Table 4.
Mammalian Genes with Two Apparent Zebrafish Orthologs
| Mammalian gene | Zebrafish Co-orthologs | |
| BMP2 | BMP2A (U82233) | BMP2B (AF072456) |
| DLL1 | DELTAA (AF030031) | DELTAD (Y11760) |
| DLX2 | DLX5 (U67843) | DLX2 (U03875) |
| EN2 | ENG3(X68447) | ENG2 (X68446) |
| FKD5 | FKD5(AF052248) | FKD3 (AF052246) |
| GDF6 | RADAR(914116) | DYNAMO (X99769) |
| Hes5 (mouse) | HER2(X97330) | HER4 (X97332) |
| Islet2 (rat) | ISLET2(X88805) | ISLET3 (D38454) |
| L1CAM | NADL1.1(X89204) | NADL1.2 (X89205) |
| LHX1 | LIM6(AF001299) | LIM1 (L37802) |
| Msx3 (mouse) | MSXB(U16311) | MSXC (X65061) |
| Ntn1 (mouse) | NETRIN1A(AF002717) | NETRIN1 (AF017420) |
| OTX1 | OTX3(D26174) | OTX1 (U14591) |
| PAX2 | PAX2.1(X63961) | PAX2.2 (AF072547) |
| RARA | RARA2B(L03399) | RARA2A (L03398) |
| SHH | TWHH(U30710) | SHH (Z35669) |
| SNA | SNA1(S68799) | SNA2 (U24225) |
| SNAP25 | SNAP25B(AF091594) | SNAP25A (AF091593) |
-
Phylogenetic analysis identified 18 mammalian genes that clustered with pairs of zebrafish genes (see example in Fig. 3B). In all of these cases, this clustering was supported by a bootstrap value of at least 800 of 1000. Other mammalian genes with two possible zebrafish orthologs whose bootstrap values were <800 of 1000 were identified but not listed here. The mammalian genes shown are from human unless otherwise noted. GenBank accession nos. are in parentheses.
