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Research

CRX classifies clinical variants and reveals biochemical properties of the transcriptional effector domain" > Mutational scanning of CRX classifies clinical variants and reveals biochemical properties of the transcriptional effector domain

James L. Shepherdson
David M. Granas
Jie Li
Zara Shariff
Stephen P. Plassmeyer
Alex S. Holehouse
Michael A. White
Barak A. Cohen

First Published September 25, 2024

Research

CRX have distinct cis-regulatory effects on enhancers and silencers in photoreceptors" > Pathogenic variants in CRX have distinct cis-regulatory effects on enhancers and silencers in photoreceptors

James L. Shepherdson
Ryan Z. Friedman
Yiqiao Zheng
Chi Sun
Inez Y. Oh
David M. Granas
Barak A. Cohen
Shiming Chen
Michael A. White

First Published February 14, 2024

Research

Functional characterization of enhancer activity during a long terminal repeat's evolution

Alan Y. Du
Xiaoyu Zhuo
Vasavi Sundaram
Nicholas O. Jensen
Hemangi G. Chaudhari
Nancy L. Saccone
Barak A. Cohen
Ting Wang

First Published October 3, 2022

Research

Genomic environments scale the activities of diverse core promoters

Clarice K.Y. Hong
Barak A. Cohen

First Published December 27, 2021

Research

cis-regulatory activity" > Local sequence features that influence AP-1 cis-regulatory activity

Hemangi G. Chaudhari
Barak A. Cohen

First Published January 5, 2018

Research

cis-regulation in embryonic stem cells" > Interactions between pluripotency factors specify cis-regulation in embryonic stem cells

Chris Fiore
Barak A. Cohen

First Published April 15, 2016

Research

Promoter-distal RNA polymerase II binding discriminates active from inactive CCAAT/ enhancer-binding protein beta binding sites

Daniel Savic
Brian S. Roberts
Julia B. Carleton
E. Christopher Partridge
Michael A. White
Barak A. Cohen
Gregory M. Cooper
Jason Gertz
Richard M. Myers

First Published October 20, 2015

Research

High-throughput functional testing of ENCODE segmentation predictions

Jamie C. Kwasnieski
Christopher Fiore
Hemangi G. Chaudhari
Barak A. Cohen

First Published July 17, 2014

Method

Massively parallel synthetic promoter assays reveal the in vivo effects of binding site variants

Ilaria Mogno
Jamie C. Kwasnieski
Barak A. Cohen

First Published August 6, 2013

Method

Computational analysis of genome-wide DNA methylation during the differentiation of human embryonic stem cells along the endodermal lineage

Lukas Chavez
Justyna Jozefczuk
Christina Grimm
Jörn Dietrich
Bernd Timmermann
Hans Lehrach
Ralf Herwig
James Adjaye

First Published August 27, 2010

Research

TATA is a modular component of synthetic promoters

Ilaria Mogno
Francesco Vallania
Robi D. Mitra
Barak A. Cohen

First Published July 13, 2010

Letter

Deeply conserved chordate noncoding sequences preserve genome synteny but do not drive gene duplicate retention

Andrew L. Hufton
Susanne Mathia
Helene Braun
Udo Georgi
Hans Lehrach
Martin Vingron
Albert J. Poustka
Georgia Panopoulou

First Published August 24, 2009

LETTER

Early vertebrate whole genome duplications were predated by a period of intense genome rearrangement

Andrew L. Hufton
Detlef Groth
Martin Vingron
Hans Lehrach
Albert J. Poustka
Georgia Panopoulou

First Published July 14, 2008

Methods

Discovery, validation, and genetic dissection of transcription factor binding sites by comparative and functional genomics

Jason Gertz
Linda Riles
Peter Turnbaugh
Su-Wen Ho
Barak A. Cohen

First Published August 2, 2005

RESOURCE

Arabidopsis Functional Genomics: Transcript Profiling and Reverse Genetics Applications" > Versatile Gene-Specific Sequence Tags for Arabidopsis Functional Genomics: Transcript Profiling and Reverse Genetics Applications

