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Artificial intelligence and machine learning in cell-free-DNA-based diagnostics

W.H. Adrian Tsui
Spencer C. Ding
Peiyong Jiang
Y.M. Dennis Lo

First Published January 22, 2025

Analysis of a cell-free DNA–based cancer screening cohort links fragmentomic profiles, nuclease levels, and plasma DNA concentrations

Yasine Malki
Guannan Kang
W.K. Jacky Lam
Qing Zhou
Suk Hang Cheng
Peter P.H. Cheung Jinyue Bai Ming Lok Chan Chui Ting Lee Wenlei Peng Yiqiong Zhang Wanxia Gai Winsome W.S. Wong Mary-Jane L. Ma Wenshuo Li Xinzhou Xu Zhuoran Gao Irene O.L. Tse Huimin Shang
... [+14 authors] ...,
L.Y. Lois Choy
Peiyong Jiang
K.C. Allen Chan
Y.M. Dennis Lo

First Published November 27, 2024

Genomic origin, fragmentomics, and transcriptional properties of long cell-free DNA molecules in human plasma

Huiwen Che
Peiyong Jiang
L.Y. Lois Choy
Suk Hang Cheng
Wenlei Peng
Rebecca W.Y. Chan Jing Liu Qing Zhou W.K. Jacky Lam Stephanie C.Y. Yu So Ling Lau Tak Y. Leung John Wong Vincent Wai-Sun Wong
... [+9 authors] ...,
Grace L.H. Wong
Stephen L. Chan
K.C. Allen Chan
Y.M. Dennis Lo

First Published February 26, 2024

Nuclease deficiencies alter plasma cell-free DNA methylation profiles

Diana S.C. Han
Meng Ni
Rebecca W.Y. Chan
Danny K.L. Wong
Linda T. Hiraki
Stefano Volpi Peiyong Jiang
... [+2 authors] ...,
Kathy O. Lui
K.C. Allen Chan
Rossa W.K. Chiu
Y.M. Dennis Lo

First Published September 1, 2021

Detection and characterization of jagged ends of double-stranded DNA in plasma

Peiyong Jiang
Tingting Xie
Spencer C. Ding
Ze Zhou
Suk Hang Cheng
Rebecca W.Y. Chan Wing-Shan Lee Wenlei Peng John Wong Vincent W.S. Wong Henry L.Y. Chan Stephen L. Chan Liona C.Y. Poon
... [+8 authors] ...,
Tak Y. Leung
K.C. Allen Chan
Rossa W.K. Chiu
Y.M. Dennis Lo

First Published August 14, 2020

Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin

Kun Sun
Peiyong Jiang
Suk Hang Cheng
Timothy H.T. Cheng
John Wong
Vincent W.S. Wong Simon S.M. Ng Brigette B.Y. Ma Tak Y. Leung Stephen L. Chan Tony S.K. Mok Paul B.S. Lai Henry L.Y. Chan
... [+8 authors] ...,
Hao Sun
K.C. Allen Chan
Rossa W.K. Chiu
Y.M. Dennis Lo

First Published February 26, 2019

Computational analysis of genome-wide DNA methylation during the differentiation of human embryonic stem cells along the endodermal lineage

Lukas Chavez
Justyna Jozefczuk
Christina Grimm
Jörn Dietrich
Bernd Timmermann
Hans Lehrach
Ralf Herwig
James Adjaye

First Published August 27, 2010

Deeply conserved chordate noncoding sequences preserve genome synteny but do not drive gene duplicate retention

Andrew L. Hufton
Susanne Mathia
Helene Braun
Udo Georgi
Hans Lehrach
Martin Vingron
Albert J. Poustka
Georgia Panopoulou

First Published August 24, 2009

Early vertebrate whole genome duplications were predated by a period of intense genome rearrangement

Andrew L. Hufton
Detlef Groth
Martin Vingron
Hans Lehrach
Albert J. Poustka
Georgia Panopoulou

First Published July 14, 2008

Arabidopsis Functional Genomics: Transcript Profiling and Reverse Genetics Applications" > Versatile Gene-Specific Sequence Tags for Arabidopsis Functional Genomics: Transcript Profiling and Reverse Genetics Applications

Pierre Hilson
Joke Allemeersch
Thomas Altmann
Sébastien Aubourg
Alexandra Avon
Jim Beynon Rishikesh P. Bhalerao Frédérique Bitton Michel Caboche Bernard Cannoot Vasil Chardakov Cécile Cognet-Holliger Vincent Colot Mark Crowe Caroline Darimont Steffen Durinck Holger Eickhoff Andéol Falcon de Longevialle Edward E. Farmer Murray Grant Martin T.R. Kuiper Hans Lehrach Céline Léon Antonio Leyva Joakim Lundeberg Claire Lurin Yves Moreau Wilfried Nietfeld Javier Paz-Ares Philippe Reymond Pierre Rouzé Goran Sandberg Maria Dolores Segura Carine Serizet Alexandra Tabrett Ludivine Taconnat Vincent Thareau Paul Van Hummelen Steven Vercruysse Marnik Vuylsteke Magdalena Weingartner Peter J. Weisbeek
... [+37 authors] ...,
Valtteri Wirta
Floyd R.A. Wittink
Marc Zabeau
Ian Small

First Published October 15, 2004

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