Table of Contents

Preface

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20 Years of Genome Research
Genome Res. October 2015 25: xv; doi:10.1101/gr.199026.115

Research

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Signatures of post-zygotic structural genetic aberrations in the cells of histologically normal breast tissue that can predispose to sporadic breast cancer
- Lars A. Forsberg,
- Chiara Rasi,
- Gyula Pekar,
- Hanna Davies,
- Arkadiusz Piotrowski,
- Devin Absher,
- Hamid Reza Razzaghian,
- Aleksandra Ambicka,
- Krzysztof Halaszka,
- Marcin Przewoźnik,
- Anna Kruczak,
- Geeta Mandava,
- Saichand Pasupulati,
- Julia Hacker,
- K. Reddy Prakash,
- Ravi Chandra Dasari,
- Joey Lau,
- Nelly Penagos-Tafurt,
- Helena M. Olofsson,
- Gunilla Hallberg,
- Piotr Skotnicki,
- Jerzy Mituś,
- Jaroslaw Skokowski,
- Michal Jankowski,
- Ewa Śrutek,
- Wojciech Zegarski,
- Eva Tiensuu Janson,
- Janusz Ryś,
- Tibor Tot,
- and Jan P. Dumanski
Genome Res. October 2015 25: 1521-1535; doi:10.1101/gr.187823.114
OPEN ACCESS ARTICLE
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Widespread somatic L1 retrotransposition occurs early during gastrointestinal cancer evolution
- Adam D. Ewing,
- Anthony Gacita,
- Laura D. Wood,
- Florence Ma,
- Dongmei Xing,
- Min-Sik Kim,
- Srikanth S. Manda,
- Gabriela Abril,
- Gavin Pereira,
- Alvin Makohon-Moore,
- Leendert H.J. Looijenga,
- Ad J.M. Gillis,
- Ralph H. Hruban,
- Robert A. Anders,
- Katharine E. Romans,
- Akhilesh Pandey,
- Christine A. Iacobuzio-Donahue,
- Bert Vogelstein,
- Kenneth W. Kinzler,
- Haig H. Kazazian, Jr.,
- and Szilvia Solyom
Genome Res. October 2015 25: 1536-1545; Published in Advance August 10, 2015, doi:10.1101/gr.196238.115
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The frequent evolutionary birth and death of functional promoters in mouse and human
- Robert S. Young,
- Yoshihide Hayashizaki,
- Robin Andersson,
- Albin Sandelin,
- Hideya Kawaji,
- Masayoshi Itoh,
- Timo Lassmann,
- Piero Carninci,
- The FANTOM Consortium,
- Wendy A. Bickmore,
- Alistair R. Forrest,
- and Martin S. Taylor
Genome Res. October 2015 25: 1546-1557; Published in Advance July 30, 2015, doi:10.1101/gr.190546.115
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Genetic and environmental control of host-gut microbiota interactions
- Elin Org,
- Brian W. Parks,
- Jong Wha J. Joo,
- Benjamin Emert,
- William Schwartzman,
- Eun Yong Kang,
- Margarete Mehrabian,
- Calvin Pan,
- Rob Knight,
- Robert Gunsalus,
- Thomas A. Drake,
- Eleazar Eskin,
- and Aldons J. Lusis
Genome Res. October 2015 25: 1558-1569; Published in Advance August 10, 2015, doi:10.1101/gr.194118.115
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Methods

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Read clouds uncover variation in complex regions of the human genome
- Alex Bishara,
- Yuling Liu,
- Ziming Weng,
- Dorna Kashef-Haghighi,
- Daniel E. Newburger,
- Robert West,
- Arend Sidow,
- and Serafim Batzoglou
Genome Res. October 2015 25: 1570-1580; Published in Advance August 18, 2015, doi:10.1101/gr.191189.115
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CETCh-seq: CRISPR epitope tagging ChIP-seq of DNA-binding proteins
- Daniel Savic,
- E. Christopher Partridge,
- Kimberly M. Newberry,
- Sophia B. Smith,
- Sarah K. Meadows,
- Brian S. Roberts,
- Mark Mackiewicz,
- Eric M. Mendenhall,
- and Richard M. Myers
Genome Res. October 2015 25: 1581-1589; Published in Advance September 9, 2015, doi:10.1101/gr.193540.115

Preface

20 Years of Genome Research

Perspectives

A vision for ubiquitous sequencing

Biological data sciences in genome research

Parlez-vous VUS?

Functional genomics bridges the gap between quantitative genetics and molecular biology

Genomic approaches for understanding the genetics of complex disease

Enabling functional genomics with genome engineering

Linking RNA biology to lncRNAs

Half dozen of one, six billion of the other: What can small- and large-scale molecular systems biology learn from one another?

The Mendelian disorders of the epigenetic machinery

Epigenomics and the structure of the living genome

Defining cell types and states with single-cell genomics

The first five years of single-cell cancer genomics and beyond

The path to routine use of genomic biomarkers in the cancer clinic

The intersection of microbiome and host at the skin interface: genomic- and metagenomic-based insights

Research

Signatures of post-zygotic structural genetic aberrations in the cells of histologically normal breast tissue that can predispose to sporadic breast cancer

Widespread somatic L1 retrotransposition occurs early during gastrointestinal cancer evolution

The frequent evolutionary birth and death of functional promoters in mouse and human

Genetic and environmental control of host-gut microbiota interactions

Methods

Read clouds uncover variation in complex regions of the human genome

CETCh-seq: CRISPR epitope tagging ChIP-seq of DNA-binding proteins

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