Pierre Hilson
Joke Allemeersch
Thomas Altmann
Sébastien Aubourg
Alexandra Avon
Jim Beynon Rishikesh P. Bhalerao Frédérique Bitton Michel Caboche Bernard Cannoot Vasil Chardakov Cécile Cognet-Holliger Vincent Colot Mark Crowe Caroline Darimont Steffen Durinck Holger Eickhoff Andéol Falcon de Longevialle Edward E. Farmer Murray Grant Martin T.R. Kuiper Hans Lehrach Céline Léon Antonio Leyva Joakim Lundeberg Claire Lurin Yves Moreau Wilfried Nietfeld Javier Paz-Ares Philippe Reymond Pierre Rouzé Goran Sandberg Maria Dolores Segura Carine Serizet Alexandra Tabrett Ludivine Taconnat Vincent Thareau Paul Van Hummelen Steven Vercruysse Marnik Vuylsteke Magdalena Weingartner Peter J. Weisbeek
... [+37 authors] ...,
Valtteri Wirta
Floyd R.A. Wittink
Marc Zabeau
Ian Small

First Published October 15, 2004

LETTER

Transcript Level Alterations Reflect Gene Dosage Effects Across Multiple Tissues in a Mouse Model of Down Syndrome

Pascal Kahlem
Marc Sultan
Ralf Herwig
Matthias Steinfath
Daniela Balzereit
Barbara Eppens Nidhi G. Saran Mathew T. Pletcher Sarah T. South
... [+4 authors] ...,
Gail Stetten
Hans Lehrach
Roger H. Reeves
Marie-Laure Yaspo

First Published July 1, 2004

RESOURCE

Integrated and Sequence-Ordered BAC- and YAC-Based Physical Maps for the Rat Genome

Martin Krzywinski
John Wallis
Claudia Gösele
Ian Bosdet
Readman Chiu
Tina Graves Oliver Hummel Dan Layman Carrie Mathewson Natasja Wye Baoli Zhu Derek Albracht Jennifer Asano Sarah Barber Mabel Brown-John Susanna Chan Steve Chand Alison Cloutier Jonathon Davito Chris Fjell Tony Gaige Detlev Ganten Noreen Girn Kurtis Guggenheimer Heinz Himmelbauer Thomas Kreitler Stephen Leach Darlene Lee Hans Lehrach Michael Mayo Kelly Mead Teika Olson Pawan Pandoh Anna-Liisa Prabhu Heesun Shin Simone Tänzer Jason Thompson Miranda Tsai Jason Walker George Yang Mandeep Sekhon LaDeana Hillier Heike Zimdahl Andre Marziali Kazutoyo Osoegawa Shaying Zhao Asim Siddiqui Pieter J. de Jong Wes Warren Elaine Mardis John D. McPherson Richard Wilson
... [+47 authors] ...,
Norbert Hübner
Steven Jones
Marco Marra
Jacqueline Schein

First Published April 1, 2004

LETTER

The Genomic Sequence and Comparative Analysis of the Rat Major Histocompatibility Complex

Peter Hurt
Lutz Walter
Ralf Sudbrak
Sven Klages
Ines Müller
Takashi Shiina Hidetoshi Inoko
... [+2 authors] ...,
Hans Lehrach
Eberhard Günther
Richard Reinhardt
Heinz Himmelbauer

First Published April 1, 2004

RESOURCE

Generation, Annotation, Evolutionary Analysis, and Database Integration of 20,000 Unique Sea Urchin EST Clusters

Albert J. Poustka
Detlef Groth
Steffen Hennig
Sabine Thamm
Andrew Cameron
Alfred Beck
... [+1 authors] ...,
Richard Reinhardt
Ralf Herwig
Georgia Panopoulou
Hans Lehrach

First Published December 1, 2003

Methods

Clone-Based Systematic Haplotyping (CSH): A Procedure for Physical Haplotyping of Whole Genomes

Carola Burgtorf
Pamela Kepper
Margret Hoehe
Carsten Schmitt
Richard Reinhardt
Hans Lehrach
Sascha Sauer

