CAGGG Repeats and the Pericentromeric Duplication of the Hominoid Genome

Table 2.

Pairwise Sequence Comparisons of Duplicated Sequences

Query Accession no. Locus Target Accession no. Locus Duplicon L m INDEL K D(Mya)
AC004527 21q11 AC004222 17q11 NF1-A 11184 638 110 5.70 ± 0.24 13.0
AC002041 16p11 HSU36341 Xq28 CTR-CDM 26109 1119 82 4.43 ± 0.13 10.1
D87003/018 22q11 AL022345 10q11 KIAA0187 16372 657 59 4.14 ± 0.16 9.4
AC004527 21q11 AC000382 11 chro11 2891 199 36 7.23 ± 0.52 16.4
AC002041 16p11 L26963 14q32.3 VH 506 24 0 4.93 ± 1.02 11.1
D87003/018 22q11 AC004526 17q11 NF1-B 968 98 7 10.92 ± 1.13 24.8
AC002042 16p11 AC004526 17q11 NF1-C 976 99 6 10.94 ± 1.13 24.8

  • The chromosomal location of both the target and query sequences are shown. Sequences were aligned using GAP optimal global alignment software. Alignments were analyzed using locally developed software (alignscorer) to determine the number of nucleotide sites compared (L), number of sequence mismatches (m) and the number of insertion/deletions (INDEL). The number of substitutions per nucleotide site and standard error were calculated using Kimura's-two step method (Kimura 1980). An evolutionary rate of nucleotide substitution for pseudogene sequences (2.2 × 10−9 substitutions per site per year) was used to approximate the evolutionary age of each duplication.

This Article

  1. Genome Res. 9: 1048-1058

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