Searching journal content for articles similar to Chen et al. 26 (10): 1355.

Displaying results 1-9 of 9
For checked items
  1. Method: An extended set of yeast-based functional assays accurately identifies human disease mutations
    • Song Sun,
    • Fan Yang,
    • Guihong Tan,
    • Michael Costanzo,
    • Rose Oughtred,
    • Jodi Hirschman,
    • Chandra L. Theesfeld,
    • Pritpal Bansal,
    • Nidhi Sahni,
    • Song Yi,
    • Analyn Yu,
    • Tanya Tyagi,
    • Cathy Tie,
    • David E. Hill,
    • Marc Vidal,
    • Brenda J. Andrews,
    • Charles Boone,
    • Kara Dolinski,
    • and Frederick P. Roth
    Genome Res. May 2016 26: 670-680; Published in Advance March 14, 2016, doi:10.1101/gr.192526.115
    .... Of the 78 alleles we tested that are not known to be associated with disease, 68 (87%) were neutral according to functional assays. As a pathogenicity assay, functional complementation outperformed all computational methods examined. Functional assays have the potential to provide insight into disease...
    OPEN ACCESS ARTICLE
  2. Research: Unique genetic basis of the distinct antibiotic potency of high acetic acid production in the probiotic yeast Saccharomyces cerevisiae var. boulardii
    • Benjamin Offei,
    • Paul Vandecruys,
    • Stijn De Graeve,
    • María R. Foulquié-Moreno,
    • and Johan M. Thevelein
    Genome Res. September 2019 29: 1478-1494; Published in Advance August 29, 2019, doi:10.1101/gr.243147.118
    ...in the treatment of multiple gastrointestinal disorders (Guandalini 2008, 2011; McFarland 2009). This is also true for the yeast S. boulardii (McFarland 2010; Girardin and Seidman 2011; Currò et al. 2017). It is the only yeast strain that is prescribed as a probiotic against gastrointestinal diseases...
    OPEN ACCESS ARTICLE
  3. Method: Nanopore sequencing of complex genomic rearrangements in yeast reveals mechanisms of repeat-mediated double-strand break repair
    • Ryan J. McGinty,
    • Rachel G. Rubinstein,
    • Alexander J. Neil,
    • Margaret Dominska,
    • Denis Kiktev,
    • Thomas D. Petes,
    • and Sergei M. Mirkin
    Genome Res. December 2017 27: 2072-2082; Published in Advance November 7, 2017, doi:10.1101/gr.228148.117
    ...that Nanopore sequencing is an effective and efficient method of identifying novel CGRs in S. cerevisiae, which provided important insights into the mechanisms of DNA repair.ResultsInitial characterization of CGRsTo generate strains with CGRs, we used a previously characterized selectable system for repeat...
    OPEN ACCESS ARTICLE
  4. Research: Yeast genetic interaction screen of human genes associated with amyotrophic lateral sclerosis: identification of MAP2K5 kinase as a potential drug target
    • Myungjin Jo,
    • Ah Young Chung,
    • Nozomu Yachie,
    • Minchul Seo,
    • Hyejin Jeon,
    • Youngpyo Nam,
    • Yeojin Seo,
    • Eunmi Kim,
    • Quan Zhong,
    • Marc Vidal,
    • Hae Chul Park,
    • Frederick P. Roth,
    • and Kyoungho Suk
    Genome Res. September 2017 27: 1487-1500; Published in Advance June 8, 2017, doi:10.1101/gr.211649.116
    ...). This network also revealed the relationships among the 20 OMIM genes. IPA-based protein–protein interactions were also included in the network. Thus, a -wide human–yeast genetic interaction screen followed by a search for human orthologs provided a “first draft” disease-gene interaction network for a subset...
    OPEN ACCESS ARTICLE
  5. ARTICLE: Retroviruses and yeast retrotransposons use overlapping sets of host genes
    • Becky Irwin,
    • Michael Aye,
    • Pierre Baldi,
    • Nadejda Beliakova-Bethell,
    • Henry Cheng,
