Methods
Inference of RhoGAP/GTPase regulation using single-cell morphological data from a combinatorial RNAi screen
- First Published February 9, 2010
Methods
A new strategy for genome assembly using short sequence reads and reduced representation libraries
- First Published February 1, 2010
Methods
Cross-mapping and the identification of editing sites in mature microRNAs in high-throughput sequencing libraries
- First Published January 5, 2010
Methods
Estimating population genetic parameters and comparing model goodness-of-fit using DNA sequences with error
- First Published December 1, 2009
Methods
Targeted chromosomal deletions in human cells using zinc finger nucleases
- First Published December 1, 2009
Methods
Detection of nonneutral substitution rates on mammalian phylogenies
- First Published October 26, 2009
Methods
High-resolution nucleosome mapping reveals transcription-dependent promoter packaging
- First Published October 21, 2009
Methods
Salmonella Typhi gene using one million transposon mutants" > Simultaneous assay of every Salmonella Typhi gene using one million transposon mutants
- First Published October 13, 2009
Methods
Rapid inexpensive genome-wide association using pooled whole blood
- First Published October 3, 2009
Methods
Automatic analysis of dividing cells in live cell movies to detect mitotic delays and correlate phenotypes in time
- First Published October 1, 2009
Methods
Rapid identification of homologous recombinants and determination of gene copy number with reference/query pyrosequencing (RQPS)
- First Published October 1, 2009
Methods
Predictable dynamic program of timing of DNA replication in human cells
- First Published September 18, 2009
Methods
Two-parameter characterization of chromosome-scale recombination rate
- First Published September 14, 2009
Methods
An ensemble model of competitive multi-factor binding of the genome
- First Published August 31, 2009
Methods
Sensitive and accurate detection of copy number variants using read depth of coverage
- First Published August 5, 2009
Methods
Distinguishing direct versus indirect transcription factor–DNA interactions
- First Published August 3, 2009
Methods
Microarray-based multicycle-enrichment of genomic subsets for targeted next-generation sequencing
- First Published July 28, 2009
Methods
Direct multiplex sequencing (DMPS)—a novel method for targeted high-throughput sequencing of ancient and highly degraded DNA
- First Published July 27, 2009
Methods
A probabilistic approach for SNP discovery in high-throughput human resequencing data
- First Published July 15, 2009
Methods
Identification of deleterious mutations within three human genomes
- First Published July 14, 2009
Methods
High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing
- First Published July 6, 2009
Methods
Transcriptional and post-transcriptional profile of human chromosome 21
- First Published July 6, 2009
Methods
Identification of rare cancer driver mutations by network reconstruction
- First Published July 2, 2009
Methods
Sequence and structural variation in a human genome uncovered by short-read, massively parallel ligation sequencing using two-base encoding
- First Published June 22, 2009
Methods
Positional conservation and amino acids shape the correct diagnosis and population frequencies of benign and damaging personal amino acid mutations
- First Published June 22, 2009
Methods
Can the whole be less than the sum of its parts? Pathway analysis in genome-scale metabolic networks using elementary flux patterns
- First Published June 18, 2009
Methods
Next-generation tag sequencing for cancer gene expression profiling
- First Published June 18, 2009
Methods
Profiling the T-cell receptor beta-chain repertoire by massively parallel sequencing
- First Published June 18, 2009
Methods
Genome-wide comparisons of variation in linkage disequilibrium
- First Published June 18, 2009
Methods
Multiplex padlock targeted sequencing reveals human hypermutable CpG variations
- First Published June 12, 2009
Methods
A method for rapid, targeted CNV genotyping identifies rare variants associated with neurocognitive disease
- First Published June 8, 2009
Methods
Genome-wide screen of promoter methylation identifies novel markers in melanoma
- First Published June 2, 2009
Methods
Targeted genome editing in human cells with zinc finger nucleases constructed via modular assembly
- First Published May 21, 2009
Methods
Drosophila melanogaster" > Conserved introns reveal novel transcripts in Drosophila melanogaster
- First Published May 20, 2009
Methods
Incorporating nucleosomes into thermodynamic models of transcription regulation
- First Published May 18, 2009
Methods
DNA Sudoku—harnessing high-throughput sequencing for multiplexed specimen analysis
- First Published May 15, 2009
Methods
Combinatorial algorithms for structural variation detection in high-throughput sequenced genomes
- First Published May 15, 2009
Methods
Shifted Transversal Design smart-pooling for high coverage interactome mapping
- First Published May 15, 2009
Methods
MS-qFRET: A quantum dot-based method for analysis of DNA methylation
- First Published May 14, 2009
Methods
Mapping epigenetic mutations in fission yeast using whole-genome next-generation sequencing
- First Published May 7, 2009
Methods
The difficulty of avoiding false positives in genome scans for natural selection
- First Published May 1, 2009
Methods
Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver
- First Published March 9, 2009