A Gene Map of the Best’s Vitelliform Macular Dystrophy Region in Chromosome 11q12–q13.1

Contig

No. of clones identified

Clone(s)

analyzed

Size^a

(bp)

GenBank Acc. No.

dbEST search

(Accession No. of best match)

Genetic interval^b

Repeats

Northern Blot Analysis

Transcription unit

C96-5

1

IIIG8

413

AF009747

C96-5 = N36152

S1357-S1765

-

+

TU2

C96-9

1

IIIE6

~ 2000

AF009748/9

C96-9r bp 1-363 = N25572

-

-

+

TU3

C96-7

1

IIIB8

~ 900

AF009750/1

C96-7f bp 47-155 = N77316 bp 48-156

S1357-S913

Alu

+

TU4

C96-8

1

IIIE2

~ 700

AF009752/3

C96-8f bp 16-219 = R02752 bp 1-203

S1357-S1765

-

+

TU6

C97A-1

8

IVF8/VF10

921

AF009754

C97A-1 bp 1-324 = H28152 bp 880-554

C97A-1 bp 325-518 = N46745 bp 94-287

C97A-1 bp 504-921 = R37277 bp 448-22

S1357-S1765

-

+

TU10

C97A-5

C97A-7

C97A-18

6

4

4

IVB7/IVE11

IVC4

VD3

479

410

~ 800

AF009755

AF009756

AF009757/8

C97A-5 = AA160602

C97A-7 = AA112061

C97A-18f bp 1-272 = AA084193 bp 336-65

C97A-18r bp 1-216 = R12156 bp 236-442

S1357-S1765

S1357-S1765

S1357-S1765

Alu

-

-

+

+

+

TU12

C97A-8

1

IVB8

401

AF009759

C97A-8 = H17114

S1357-S913

-

+

TU13

C97B-3

1

IXF9

405

AF009760

C97B-3 bp 180-405 = W86214 bp 1-225

C97B-3 bp 17-154 = W84695 bp 5-141

-

-

+

TU15

C97B-9

5

IXH3

337

AF009761

C97B-9 bp 43-325 = N58427 bp 285-1

-

-

+

TU16

C97A-4

1

IVA9

577

AF009762

C97A-4 bp 328-553 = R11137 bp 229-1

-

-

no signal

C97A-10

13

VID3

~ 800

AF009763/4

C97A-10f bp 1-108 = AA226381

-

Alu

no signal

C97A-11

1

IVH4

~ 700

AF009765/6

C97A-11f bp 32-102 = R94966 bp 200-130

-

Alu

no signal

C97A-12

17

VIF10

635

AF009767

C97A-12 bp 374-635= AA430733 bp 403-142

C97A-12 bp 19-273 = T51930 bp 1-255

-

Alu

no signal

C97A-13

1

IVG7

301

AF009768

C97A-13 = H49262

-

Alu

no signal

C97B-11

7

IXA6

600

AF009769

no similarity

-

-

+

TU17

C96-4

1

IA1

300

AF009770

no similarity

-

-

no signal

C96-6

3

ID5/IID6

IIIE5

664

AF009771

no similarity

-

Alu

no signal

C97A-2

C97A-19

8

7

IVC2/VIA6

VA5

746

363

AF009772

AF009773

no similarity

no similarity

-

-

-

Alu

no signal

C97A-15

1

VB5

~ 850

AF009774/5

no similarity

-

Alu

no signal

C97A-16

2

VC12

352

AF009776

no similarity

-

Alu

no signal

C97A-20

1

VF5

411

AF009777

no similarity

-

-

no signal

C97B-2

3

IXF5

~ 700

AF009778/9

no similarity

-

L1, Alu

no signal

C97B-4

5

IXA5

502

AF009784

no similarity

-

LTR3

no signal

C97B-7

3

IXF2

219

AF009780

no similarity

-

-

no signal

C97B-8

1

IXA9

~ 800

AF009781/2

no similarity

-

Alu

no signal

C97B-12

3

IXF4

339

AF009783

no similarity

-

-

no signal