First Published December 1, 2003

ARTICLE

New Evidence for Genome-Wide Duplications at the Origin of Vertebrates Using an Amphioxus Gene Set and Completed Animal Genomes

Georgia Panopoulou
Steffen Hennig
Detlef Groth
Antje Krause
Albert J. Poustka
Ralf Herwig
Martin Vingron
Hans Lehrach

First Published June 1, 2003

RESOURCE

Advanced Integrated Mouse YAC Map Including BAC Framework

Leonard C. Schalkwyk
Brian Cusack
Ilona Dunkel
Martina Hopp
Markus Kramer
Stefanie Palczewski Jutta Piefke Sabine Scheel
... [+3 authors] ...,
Michael Weiher
Gunther Wenske
Hans Lehrach
Heinz Himmelbauer

First Published December 1, 2001

METHODS

A Human cDNA Expression Library in Yeast Enriched for Open Reading Frames

Caterina Holz
Angelika Lueking
Lara Bovekamp
Claudia Gutjahr
Natalia Bolotina
Hans Lehrach
Dolores J. Cahill

First Published September 20, 2001

RESOURCE

An Oligonucleotide Fingerprint Normalized and Expressed Sequence Tag Characterized Zebrafish cDNA Library

Matthew D. Clark
Steffen Hennig
Ralf Herwig
Sandy W. Clifton
Marco A. Marra
Hans Lehrach
Stephen L. Johnson
the WU-GSC EST Group

First Published August 16, 2001

LETTER

Large-Scale Clustering of cDNA-Fingerprinting Data

Ralf Herwig
Albert J. Poustka
Christine Müller
Christof Bull
Hans Lehrach
John O'Brien

First Published November 1, 1999

RESOURCE

Panel of Microsatellite Markers for Whole-Genome Scans and Radiation Hybrid Mapping and a Mouse Family Tree

Leonard C. Schalkwyk
Martin Jung
Angelika Daser
Michael Weiher
Jörn Walter
Heinz Himmelbauer
Hans Lehrach

First Published September 1, 1999

LETTER

A Contiguous 3-Mb Sequence-Ready Map in the S3–MX Region on 21q22.2 Based on High- Throughput Nonisotopic Library Screenings

Thomas Hildmann
Xianging Kong
John O’Brien
Lisa Riesselman
Hoang-My Christensen
Emilie Dagand
Hans Lehrach
Marie-Laure Yaspo

First Published April 1, 1999

LETTER

Aire Gene: Comparative Genomic Sequencing, Gene Organization, and Expression" > The Mouse Aire Gene: Comparative Genomic Sequencing, Gene Organization, and Expression

Karin Blechschmidt
Michal Schweiger
Karin Wertz
Richard Poulson
Hoang-My Christensen
Andre Rosenthal
Hans Lehrach
Marie-Laure Yaspo

First Published February 1, 1999

RESEARCH

Estimation of Distances and Map Construction Using Radiation Hybrids

William Newell
Stephan Beck
Hans Lehrach
Andrew Lyall

First Published May 1, 1998

LETTER

Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome

Jürgen Groet
Jane H. Ives
Andrew P. South
Pedro R. Baptista
Tania A. Jones
Marie-Laure Yaspo
... [+1 authors] ...,
Hans Lehrach
Marie-Claude Potier
Christine Van Broeckhoven
Dean Nižetić

First Published April 1, 1998

RESEARCH

PEX Gene Mutated in X-Linked Dominant Hypophosphatemic Rickets" > Genomic Organization of the Human PEX Gene Mutated in X-Linked Dominant Hypophosphatemic Rickets

Fiona Francis
Tim M. Strom
Steffen Hennig
Annett Böddrich
Bettina Lorenz
Oliver Brandau Klaus L. Mohnike Michele Cagnoli Christina Steffens Sven Klages Katja Borzym Thomas Pohl Claudine Oudet Michael J. Econs
... [+9 authors] ...,
Peter S.N. Rowe
Richard Reinhardt
Thomas Meitinger
Hans Lehrach

First Published June 1, 1997