Figure 6.
Expression of Aire at 14.5 dpc is restricted to few cells in the thymus. RNA in situ hybridization with Aire antisense riboprobe recognizing exons 1–7. No signal was detected upon hybridization with a sense probe.
(A) Sagittal section through 14.5 dpc. mouse embryo, counterstained with eosin. (B) Transverse section of thymic lobes of a 14.5 dpc. embryo. (C) Sagittal section of 14.5 dpc. thymus, counterstained with eosin. (D) Sagittal section of 14.5 dpc. thymus, counterstained with hematoxylin and eosin, at higher magnification.
Arrows point to single cells or cell groups expressing Aire.
