Research
RET regulatory code is disrupted in Hirschsprung disease" > A multi-enhancer RET regulatory code is disrupted in Hirschsprung disease
- First Published November 15, 2021
Method
Sequence-based correction of barcode bias in massively parallel reporter assays
- First Published July 20, 2021
Letter
Complex selection on 5′ splice sites in intron-rich organisms
- First Published September 10, 2009
LETTER
Three distinct modes of intron dynamics in the evolution of eukaryotes
- First Published May 10, 2007
LETTER
Evolutionarily conserved genes preferentially accumulate introns
- First Published May 10, 2007
LETTER
Origins and impact of constraints in evolution of gene families
- First Published October 19, 2006
Methods
On the probability that a novel variant is a disease-causing mutation
- First Published June 17, 2005
LETTER
The Human MitoChip: A High-Throughput Sequencing Microarray for Mitochondrial Mutation Detection
- First Published May 3, 2004
LETTER
Coelomata and Not Ecdysozoa: Evidence From Genome-Wide Phylogenetic Analysis
- First Published January 5, 2004
RESOURCE
Development of Human Protein Reference Database as an Initial Platform for Approaching Systems Biology in Humans
- First Published October 2, 2003
LETTER
Gene Loss, Protein Sequence Divergence, Gene Dispensability, Expression Level, and Interactivity Are Correlated in Eukaryotic Evolution
- First Published October 2, 2003
ARTICLE
Linkage Disequilibrium and Haplotype Diversity in the Genes of the Renin–Angiotensin System: Findings From the Family Blood Pressure Program
- First Published January 14, 2003
LETTER
The Role of Lineage-Specific Gene Family Expansion in the Evolution of Eukaryotes
- First Published July 1, 2002
LETTER
Essential Genes Are More Evolutionarily Conserved Than Are Nonessential Genes in Bacteria
- First Published May 16, 2002
RESOURCE
viewGene : A Graphical Tool for Polymorphism Visualization and Characterization" > viewGene : A Graphical Tool for Polymorphism Visualization and Characterization
- First Published February 1, 2002
METHODS
High-Throughput Variation Detection and Genotyping Using Microarrays
- First Published October 15, 2001
COMMENTARY
The Human Genome Sequence Expedition: Views from the “Base Camp”
- First Published May 1, 2001
LETTER
Lineage-Specific Gene Expansions in Bacterial and Archaeal Genomes
- First Published March 13, 2001
ARTICLE
Genome Alignment, Evolution of Prokaryotic Genome Organization, and Prediction of Gene Function Using Genomic Context
- First Published February 8, 2001
LETTER
Prediction of the Archaeal Exosome and Its Connections with the Proteasome and the Translation and Transcription Machineries by a Comparative-Genomic Approach
- First Published February 1, 2001
ARTICLE
Patterns of Meiotic Recombination on the Long Arm of Human Chromosome 21
- First Published September 1, 2000
LETTER
Eukaryote-specific Domains in Translation Initiation Factors: Implications for Translation Regulation and Evolution of the Translation System
- First Published August 1, 2000
LETTER
From Complete Genomes to Measures of Substitution Rate Variability Within and Between Proteins
- First Published July 1, 2000
LETTER
Parallel Genotyping of Human SNPs Using Generic High-density Oligonucleotide Tag Arrays
- First Published June 1, 2000
ARTICLE
The Bacterial Replicative Helicase DnaB Evolved from a RecA Duplication
- First Published January 1, 2000
RESEARCH
Comparative Genomics of the Archaea (Euryarchaeota): Evolution of Conserved Protein Families, the Stable Core, and the Variable Shell
- First Published July 1, 1999
ARTICLE
Distribution of Protein Folds in the Three Superkingdoms of Life
- First Published January 1, 1999
INSIGHT/OUTLOOK
A DNA Polymorphism Discovery Resource for Research on Human Genetic Variation
- First Published December 1, 1998
RESEARCH
Novel Families of Putative Protein Kinases in Bacteria and Archaea: Evolution of the “Eukaryotic” Protein Kinase Superfamily
- First Published October 1, 1998
RESEARCH
Analogous Enzymes: Independent Inventions in Enzyme Evolution
- First Published August 1, 1998
RESEARCH
Allele Frequency Distributions in Pooled DNA Samples: Applications to Mapping Complex Disease Genes
- First Published February 1, 1998
EDITORIAL
The End of the Beginning: The Race to Begin Human Genome Sequencing
- First Published September 1, 1996