Searching journal content for articles similar to Wang et al. 17 (8): 000.

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  1. Letter: High-throughput sequencing of retrotransposon integration provides a saturated profile of target activity in Schizosaccharomyces pombe
    • Yabin Guo and
    • Henry L. Levin
    Genome Res. February 2010 20: 239-248; Published in Advance December 29, 2009, doi:10.1101/gr.099648.109
    ...Life Sciences (Roche). Cells were induced for the expression of Tf1 containing neo (Tf1-neo), and media containing G418 was used to select for the cells with integration events. As developed for sequencing insertion sites of human immunodeficiency virus 1, (HIV-1) and murine leukemia virus (MLV), we...
  2. Research: A nucleosomal surface defines an integration hotspot for the Saccharomyces cerevisiae Ty1 retrotransposon
    • Joshua A. Baller,
    • Jiquan Gao,
    • Radostina Stamenova,
    • M. Joan Curcio,
    • and Daniel F. Voytas
    Genome Res. April 2012 22: 704-713; Published in Advance January 4, 2012, doi:10.1101/gr.129585.111
    ...of the nucleosome, consistent with favored integrationon the outward-facingDNAsurface, a patternnot observed for Ty1 (Wang et al. 2007; Roth et al. 2011). Like Ty1, however, insertions of HIV and gammaretroviruses were both associated with epigenetic modifications correlated with transcription. Ty1’s preference...
  3. Method: Mobile element scanning (ME-Scan) identifies thousands of novel Alu insertions in diverse human populations
    • David J. Witherspoon,
    • Yuhua Zhang,
    • Jinchuan Xing,
    • W. Scott Watkins,
    • Hongseok Ha,
    • Mark A. Batzer,
    • and Lynn B. Jorde
    Genome Res. July 2013 23: 1170-1181; Published in Advance April 18, 2013, doi:10.1101/gr.148973.112
    ...retrotransposition rates and site preferences in vivo, prior to the action of confounding forces such as natural selection, demographic changes, and post-integration rearrangements. The singleton Alu insertion we identified here in the first coding exon of FAM187B exemplifies this potential (Supplemental Fig. S6...
  4. LETTER: Chromodomains direct integration of retrotransposons to heterochromatin
    • Xiang Gao,
    • Yi Hou,
    • Hirotaka Ebina,
    • Henry L. Levin,
    • and Daniel F. Voytas
    Genome Res. March 2008 18: 359-369; Published in Advance February 6, 2008, doi:10.1101/gr.7146408
    ...for promoter regions ( Wu et al. 2003 ), and human immunodeficiency virus (HIV) integrates preferentially into actively transcribed genes at sites with transcription-associated histone modifications ( Schroder et al. 2002 ; Wang et al. 2007 ). In contrast to targeting to specific transcription complexes...
  5. Research: Retrotransposon Ty1 integration targets specifically positioned asymmetric nucleosomal DNA segments in tRNA hotspots
    • Loris Mularoni,
    • Yulian Zhou,
    • Tyson Bowen,
    • Sunil Gangadharan,
    • Sarah J. Wheelan,
    • and Jef D. Boeke
    Genome Res. April 2012 22: 693-703; Published in Advance January 4, 2012, doi:10.1101/gr.129460.111
    ...on gammaretrovirus MLV as well as HIV show that these viruses also preferentially insert into nucleosomal DNA. However, the patterns of retroviral insertions into nucleosomes is distinct from that of Ty1, hitting a wide variety of outward-facing major groove nucleosomal DNA sites distributed throughout...
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