The Relative Power of Family-Based and Case-Control Designs for Linkage Disequilibrium Studies of Complex Human Diseases. II. Individual Genotyping

Table 3.

Number of Sibships Without Parents Required to Detect LD Using Individual Genotyping

r = 1 r = 2 r = 3 r = 4
s = 1 s = 2 s = 1 s = 2 s = 2 s = 2
Dominant
 P = 0.05 642 430 196 137 72 52
 P= 0.20 455 312 250 173 147 155
 P = 0.70 5,659 4,254 6,890 4,510 6,414 9,546
Recessive
 P = 0.05 79,709 61,544 18,376 13,202 3,358 965
 P= 0.20 2,097 1,528 582 410 152 76
 P = 0.70 443 297 254 178 152 160
Multiplic
 P= 0.05 2,538 1,715 946 642 314 180
 P = 0.20 870 604 421 286 177 125
 P = 0.70 938 649 595 404 311 269
Additive
 P= 0.05 1,490 1,002 520 356 177 110
 P = 0.20 688 475 359 244 173 142
 P = 0.70 1,393 980 959 647 505 42

  • (r) Number of affected sibs; (s) Number of unaffected sibs.

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  1. Genome Res. 9: 234-241

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