The Relative Power of Family-Based and Case-Control Designs for Linkage Disequilibrium Studies of Complex Human Diseases. II. Individual Genotyping

Table 1.

Genotype Outcomes, Scores, and Probabilities for Affected–Unaffected Sib Pair

Affected sib Unaffected sib Sample
frequency score ( S) probability
AA AA n 22 0 m 22+ m (21) f 2 / 2(f 2 + f 1) +m 11 f 2 / 4(f 2 + 2f 1 + 1)
AA Aa n 21 1/4 m (21) f 2/ 2(f 2 + f 1) +m 11 f 2 / 2(f 2 + 2f 1 + 1)
AA aa n 20 1/2 m 11 f 2/ 4(f 2 + 2f 1 + 1)
Aa AA n 12 −1/4 m (21) f 1/ 2(f 2 + f 1) +m 11 f 1 / 2(f 2 + 2f 1 + 1)
Aa Aa n 11 0 m (21) f 1/ 2(f 2 + f 1) +m (20) + m 11 f 1/ 2(f 2 + 2f 1 + 1) +m (10) f 1 / 2(f 1 + 1)
Aa aa n 10 1/4 m (10) f 1/ 2(f 1 + 1) +m 11 f 1 / (f 2 + 2f 1 + 1)
aa AA n 02 −1/2 m 11/ 4(f 2 + 2f 1 + 1)
aa Aa n 01 −1/4 m (10)/ 2(f 1 + 1) + m 11 / 2(f 2 + 2f 1 + 1)
aa aa n 00 0 m (10)/ 2(f 1 + 1) + m 11 / 4(f 2 + 2f 1 + 1) +m 00

This Article

  1. Genome Res. 9: 234-241

Preprint Server



Current Issue

  1. January 2026, 36 (1)
  1. Current Issue
  1. Alert me to new issues of Genome Research