Evolution of sequence analysis with the progression of prefinished sequence data. During the sequencing of genomic clones, prefinished sequence contigs eventually merge together. The approach described here allows the retention of information derived from the earlier analysis of the smaller sequence contigs. (A) Two small prefinished sequence contigs and their associated annotated feature are shown relative to their eventual positions within the finished sequence. During the subsequent analysis of the finished sequence (or even the sequence obtained by the merger of the two small contigs), all of the features deduced at an earlier stage can be directly incorporated into an updated Sequin record. (B) A more detailed view of a portion of the final sequence is shown, which reveals the presence of sequence features annotated at an earlier stage of analysis (e.g., CpG islands, CDK6 CDS).
