametic system
- First Published September 23, 2019
Research
Saccharomyces hybrids" > Fitness benefits of loss of heterozygosity in Saccharomyces hybrids
- First Published September 23, 2019
Resource
Discovery of high-confidence human protein-coding genes and exons by whole-genome PhyloCSF helps elucidate 118 GWAS loci
- First Published September 19, 2019
Research
The strand-biased mitochondrial DNA methylome and its regulation by DNMT3A
- First Published September 19, 2019
Research
LTR retroelement expansion of the human cancer transcriptome and immunopeptidome revealed by de novo transcript assembly
- First Published September 19, 2019
Research
cis-regulatory convergence between the extinct Tasmanian tiger and gray wolf" > Widespread cis-regulatory convergence between the extinct Tasmanian tiger and gray wolf
- First Published September 18, 2019
Research
Transcriptional alterations in glioma result primarily from DNA methylation–independent mechanisms
- First Published September 18, 2019
Research
Sequence determinants of polyadenylation-mediated regulation
- First Published September 17, 2019
Research
Nascent transcript analysis of glucocorticoid crosstalk with TNF defines primary and cooperative inflammatory repression
- First Published September 13, 2019
Method
Gene expression profiling of single cells from archival tissue with laser-capture microdissection and Smart-3SEQ
- First Published September 13, 2019
Research
Global analyses of the dynamics of mammalian microRNA metabolism
- First Published September 13, 2019
Research
A-to-I RNA editing contributes to the persistence of predicted damaging mutations in populations
- First Published September 12, 2019
Method
A novel assay to screen siRNA libraries identifies protein kinases required for chromosome transmission
- First Published September 12, 2019
Research
Dynamic reversal of random X-Chromosome inactivation during iPSC reprogramming
- First Published September 12, 2019
Research
Accessibility of promoter DNA is not the primary determinant of chromatin-mediated gene regulation
- First Published September 11, 2019
Research
The 22q11 low copy repeats are characterized by unprecedented size and structural variability
- First Published September 3, 2019
Corrigendum
C. elegans and human cancers" > Corrigendum: Mutational signatures of DNA mismatch repair deficiency in C. elegans and human cancers
- First Published September 3, 2019
Method
Discovering human transcription factor physical interactions with genetic variants, novel DNA motifs, and repetitive elements using enhanced yeast one-hybrid assays
- First Published September 3, 2019
Corrigendum
Drosophila melanogaster" > Corrigendum: A long-term demasculinization of X-linked intergenic noncoding RNAs in Drosophila melanogaster
- First Published September 3, 2019
Research
Fabp4 to white adipocytes ameliorates obesity, inflammation, hepatic steatosis, and insulin resistance" > Targeted delivery of CRISPR interference system against Fabp4 to white adipocytes ameliorates obesity, inflammation, hepatic steatosis, and insulin resistance
- First Published August 29, 2019
Method
Direct RNA nanopore sequencing of full-length coronavirus genomes provides novel insights into structural variants and enables modification analysis
- First Published August 22, 2019
Resource
Pediatric Cancer Variant Pathogenicity Information Exchange (PeCanPIE): a cloud-based platform for curating and classifying germline variants
- First Published August 22, 2019
Research
Escherichia coli reveals that bovine-adapted E. coli lineages are serving as evolutionary sources of the emergence of human intestinal pathogenic strains" > Large-scale genome analysis of bovine commensal Escherichia coli reveals that bovine-adapted E. coli lineages are serving as evolutionary sources of the emergence of human intestinal pathogenic strains
- First Published August 22, 2019
Resource
Exploration of fine-scale recombination rate variation in the domestic horse
- First Published August 21, 2019
Research
RNA components of the spliceosome regulate tissue- and cancer-specific alternative splicing
- First Published August 21, 2019
Research
Replication timing networks reveal a link between transcription regulatory circuits and replication timing control
- First Published August 21, 2019
Perspective
Decrypting noncoding RNA interactions, structures, and functional networks
- First Published August 21, 2019
Research
A high resolution A-to-I editing map in the mouse identifies editing events controlled by pre-mRNA splicing
- First Published August 19, 2019
Research
Distinct types of short open reading frames are translated in plant cells
- First Published August 6, 2019
Research
Estrogen-independent molecular actions of mutant estrogen receptor 1 in endometrial cancer
- First Published July 30, 2019
Method
Identifying loci under positive selection in complex population histories
- First Published July 30, 2019
Research
Whole-genome sequencing reveals high complexity of copy number variation at insecticide resistance loci in malaria mosquitoes
- First Published July 25, 2019
Resource
Benchmark and integration of resources for the estimation of human transcription factor activities
- First Published July 24, 2019
Research
Glucocorticoid receptor quaternary structure drives chromatin occupancy and transcriptional outcome
- First Published July 23, 2019
Research
Characterization of functional relationships of R-loops with gene transcription and epigenetic modifications in rice
- First Published July 1, 2019
Research
High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma
- First Published June 27, 2019
Method
Estimation of allele-specific fitness effects across human protein-coding sequences and implications for disease
- First Published June 27, 2019
Research
Local features determine Ty3 targeting frequency at RNA polymerase III transcription start sites
- First Published June 27, 2019
Method
Efficient and flexible tagging of endogenous genes by homology-independent intron targeting
- First Published June 25, 2019
Research
Capture of a functionally active methyl-CpG binding domain by an arthropod retrotransposon family
- First Published June 25, 2019
Method
Genetic variant pathogenicity prediction trained using disease-specific clinical sequencing data sets
- First Published June 24, 2019
Method
OMA standalone: orthology inference among public and custom genomes and transcriptomes
- First Published June 24, 2019
Research
Exome-wide assessment of the functional impact and pathogenicity of multinucleotide mutations
- First Published June 21, 2019