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Research

Dynamics and consequences of differential RNA isoform production during cardiomyocyte fate determination and early-stage maturation

  • Joanna Delimata-Raczek
  • Natalia Koralewska
  • Bart Krist
  • Magdalena Rakoczy
  • Marek Figlerowicz
  • Ireneusz Stolarek
  • First Published April 3, 2026
Method

Incorporating valuable prior knowledge to improve deep learning prediction of genetic perturbation responses

  • Xiuhao Fu
  • Chao Yang
  • Chunyan Cui
  • Aoyun Geng
  • Yidi Sun
  • Chao Zha Feifei Cui
  • ... [+2 authors] ...,
  • Leyi Wei
  • Quan Zou
  • Xin Gao
  • Zilong Zhang
  • First Published March 26, 2026
Resource

Isoform- and pathway-specific regulation of post-transcriptional RNA processing in human cells

  • Ishwarya Venkata Narayanan
  • Karan Bedi
  • Brian Magnuson
  • Ariel McShane
  • Mario Ashaka
  • Michelle Paulsen
  • Thomas E Wilson
  • Mats Ljungman
  • First Published March 26, 2026
Method

High-fidelity bidirectional translation between single-cell transcriptomes and DNA methylomes with scBOND

  • Kehan Lang
  • Chenyang Jia
  • Siyu Li
  • Yi Guo
  • Dingjun Hu
  • Shengquan Chen
  • First Published March 26, 2026
Research

Centromeric instability and chromoanasynthesis observed in nine supernumerary marker chromosomes resolved with long-read genome sequencing

  • Kristine Bilgrav Saether
  • Angelo Salazar Mantero
  • Marlene Ek
  • Maria Pettersson
  • Elisabeth Syk Lundberg
  • Christopher M. Grochowski
  • Claudia M.B. Carvalho
  • Jesper Eisfeldt
  • Anna Lindstrand
  • First Published March 25, 2026
Research

ACTB methylation regulates SMARCA4 genomic occupancy to promote translation and reduce adhesion in colorectal cancer cells

  • Elina Abaev-Schneiderman
  • Linh Nguyen
  • Raz Shalev
  • Tzofit Elbaz Biton
  • Anand Chopra
  • Giritharan Jagadeesan Daniel Sevilla-Sanchez Nili Tickotsky Moskovitz
  • ... [+3 authors] ...,
  • Liron Levin
  • Michal Feldman
  • Capucine Van Rechem
  • Dan Levy
  • First Published March 25, 2026
Method

Complete genetic and epigenetic architecture of D4Z4 macrosatellites in FSHD, BAMS, and reference cohorts with D4Z4End2End

  • Lucinda C. Xiao
  • Ayush Semwal
  • Brianna St John
  • Kathleen Zeglinski
  • Shian Su
  • James Lancaster Shifeng Xue Bruno Reversade
  • ... [+3 authors] ...,
  • Matthew E. Ritchie
  • Frédérique Magdinier
  • Marnie E. Blewitt
  • Quentin Gouil
  • First Published March 23, 2026
Research

Aphelenchus avenae implicates P5CS in nematode desiccation stress response" > Haplotype-resolved telomere-to-telomere genome of Aphelenchus avenae implicates P5CS in nematode desiccation stress response

  • Yali Zhang
  • Yayi Zhou
  • Yangyang Chen
  • Xueyu Wang
  • Boyan Hu
  • Shahid Siddique Romnick A. Latina Veronica I. Casey Dexin Bo Yucheng Liao
  • ... [+5 authors] ...,
  • Min Zhang
  • Ming Sun
  • Fengjuan Zhang
  • Dadong Dai
  • First Published March 23, 2026
Method

k-mer cross-species profiling reveals taxon-specific TE expansions accompanied by KZFP co-option and functional impacts in ruminants" > k-mer cross-species profiling reveals taxon-specific TE expansions accompanied by KZFP co-option and functional impacts in ruminants

  • Pengju Zhao
  • Jiayi He
  • Chen Peng
  • Yuelang Zhang
  • Chong Wang
  • Dongyou Yu
  • Lingzhao Fang
  • Zhengguang Wang
  • First Published March 23, 2026
Method

High-resolution genotype-free mapping of genetic variation with CRI-SPA-Map

  • Sheila Lutz
  • Megan Lawler
  • Samuel Amidon
  • Frank W. Albert
  • First Published March 23, 2026
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