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Research

Comprehensive analysis of structural variants in breast cancer genomes using single-molecule sequencing

  • First Published September 4, 2020
Research

Long-read sequencing for non-small-cell lung cancer genomes

  • First Published September 4, 2020
Method

Background-suppressed live visualization of genomic loci with an improved CRISPR system based on a split fluorophore

  • First Published September 4, 2020
Method

Native molecule sequencing by nano-ID reveals synthesis and stability of RNA isoforms

  • First Published September 4, 2020
Method

High-throughput single-cell functional elucidation of neurodevelopmental disease–associated genes reveals convergent mechanisms altering neuronal differentiation

  • First Published September 4, 2020
Method

The Nubeam reference-free approach to analyze metagenomic sequencing reads

  • First Published September 3, 2020
Method

Pooled analysis of radiation hybrids identifies loci for growth and drug action in mammalian cells

  • First Published September 2, 2020
Research

Mapping genome variation of SARS-CoV-2 worldwide highlights the impact of COVID-19 super-spreaders

  • First Published September 2, 2020
Method

Neisseria gonorrhoeae variant and antimicrobial resistance calling from metagenomic Nanopore sequencing" > High precision Neisseria gonorrhoeae variant and antimicrobial resistance calling from metagenomic Nanopore sequencing

  • First Published September 1, 2020
Method

Metabolic labeling of RNA using multiple ribonucleoside analogs enables the simultaneous evaluation of RNA synthesis and degradation rates

  • First Published August 25, 2020
Research

LCM-seq reveals unique transcriptional adaptation mechanisms of resistant neurons and identifies protective pathways in spinal muscular atrophy

  • First Published August 20, 2020
Research

Chromatin activation as a unifying principle underlying pathogenic mechanisms in multiple myeloma

  • First Published August 20, 2020
Research

Populus deltoides" > Xylem systems genetics analysis reveals a key regulator of lignin biosynthesis in Populus deltoides

  • First Published August 19, 2020
Method

Detection of simple and complex de novo mutations with multiple reference sequences

  • First Published August 19, 2020
Method

A pedigree-based prediction model identifies carriers of deleterious de novo mutations in families with Li-Fraumeni syndrome

  • First Published August 18, 2020
Method

RNA-Bloom enables reference-free and reference-guided sequence assembly for single-cell transcriptomes

  • First Published August 17, 2020
Method

TransBorrow: genome-guided transcriptome assembly by borrowing assemblies from different assemblers

  • First Published August 17, 2020
Method

Detection and characterization of jagged ends of double-stranded DNA in plasma

  • First Published August 14, 2020
Method

HiCanu: accurate assembly of segmental duplications, satellites, and allelic variants from high-fidelity long reads

  • First Published August 14, 2020
Research

SHANK2 as a tumor suppressor in neuroblastoma" > Somatic structural variation targets neurodevelopmental genes and identifies SHANK2 as a tumor suppressor in neuroblastoma

  • First Published August 13, 2020
Research

Diploid genome architecture revealed by multi-omic data of hybrid mice

  • First Published August 5, 2020
Research

Arabidopsis" > HDA6-dependent histone deacetylation regulates mRNA polyadenylation in Arabidopsis

  • First Published August 5, 2020
Research

PR-DUB maintains the expression of critical genes through FOXK1/2- and ASXL1/2/3-dependent recruitment to chromatin and H2AK119ub1 deubiquitination

  • First Published August 3, 2020
Method

Cross-species analysis of enhancer logic using deep learning

  • First Published July 30, 2020
Method

The multicomparative 2-n-way genome suite

  • First Published July 29, 2020
Research

ADAR-deficiency perturbs the global splicing landscape in mouse tissues

  • First Published July 29, 2020
Resource

A limited set of transcriptional programs define major cell types

  • First Published July 29, 2020
Research

Comparative transcriptomics of primary cells in vertebrates

  • First Published July 27, 2020
Resource

Functional annotation of human long noncoding RNAs via molecular phenotyping

  • First Published July 27, 2020
Research

Binding specificities of human RNA-binding proteins toward structured and linear RNA sequences

  • First Published July 23, 2020
Research

Transcriptome-wide sites of collided ribosomes reveal principles of translational pausing

  • First Published July 23, 2020
Research

Independent evolution of transcript abundance and gene regulatory dynamics

  • First Published July 22, 2020
Method

Parallel bimodal single-cell sequencing of transcriptome and chromatin accessibility