    • Yimeng Dou,
    • Willy Liou,
    • and Suzanne Sandmeyer
    Genome Res. May 2005 15: 641-654; Published in Advance April 18, 2005, doi:10.1101/gr.3739005
    ...Retroviruses and yeast retrotransposons use overlapping sets of host genes Becky Irwin 1 , 4 , Michael Aye 1 , 3 , 4 , Pierre Baldi 1 , 2 , 3 , Nadejda Beliakova-Bethell 1 , Henry Cheng 1 , Yimeng Dou 2 , 3 , Willy...
    OPEN ACCESS ARTICLE
  6. Resource: Phenotypic diversity and genotypic flexibility of Burkholderia cenocepacia during long-term chronic infection of cystic fibrosis lungs
    • Amy Huei-Yi Lee,
    • Stephane Flibotte,
    • Sunita Sinha,
    • Adrianna Paiero,
    • Rachel L. Ehrlich,
    • Sergey Balashov,
    • Garth D. Ehrlich,
    • James E.A. Zlosnik,
    • Joshua Chang Mell,
    • and Corey Nislow
    Genome Res. April 2017 27: 650-662; Published in Advance March 21, 2017, doi:10.1101/gr.213363.116
    ...bacterial evolution during chronic infections can provide insights into how host selection pressures—including immune responses and therapeutic interventions—shape bacterial s. We carried out genomic and phenotypic analyses of 215 serially collected Burkholderia cenocepacia isolates from 16 cystic fibrosis...
    OPEN ACCESS ARTICLE
  7. Method: A novel assay to screen siRNA libraries identifies protein kinases required for chromosome transmission
    • Mikhail Liskovykh,
    • Nikolay V. Goncharov,
    • Nikolai Petrov,
    • Vasilisa Aksenova,
    • Gianluca Pegoraro,
    • Laurent L. Ozbun,
    • William C. Reinhold,
    • Sudhir Varma,
    • Mary Dasso,
    • Vadim Kumeiko,
    • Hiroshi Masumoto,
    • William C. Earnshaw,
    • Vladimir Larionov,
    • and Natalay Kouprina
    Genome Res. October 2019 29: 1719-1732; Published in Advance September 12, 2019, doi:10.1101/gr.254276.119
    ...attributable to the development of conceptually simple color colony assays in yeast that provided a powerful high-throughput genetic tool to assess the rates of chromosome mis-segregation and to identify mutants deficient in this process (Spencer et al. 1990). The final list of yeast genes involved...
    OPEN ACCESS ARTICLE
  8. Resource: Genes essential for embryonic stem cells are associated with neurodevelopmental disorders
    • Shahar Shohat and
    • Sagiv Shifman
    Genome Res. November 2019 29: 1910-1918; Published in Advance October 24, 2019, doi:10.1101/gr.250019.119
    ..., and that the human phenotypes most significantly associated with genes essential for ESCs are neurodevelopmental. Our results provide insights into essential genes in the mouse, the pathways which govern pluripotency, and suggest that many genes associated with neurodevelopmental disorders are essential at very...
  9. Resource: A fine scale phenotype–genotype virulence map of a bacterial pathogen
    • Tim van Opijnen and
    • Andrew Camilli
    Genome Res. December 2012 22: 2541-2551; Published in Advance July 23, 2012, doi:10.1101/gr.137430.112
    ...defined in vitro stress conditions with in vivo colonization and disease states. Besides creating a resource that provides insight into the biology and virulence of this pathogen,we have drawnup a detailed roadmap that can be used to navigate similar discovery in othermicroorganisms. Results...
For checked items

Search Results

New Search

Modify Results

Citation format:
Results / page:
Results order:

This search

  • Alert me when new articles matching this search are published
  • Download all citations on this page to my citation manager

Preprint Server



Current Issue

  1. March 2026, 36 (3)
  1. Current Issue
  1. Alert me to new issues of Genome Research