The Relative Power of Family-Based and Case-Control Designs for Linkage Disequilibrium Studies of Complex Human Diseases. II. Individual Genotyping

Table 2.

Probabilities of Different Outcomes for r Affected ands Unaffected Sibs and Scores for the TDSStatistic

Group Outcome Score Probability
1 2 1 2
I (r,0,0,s,0,0) +1 +1 0 m (r) 22 + 2s m (r) (21) c r 21 + 4s m 11 (r) c r 12
II (0,0,r,0,0,s) 0 0 0 4−s m 11 (r) c 10 r + 2s m (10) (r) c 00 r +m 00 (r)
III (0,r,0,0,s,0) 1/2 1/2 0 2s m (21) (r) c (20) r +m (20) (r)+ 2s m 11 (r) c 11 r + 2s m (10) (r) c 01 r
IV (j 2,j 1,0,k 2,k 1,0) (j 2 + ½j 1) /r 3/4 (j 2j 1) / 4r (j2 r)(k2 s)2s[m (21) (r) c 21 j2 c 20 j1+ 2k2 m 11 (r) c 12 j2 c 11 j1]
V (0,j 1,j 0,0,k 1,k 0) j 1 / 2r 1/4 (j 1j 0) / 4r (j0 r)(k0 s)2s[m (10) (r) c 01 j1 c 00 j0 + 2k0 m 11 (r) c 11 j1 c 10 j0]
VI (j 2,j 1,j 0,k 2,k 1,k 0) (j 2+ ½j 1) /r 1/2 (j 2j 0) / 2r (r j2 ,j1 ,j0)(s k2 ,k1 ,k0)2k1 − 2t m 11 (r) c 12 j2 c 11 j1 c 10 j0

This Article

  1. Genome Res. 9: 234-241

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