  • First Published July 22, 2020
Research

Translation initiation downstream from annotated start codons in human mRNAs coevolves with the Kozak context

  • First Published July 15, 2020
Corrigendum

Corrigendum: OMA standalone: orthology inference among public and custom genomes and transcriptomes

  • First Published July 14, 2020
Corrigendum

Corrigendum: Human auditory ossicles as an alternative optimal source of ancient DNA

  • First Published July 14, 2020
Research

Single-cell analysis of human embryos reveals diverse patterns of aneuploidy and mosaicism

  • First Published July 8, 2020
Research

Characterization of colibactin-associated mutational signature in an Asian oral squamous cell carcinoma and in other mucosal tumor types

  • First Published July 6, 2020
Method

A long-read RNA-seq approach to identify novel transcripts of very large genes

  • First Published July 6, 2020
Method

TRACE: transcription factor footprinting using chromatin accessibility data and DNA sequence

  • First Published July 6, 2020
Method

Simple and efficient profiling of transcription initiation and transcript levels with STRIPE-seq

  • First Published July 6, 2020
Resource

LEMMI: a continuous benchmarking platform for metagenomics classifiers

  • First Published July 2, 2020
Research

Dissecting the regulatory activity and sequence content of loci with exceptional numbers of transcription factor associations

  • First Published July 2, 2020
Resource

Dynamic transcriptional and chromatin accessibility landscape of medaka embryogenesis

  • First Published June 26, 2020
Research

Untangling the effects of cellular composition on coexpression analysis

  • First Published June 24, 2020
Research

Coexpression enrichment analysis at the single-cell level reveals convergent defects in neural progenitor cells and their cell-type transitions in neurodevelopmental disorders

  • First Published June 18, 2020
Research

Drosophila brain" > The evolution of sex-biased gene expression in the Drosophila brain

  • First Published June 18, 2020
Method

+ RNA interactome reveal insights into organization and function of RNA–protein complexes" > System-wide analyses of the fission yeast poly(A)+ RNA interactome reveal insights into organization and function of RNA–protein complexes

  • First Published June 18, 2020
Method

Ultralow-input single-tube linked-read library method enables short-read second-generation sequencing systems to routinely generate highly accurate and economical long-range sequencing information

  • First Published June 15, 2020
Research

Quantitative analysis of Y-Chromosome gene expression across 36 human tissues

  • First Published May 27, 2020
Research

Paternal age in rhesus macaques is positively associated with germline mutation accumulation but not with measures of offspring sociability

  • First Published May 27, 2020
Method

Exploring dimension-reduced embeddings with Sleepwalk

  • First Published May 19, 2020
Method

Determining the impact of uncharacterized inversions in the human genome by droplet digital PCR

  • First Published May 18, 2020
Research

Global fitness landscapes of the Shine-Dalgarno sequence

  • First Published May 18, 2020
Research

Sense–antisense miRNA pairs constitute an elaborate reciprocal regulatory circuit

  • First Published May 18, 2020
Research

Candida parapsilosis" > Polymorphic centromere locations in the pathogenic yeast Candida parapsilosis

  • First Published May 18, 2020
Method

MEDEA: analysis of transcription factor binding motifs in accessible chromatin

  • First Published May 18, 2020
Resource

Comprehensive analyses of 723 transcriptomes enhance genetic and biological interpretations for complex traits in cattle

  • First Published May 18, 2020
Method

Bombyx mori" > Genome-wide CRISPR screening reveals genes essential for cell viability and resistance to abiotic and biotic stresses in Bombyx mori

  • First Published May 18, 2020
Resource

Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brains

  • First Published May 18, 2020
Method

CRISPR-Cas9-mediated pinpoint microbial genome editing aided by target-mismatched sgRNAs

  • First Published April 23, 2020
Research

Mecp2-null mice implicate the DNA damage response in Rett syndrome pathology" > Suppressor mutations in Mecp2-null mice implicate the DNA damage response in Rett syndrome pathology

  • First Published April 21, 2020
Method

Complete characterization of the human immune cell transcriptome using accurate full-length cDNA sequencing

  • First Published April 20, 2020
Method

Characterizing and inferring quantitative cell cycle phase in single-cell RNA-seq data analysis

  • First Published April 20, 2020
Research

Arabidopsis retrotransposon virus-like particles and their regulation by epigenetically activated small RNA" > Arabidopsis retrotransposon virus-like particles and their regulation by epigenetically activated small RNA

