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In memoriam

Jim Watson (1928–2025): a genomics visionary

  • First Published July 23, 2026
Method

Profiling the quantitative occupancy of myriad transcription factors across conditions by modeling chromatin accessibility data

  • First Published May 24, 2022
In memoriam

C. Thomas Caskey (1938–2022)

  • First Published February 17, 2022
In memoriam

Deborah A. Nickerson (1954 –2021)

  • First Published January 24, 2022
Method

cis-regulatory elements, their cognate transcription factors, and regulatory DNA sequence variants" > Human cardiac cis-regulatory elements, their cognate transcription factors, and regulatory DNA sequence variants

  • First Published August 23, 2018
Research

Glucocorticoid receptor recruits to enhancers and drives activation by motif-directed binding

  • First Published August 10, 2018
Corrigendum

Corrigendum: Characterization of the neural stem cell gene regulatory network identifies OLIG2 as a multifunctional regulator of self-renewal

  • First Published December 1, 2017
Research

Microbiota regulate intestinal epithelial gene expression by suppressing the transcription factor Hepatocyte nuclear factor 4 alpha

  • First Published April 6, 2017
Corrigendum

Corrigendum: Characterization of the neural stem cell gene regulatory network identifies OLIG2 as a multifunctional regulator of self-renewal

  • First Published November 1, 2016
Method

Mapping nucleosome positions using DNase-seq

  • First Published January 15, 2016
Research

Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators

  • First Published May 29, 2015
Research

Genome accessibility is widely preserved and locally modulated during mitosis

  • First Published November 4, 2014
Research

Characterization of the neural stem cell gene regulatory network identifies OLIG2 as a multifunctional regulator of self-renewal

  • First Published October 7, 2014
Research

Microbiota modulate transcription in the intestinal epithelium without remodeling the accessible chromatin landscape

  • First Published June 24, 2014
Research

DNase-seq predicts regions of rotational nucleosome stability across diverse human cell types

  • First Published May 8, 2013
Research

A dynamic H3K27ac signature identifies VEGFA-stimulated endothelial enhancers and requires EP300 activity

  • First Published April 1, 2013
Research

Patterns of regulatory activity across diverse human cell types predict tissue identity, transcription factor binding, and long-range interactions

  • First Published March 12, 2013
Resource

Dynamic DNA methylation across diverse human cell lines and tissues

  • First Published January 16, 2013
Method

Predicting cell-type–specific gene expression from regions of open chromatin

  • First Published September 5, 2012
Research

Effects of sequence variation on differential allelic transcription factor occupancy and gene expression

  • First Published February 2, 2012
Resource

High-resolution mapping of open chromatin in the rice genome

  • First Published November 22, 2011
Research

Cell-type specific and combinatorial usage of diverse transcription factors revealed by genome-wide binding studies in multiple human cells

  • First Published November 16, 2011
Research

Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration

  • First Published July 27, 2011
Resource

Open chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity

  • First Published July 12, 2011
Research

XIST locus" > Comparative analysis of the primate X-inactivation center region and reconstruction of the ancestral primate XIST locus

  • First Published April 25, 2011
Method

High-resolution genome-wide in vivo footprinting of diverse transcription factors in human cells

  • First Published November 24, 2010
Method

Systematic comparison of three genomic enrichment methods for massively parallel DNA sequencing

  • First Published September 1, 2010
Resource

The completion of the Mammalian Gene Collection (MGC)

  • First Published September 18, 2009
Resource

The ClinSeq Project: Piloting large-scale genome sequencing for research in genomic medicine

  • First Published July 14, 2009
Letter

Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns

  • First Published February 27, 2009
LETTER

Comparative sequence analysis of primate subtelomeres originating from a chromosome fission event

  • First Published October 24, 2008
ARTICLE

Analyses of deep mammalian sequence alignments and constraint predictions for 1% of the human genome

  • First Published June 13, 2007
RESOURCE

Xenopus laevis and Xenopus tropicalis reveals post-tetraploidization transcriptome remodeling" > Sequencing and analysis of 10,967 full-length cDNA clones from Xenopus laevis and Xenopus tropicalis reveals post-tetraploidization transcriptome remodeling

  • First Published May 3, 2006
LETTER

A preliminary comparative analysis of primate segmental duplications shows elevated substitution rates and a great-ape expansion of intrachromosomal duplications

  • First Published April 10, 2006
Methods

Genome-wide mapping of DNase hypersensitive sites using massively parallel signature sequencing (MPSS)

  • First Published December 12, 2005
ARTICLE

Distribution and intensity of constraint in mammalian genomic sequence

  • First Published June 17, 2005
LETTER

Reconstructing large regions of an ancestral mammalian genome in silico

  • First Published December 1, 2004
LETTER

An intermediate grade of finished genomic sequence suitable for comparative analyses

  • First Published October 12, 2004
RESOURCE

Aligning Multiple Genomic Sequences With the Threaded Blockset Aligner

  • First Published April 1, 2004
ARTICLE

Identification and Characterization of Multi-Species Conserved Sequences

  • First Published December 1, 2003
LETTER

Quantitative Estimates of Sequence Divergence for Comparative Analyses of Mammalian Genomes

  • First Published May 1, 2003
METHODS

LAGAN and Multi-LAGAN: Efficient Tools for Large-Scale Multiple Alignment of Genomic DNA

  • First Published March 12, 2003
LETTER

Analysis of Primate Genomic Variation Reveals a Repeat-Driven Expansion of the Human Genome

  • First Published March 1, 2003
LETTER

Pericentromeric Duplications in the Laboratory Mouse

  • First Published December 30, 2002
METHODS

Parallel Construction of Orthologous Sequence-Ready Clone Contig Maps in Multiple Species

  • First Published August 1, 2002
REPORT

3.3 Mb of Mouse Genomic Sequence Orthologous to the Region of Human Chromosome 7q11.23 Implicated in Williams Syndrome " > Generation and Comparative Analysis of ∼3.3 Mb of Mouse Genomic Sequence Orthologous to the Region of Human Chromosome 7q11.23 Implicated in Williams Syndrome

  • First Published January 1, 2002
COMMENTARY

The Human Genome Sequence Expedition: Views from the “Base Camp”

  • First Published May 1, 2001
REPORT

Comparative Genome Mapping in the Sequence-based Era: Early Experience with Human Chromosome 7

  • First Published May 1, 2000
REPORT

CTNS): Complete Sequencing of a 200-kb Segment and Discovery of a Novel Gene within the Common Cystinosis-Causing Deletion" > The Genomic Region Encompassing the Nephropathic Cystinosis Gene (CTNS): Complete Sequencing of a 200-kb Segment and Discovery of a Novel Gene within the Common Cystinosis-Causing Deletion

  • First Published February 1, 2000
LETTER

CMT2D Locus: Refined Genetic Position and Construction of a Bacterial Clone-Based Physical Map" > The CMT2D Locus: Refined Genetic Position and Construction of a Bacterial Clone-Based Physical Map

  • First Published June 1, 1999
LETTER

Comparative Mapping of the Region of Human Chromosome 7 Deleted in Williams Syndrome

  • First Published May 1, 1999
LETTER

High Throughput Fingerprint Analysis of Large-Insert Clones

  • First Published November 1, 1997
RESEARCH

A Physical Map of Human Chromosome 7: An Integrated YAC Contig Map with Average STS Spacing of 79 kb

  • First Published July 1, 1997
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