  • First Published April 17, 2020
Research

Dynamic effects of interacting genes underlying rice flowering-time phenotypic plasticity and global adaptation

  • First Published April 16, 2020
Research

HPF1 controls yeast chronological aging" > Intragenic repeat expansion in the cell wall protein gene HPF1 controls yeast chronological aging

  • First Published April 10, 2020
Research

Noncoding regions underpin avian bill shape diversification at macroevolutionary scales

  • First Published April 8, 2020
Research

Redundant and specific roles of cohesin STAG subunits in chromatin looping and transcriptional control

  • First Published April 6, 2020
Research

Rapid evolution of piRNA-mediated silencing of an invading transposable element was driven by abundant de novo mutations

  • First Published April 1, 2020
Corrigendum

Corrigendum: Convergent recombination cessation between mating-type genes and centromeres in selfing anther-smut fungi

  • First Published March 25, 2020
Research

Comprehensive analysis of indels in whole-genome microsatellite regions and microsatellite instability across 21 cancer types

  • First Published March 24, 2020
Method

Transcriptome reconstruction and functional analysis of eukaryotic marine plankton communities via high-throughput metagenomics and metatranscriptomics

  • First Published March 23, 2020
Review

Accurate and complete genomes from metagenomes

  • First Published March 18, 2020
Method

Inhibition of transcription leads to rewiring of locus-specific chromatin proteomes

  • First Published March 18, 2020
Method

Time course regulatory analysis based on paired expression and chromatin accessibility data

  • First Published March 18, 2020
Research

Identification of FMR1-regulated molecular networks in human neurodevelopment

  • First Published March 16, 2020
Resource

Integrated annotations and analyses of small RNA–producing loci from 47 diverse plants

  • First Published March 16, 2020
Research

Tetrahymena thermophila" > Rearrangement of macronucleus chromosomes correspond to TAD-like structures of micronucleus chromosomes in Tetrahymena thermophila

  • First Published March 12, 2020
Method

Genomic loci susceptible to systematic sequencing bias in clinical whole genomes

  • First Published March 10, 2020
Resource

Drosophila Genetic Reference Panel" > Gene expression networks in the Drosophila Genetic Reference Panel

  • First Published March 6, 2020
Resource

An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis

  • First Published March 4, 2020
Method

C. elegans to mammals" > Analysis of Hi-C data using SIP effectively identifies loops in organisms from C. elegans to mammals

  • First Published March 3, 2020
Method

RETrace: simultaneous retrospective lineage tracing and methylation profiling of single cells

  • First Published March 3, 2020
Research

Genome-wide, integrative analysis of circular RNA dysregulation and the corresponding circular RNA-microRNA-mRNA regulatory axes in autism

  • First Published March 3, 2020
Method

Human auditory ossicles as an alternative optimal source of ancient DNA

  • First Published February 25, 2020
Resource

Recounting the FANTOM CAGE-Associated Transcriptome

  • First Published February 20, 2020
Corrigendum

Corrigendum: Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites

  • First Published February 20, 2020
Method

Assembly-free single-molecule sequencing recovers complete virus genomes from natural microbial communities

  • First Published February 19, 2020
Method

Dual threshold optimization and network inference reveal convergent evidence from TF binding locations and TF perturbation responses

  • First Published February 14, 2020
Method

TraDIS-Xpress: a high-resolution whole-genome assay identifies novel mechanisms of triclosan action and resistance

  • First Published February 12, 2020
Resource

A time-resolved multi-omic atlas of the developing mouse liver

  • First Published February 12, 2020
Research

Cannabis sativa" > An efficient RNA-seq-based segregation analysis identifies the sex chromosomes of Cannabis sativa

  • First Published February 7, 2020
Research

Alternative polyadenylation drives oncogenic gene expression in pancreatic ductal adenocarcinoma

  • First Published February 6, 2020
Resource

Caenorhabditis elegans development" > Direct full-length RNA sequencing reveals unexpected transcriptome complexity during Caenorhabditis elegans development

  • First Published February 5, 2020
Resource

C. elegans using direct RNA sequencing" > The full-length transcriptome of C. elegans using direct RNA sequencing

  • First Published February 5, 2020
Method

Deep neural networks for interpreting RNA-binding protein target preferences

  • First Published January 28, 2020
Method

SHARP: hyperfast and accurate processing of single-cell RNA-seq data via ensemble random projection

  • First Published January 28, 2020
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